Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

• Published in: Immunity (Cambridge, Mass.) Vol. 25; no. 3; pp. 455 - 471
• Main Authors: Li, Ming O., Sanjabi, Shomyseh, Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2006
• Subjects: Animals; Cell Differentiation - genetics; Cell Differentiation - immunology; CELLIMMUNO; Cells, Cultured; DEVBIO; Homeostasis - genetics; Homeostasis - immunology; Immune Tolerance - genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Signal Transduction - genetics; Signal Transduction - immunology; T-Lymphocytes - cytology; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes, Regulatory - immunology; Transforming Growth Factor beta - deficiency; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - physiology; DEVBIO; CELLIMMUNO

The role of transforming growth factor-β (TGF-β) in inhibiting T cell functions has been studied with dominant-negative TGF-β receptor transgenic models; however, the full impact of TGF-β signaling on T cells and the mechanisms by which TGF-β signals remain poorly understood. Here we show that mice...