Key Regulators of Angiogenesis and Inflammation Are Dysregulated in Patients with Varicose Veins

• Published in: International journal of molecular sciences Vol. 25; no. 12; p. 6785
• Main Authors: Zalewski, Daniel, Chmiel, Paulina, Kołodziej, Przemysław, Kocki, Marcin, Feldo, Marcin, Kocki, Janusz, Bogucka-Kocka, Anna
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.06.2024; MDPI
• Subjects: Adult; Aged; Angiogenesis; Body mass index; Cardiovascular disease; Care and treatment; Compression therapy; Coronary heart disease; Female; Gene Expression Regulation; Humans; Hypertension; Inflammation; Inflammation - blood; Inflammation - metabolism; Inflammation - pathology; Leukocytes; Leukocytes, Mononuclear - metabolism; Male; Middle Aged; Mortality; Neovascularization, Pathologic - metabolism; Performance evaluation; Plasma; Poland; Quality of life; Regression analysis; Taiwan; Varicose veins; Varicose Veins - blood; Varicose Veins - metabolism; Varicose Veins - pathology; Vascular endothelial growth factor; Poland; Taiwan; chronic venous disease; plasma proteins; inflammation; varicose veins; angiogenesis; gene expression

Varicose veins (VVs) are the most common manifestation of chronic venous disease (CVD) and appear as abnormally enlarged and tortuous superficial veins. VVs result from functional abnormalities in the venous circulation of the lower extremities, such as venous hypertension, venous valve incompetence...