Tissue Factor Pathway and the Antiphospholipid Syndrome

• Published in: Journal of autoimmunity Vol. 15; no. 2; pp. 217 - 220
• Main Author: Roubey, Robert A.S
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2000
• Subjects: antiphospholipid syndrome; Antiphospholipid Syndrome - blood; b2-glycoprotein I; Humans; Thromboplastin - metabolism; Thromboplastin - physiology; Thrombosis - blood; tissue factor; tissue factor, tissue factor pathway inhibitor, monocytes, endothelial cells; tissue factor, tissue factor pathway inhibitor, monocytes, endothelial cells

Expression of tissue factor activity on cells in contact with flowing blood is the trigger for physiological coagulation as well as many types of thrombosis. A number of older observations and considerable recent data suggest that increased tissue factor activity is an important cause of hypercoagul...