Reactive oxygen species-independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease - van de Veerdonk, Frank L; Smeekens, Sanne P; Joosten, Leo A.B; Kullberg, Bart Jan; Dinarello, Charles A; van der Meer, Jos W.M; Netea, Mihai G (Proceedings of the National Academy of Sciences - PNAS, 2010)
Keywords: Biological Sciences; caspase-1; Chronic granulomatous disease; Crystals; Cytokines; Familial Mediterranean fever; gene expression; humans; in vitro studies; Inflammation; inflammatory bowel disease; interleukin-18; interleukin-1beta; mice; Monocytes; mutation; NADP (coenzyme); oxygen; patients; phenotype; Reactive oxygen species; Secretion; Uric acid; Volunteerism; Western blotting