Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination

• Published in: Blood Vol. 117; no. 25; pp. 6813 - 6824
• Main Authors: Pospori, Constandina, Xue, Shao-An, Holler, Angelika, Voisine, Cecile, Perro, Mario, King, Judith, Fallah-Arani, Farnaz, Flutter, Barry, Chakraverty, Ronjon, Stauss, Hans J., Morris, Emma C.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 23.06.2011; Americain Society of Hematology
• Subjects: Animals; Biological and medical sciences; Cell Line; Gene Expression; Gene Transfer Techniques; Hematologic and hematopoietic diseases; Humans; Immunologic Memory; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Stem Cells - immunology; Stem Cells - metabolism; T-Lymphocytes - cytology; T-Lymphocytes - immunology; Thymus Gland - immunology; Vaccination; Wilms Tumor - immunology; WT1 Proteins - genetics; WT1 Proteins - immunology; Prevention; Specificity; Tumor associated antigen; Hematology; Vaccination; T-Lymphocyte; Wilms tumor gene; Tumor suppressor gene; Memory lymphocyte

Recently, vaccines against the Wilms Tumor antigen 1 (WT1) have been tested in cancer patients. However, it is currently not known whether physiologic levels of WT1 expression in stem and progenitor cells of normal tissue result in the deletion or tolerance induction of WT1-specific T cells. Here, w...