Causal Effects of YKL‐40 on Ischemic Stroke and Its Subtypes: A 2‐Sample Mendelian Randomization Study

• Published in: Journal of the American Heart Association Vol. 12; no. 17; p. e029000
• Main Authors: Xu, Qingyun, Sun, Lulu, Wang, Yinan, Wang, Ruirui, Jia, Yiming, Guo, Daoxia, Shi, Mengyao, Yang, Pinni, Zhang, Yonghong, Zhu, Zhengbao
• Format: Journal Article
• Language: English
• Published: Hoboken John Wiley and Sons Inc 05.09.2023; Wiley
• Subjects: large artery stroke; Mendelian randomization; Original Research; small vessel stroke; YKL‐40

Background Chitinase-3 like protein 1 (CHI3L1, YKL-40) was reported to be implicated in the development of ischemic stroke, but whether the association between them was causal remained unclear. We conducted a 2-sample Mendelian randomization study to explore the associations of genetically determine...