Reactive oxygen species-independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 7; pp. 3030 - 3033
• Main Authors: van de Veerdonk, Frank L, Smeekens, Sanne P, Joosten, Leo A.B, Kullberg, Bart Jan, Dinarello, Charles A, van der Meer, Jos W.M, Netea, Mihai G
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences 16.02.2010; National Acad Sciences
• Subjects: Biological Sciences; caspase-1; Chronic granulomatous disease; Crystals; Cytokines; Familial Mediterranean fever; gene expression; humans; in vitro studies; Inflammation; inflammatory bowel disease; interleukin-18; interleukin-1beta; mice; Monocytes; mutation; NADP (coenzyme); oxygen; patients; phenotype; Reactive oxygen species; Secretion; Uric acid; Volunteerism; Western blotting

Humans with chronic granulomatous diseases (CGDs) due to mutations in p47-phox have defective NADPH activity and thus cannot generate NADPH-dependent reactive oxygen species (ROS). The role of ROS in inflammation is controversial; some in vitro studies suggest that ROS are crucial for secretion of I...