Specific and sensitive GC–MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study - Baskal, Svetlana; Kaiser, Annette; Mels, Catharina; Kruger, Ruan; Tsikas, Dimitrios (Amino acids, 2022)
Keywords: Acetic acid; Acylation; advanced glycation end products; Advanced glycosylation end products; Amino acids; Analytical Chemistry; anhydrides; Biochemical Engineering; Biochemistry; Biomarkers; Biomedical and Life Sciences; Creatinine; derivatization; detection limit; Deuterium; Esterification; Esters; Ethnic factors; Ethyl acetate; Excretion; females; Gas chromatography; gas chromatography-mass spectrometry; Glycosylation; Initiation factor eIF-5A; Ionization; Life Sciences; Lysine; males; Mass spectrometry; Mass spectroscopy; Neurobiology; Original; Original Article; Post-translation; post-translational modification; progeny; Proteomics; Stiffness; Urine; Deuterium; GC–MS; Quantification; ASOS; Amino acids; AGEs; Derivatization; Post-translational modification (PTM); eIF5A; Hypusine