Elimination rate constant describing clearance of infused fluid from plasma is independent of large infusion volumes of 0.9% saline in sheep

• Published in: Anesthesiology (Philadelphia) Vol. 101; no. 3; pp. 666 - 674
• Main Authors: SVENSEN, Christer H, BRAUER, Kirk P, HAHN, Robert G, UCHIDA, Tatsuo, TRABER, Lillian D, TRABER, Daniel L, PROUGH, Donald S
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.09.2004
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Inhalation; Animals; Area Under Curve; Biological and medical sciences; Body Fluid Compartments - physiology; Crystalloid Solutions; Female; Hemodynamics - drug effects; Hemoglobins - metabolism; Infusions, Intravenous; Isoflurane; Isotonic Solutions; Medical sciences; Medicin och hälsovetenskap; Plasma Substitutes - administration & dosage; Plasma Substitutes - pharmacology; Sheep; Sodium Chloride - administration & dosage; Sodium Chloride - pharmacokinetics; Anesthesia; Sheep; Vertebrata; Mammalia; Artiodactyla; Ungulata

The purpose of this study was to determine the influence of varying large crystalloid infusion volumes, ranging from a volume that has been safely administered to volunteers to a volume that greatly exceeds a practical volume for studies in normovolemic humans, of rapidly infused 0.9% saline on the...