Clinical and genetic heterogeneity in a large cohort of Armenian patients with late-onset familial Mediterranean fever

• Published in: Genetics in medicine Vol. 20; no. 12; pp. 1583 - 1588
• Main Authors: Kriegshäuser, Gernot, Enko, Dietmar, Hayrapetyan, Hasmik, Atoyan, Stepan, Oberkanins, Christian, Sarkisian, Tamara
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.12.2018; Nature Publishing Group US; Elsevier Limited
• Subjects: Adult; Aged; Armenia - epidemiology; Biomedical and Life Sciences; Biomedicine; disease phenotype; familial Mediterranean fever; Familial Mediterranean Fever - epidemiology; Familial Mediterranean Fever - genetics; Familial Mediterranean Fever - physiopathology; Female; Fever; Genetic Heterogeneity; Genetic Predisposition to Disease; Genotype; Human Genetics; Humans; Laboratory Medicine; late onset; Male; MEFV mutation; Middle Aged; Mutation; Phenotype; Pyrin - genetics; Armenia; familial Mediterranean fever; late onset; MEFV mutation; disease phenotype; mutation

This work aimed at investigating demographic, clinical, and genetic characteristics of individuals experiencing their first familial Mediterranean fever (FMF) attack at age ≥40 years in a very large cohort of Armenian FMF patients. In total, 10,370 Armenian patients diagnosed with FMF based on the T...