Glucuronidation of 7-Ethyl-10-hydroxycamptothecin (SN-38) by the Human UDP-Glucuronosyltransferases Encoded at the UGT1 Locus

• Published in: Biochemical and biophysical research communications Vol. 260; no. 1; pp. 199 - 202
• Main Authors: Ciotti, Marco, Basu, Nikhil, Brangi, Mariafiorella, Owens, Ida S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.06.1999
• Subjects: Animals; Camptothecin - analogs & derivatives; Camptothecin - metabolism; COS Cells; Glucuronidase - metabolism; Glucuronosyltransferase - metabolism; Humans; Hydrogen-Ion Concentration; Kinetics; Monosaccharide Transport Proteins - metabolism

7-Ethyl-10-hydroxycamptothecin (SN-38) is a very promising anticancer drug used for the treatment of metastatic colonrectal cancer. SN-38 is the active metabolite of irinotecan, a semisynthetic anticancer drug derived from 20(S)camptothecin. In this study, we examined the potential for each of the U...