Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury

• Published in: Critical care and resuscitation Vol. 17; no. 2; pp. 92 - 100
• Main Authors: Nichol, Alistair, Gantner, Dashiell, Presneill, Jeffrey, Murray, Lynnette, Trapani, Tony, Bernard, Stephen, Cameron, Peter, Capellier, Gilles, Forbes, Andrew, McArthur, Colin, Newby, Lynette, Rashford, Stephen, Rosenfeld, Jeffrey V, Smith, Tony, Stephenson, Michael, Varma, Dinesh, Walker, Tony, Webb, Steve, Cooper, D James
• Format: Journal Article
• Language: English
• Published: Australia 01.06.2015
• Subjects: Adult; Brain Injuries - therapy; Cold; Critical Care; Emergency Medical Services; Humans; Hypothermia; Hypothermia, Induced - methods; Intracranial pressure; Medical care, Cost of; Mortality; Multicenter Studies as Topic; Outcome Assessment (Health Care); Physiological effect; Research Design; Traumatology; United States

Introduction: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Prophylactic hypothermia is effective in laboratory models, but clinical studies to date have been inconclusive, partly because of methodological limitations. Our Prophylactic Hypothermia Trial to Lessen...