[99mTc]Tc-PSMA-T4—Novel SPECT Tracer for Metastatic PCa: From Bench to Clinic

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 21; p. 7216
• Main Authors: Maurin, Michał, Wyczółkowska, Monika, Sawicka, Agnieszka, Sikora, Arkadiusz Eugeniusz, Karczmarczyk, Urszula, Janota, Barbara, Radzik, Marcin, Kłudkiewicz, Dominik, Pijarowska-Kruszyna, Justyna, Jaroń, Antoni, Wojdowska, Wioletta, Garnuszek, Piotr
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2022; MDPI
• Subjects: Antigens; Biodistribution; Biopsy; Chromatography; Disease; in vitro; in vivo; kit formulation development; Ligands; Mass spectrometry; Metastasis; NMR; Nuclear magnetic resonance; Nuclear medicine; Pharmacokinetics; preclinical study; Prostate cancer; PSMA-HYNIC ligands; PSMA-T4; Retention; Scientific imaging; Tomography

Despite significant advances in nuclear medicine for diagnosing and treating prostate cancer (PCa), research into new ligands with increasingly better biological properties is still ongoing. Prostate-specific membrane antigen (PSMA) ligands show great potential as radioisotope carriers for the diagn...