Promising Potential of Lonchocarpus utilis against South American Myasis
Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation....
Saved in:
| Published in | Plants (Basel) Vol. 9; no. 1; p. 33 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
25.12.2019
MDPI |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of
against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine). |
|---|---|
| AbstractList | Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of Lonchocarpus utilis against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine).Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of Lonchocarpus utilis against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine). Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of Lonchocarpus utilis against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine). Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of Lonchocarpus utilis against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine). Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine). |
| Author | Blanco-Salas, José Alías-Gallego, Juan Carlos Luzuriaga-Quichimbo, Carmen X Cerón-Martínez, Carlos E Ruiz-Téllez, Trinidad |
| AuthorAffiliation | 1 Faculty of Health Sciences Eugenio Espejo, University UTE, Quito 170147, Ecuador; luzuriaga.cx@gmail.com 2 Área de Botánica, Facultad de Ciencias, Universidad de Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain; truiz@unex.es 3 Herbarium Alfredo Paredes, QAP, Ecuador Central University UCE, Quito 170521, Ecuador; carlosceron57@hotmail.com 4 Área de Ecología, Facultad de Ciencias, Universidad de Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain; jalias@unex.es |
| AuthorAffiliation_xml | – name: 2 Área de Botánica, Facultad de Ciencias, Universidad de Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain; truiz@unex.es – name: 3 Herbarium Alfredo Paredes, QAP, Ecuador Central University UCE, Quito 170521, Ecuador; carlosceron57@hotmail.com – name: 1 Faculty of Health Sciences Eugenio Espejo, University UTE, Quito 170147, Ecuador; luzuriaga.cx@gmail.com – name: 4 Área de Ecología, Facultad de Ciencias, Universidad de Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain; jalias@unex.es |
| Author_xml | – sequence: 1 givenname: Carmen X orcidid: 0000-0002-2579-2927 surname: Luzuriaga-Quichimbo fullname: Luzuriaga-Quichimbo, Carmen X organization: Faculty of Health Sciences Eugenio Espejo, University UTE, Quito 170147, Ecuador – sequence: 2 givenname: José orcidid: 0000-0001-6525-4448 surname: Blanco-Salas fullname: Blanco-Salas, José organization: Área de Botánica, Facultad de Ciencias, Universidad de Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain – sequence: 3 givenname: Carlos E surname: Cerón-Martínez fullname: Cerón-Martínez, Carlos E organization: Herbarium Alfredo Paredes, QAP, Ecuador Central University UCE, Quito 170521, Ecuador – sequence: 4 givenname: Juan Carlos orcidid: 0000-0001-8137-0369 surname: Alías-Gallego fullname: Alías-Gallego, Juan Carlos organization: Área de Ecología, Facultad de Ciencias, Universidad de Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain – sequence: 5 givenname: Trinidad orcidid: 0000-0001-8829-1559 surname: Ruiz-Téllez fullname: Ruiz-Téllez, Trinidad organization: Área de Botánica, Facultad de Ciencias, Universidad de Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31881648$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkV1rHCEUhqWkNJ-XvS0DvenNpEePozM3hRCaD9jSQNNrcRxn12VWt-oU8u9rsknIVgQP-vDgOe8xOfDBW0I-UjhH7ODrdtI-pw4oAOI7csQYw1pKLg_e1IfkLKU1lNWWTcUHcoi0LQVvj8jNXQwbl5xfVnchW5-dnqowVovgzSoYHbdzqubsJpcqvdTOp1z9CnNeVRcbG53RvvrxoJNLp-T9qKdkz57PE_L76vv95U29-Hl9e3mxqA1HmWsujLEouGkkWtODHMDwQQx9g9Db0QJvBLN0MEg70XAcBkHLdWebkbd81HhCbnfeIei12ka30fFBBe3U00WIS6VjdmayCozVOAqgrUSOLdWmlx1FGEVxagbF9W3n2s79xg6mtB_1tCfdf_FupZbhr5LAgDaPgi_Pghj-zDZlVWZp7FRisWFOiiFS1jSMyYJ-_g9dhzn6MipVCGDIWcsLVe8oE0NK0Y6vn6GgHiNXe5EX_tPbDl7pl4DxH7AYqgQ |
| Cites_doi | 10.1007/s11010-017-3202-y 10.1248/cpb.56.93 10.1016/j.bjp.2017.11.009 10.1093/jnci/dji377 10.1016/j.bjp.2018.08.004 10.1016/S0378-8741(99)00036-7 10.1111/j.1365-2141.2005.05504.x 10.3354/meps206227 10.1016/j.tetlet.2005.11.069 10.1021/jf981188x 10.1248/cpb.c13-00385 10.1002/ijc.25949 10.1016/j.bjp.2017.07.006 10.1016/S1473-3099(14)70835-7 10.1016/j.tetlet.2008.02.063 10.1016/j.jep.2004.01.011 10.1093/nar/gku293 10.1021/tx049867r 10.1371/journal.pntd.0002865 10.1371/journal.pmed.1000097 10.1038/onc.2012.413 10.5352/JLS.2015.25.12.1377 10.1016/j.trstmh.2005.06.020 10.1073/pnas.95.7.3380 10.1158/1940-6207.CAPR-2-2-COR 10.1016/j.tetlet.2010.09.057 10.1016/S0001-7310(01)76539-8 10.1021/np50044a013 10.1590/S0103-50532010001000007 10.1016/j.ijantimicag.2007.08.023 10.1096/fj.201700288R 10.1016/S0959-8049(02)00192-2 10.1093/bioinformatics/btt540 10.1038/nrmicro1048 10.1016/j.bjp.2017.11.007 10.1067/mjd.2003.37 10.1016/S0001-7310(06)73346-4 10.1021/np990623u 10.1038/s41587-019-0053-y 10.1166/asem.2014.1630 10.1016/j.bjp.2015.01.004 10.1590/S0103-50532012005000065 10.17352/ojps.000001 10.1016/j.bjp.2015.07.002 10.1016/S1473-3099(14)70830-8 |
| ContentType | Journal Article |
| Copyright | 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 by the authors. 2019 |
| Copyright_xml | – notice: 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2019 by the authors. 2019 |
| DBID | NPM AAYXX CITATION 3V. 7SN 7SS 7T7 7X2 8FD 8FE 8FH 8FK ABUWG AFKRA ATCPS AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 GNUQQ HCIFZ LK8 M0K M7P P64 PATMY PIMPY PQEST PQQKQ PQUKI PRINS PYCSY 7X8 5PM DOA |
| DOI | 10.3390/plants9010033 |
| DatabaseName | PubMed CrossRef ProQuest Central (Corporate) Ecology Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Agricultural Science Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database ProQuest Central Student SciTech Premium Collection Biological Sciences Agriculture Science Database Biological Science Database Biotechnology and BioEngineering Abstracts Environmental Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Environmental Science Collection MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student Technology Research Database ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central Natural Science Collection ProQuest Central Korea Agricultural & Environmental Science Collection Biological Science Collection Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection Biological Science Database ProQuest SciTech Collection Ecology Abstracts Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts ProQuest One Academic UKI Edition Environmental Science Database Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef Agricultural Science Database PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Botany Medicine |
| EISSN | 2223-7747 |
| ExternalDocumentID | oai_doaj_org_article_0cea3f6018734381acb79130f661ea20 10_3390_plants9010033 31881648 |
| Genre | Journal Article |
| GeographicLocations | Guyana Ecuador |
| GeographicLocations_xml | – name: Guyana – name: Ecuador |
| GrantInformation_xml | – fundername: the Government of Extremadura (Spain) and the European Union through the action "Apoyos a los Planes de Actuación de los Grupos de Investigación Catalogados de la Junta de Extremadura: FEDER GR18169". grantid: GR18169 |
| GroupedDBID | 5VS 7X2 7XC 8FE 8FH AADQD AAHBH ADBBV AFKRA AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS ATCPS BBNVY BCNDV BENPR BHPHI CCPQU ECGQY GROUPED_DOAJ HCIFZ HYE KQ8 LK8 M0K M48 M7P MODMG M~E NPM OK1 PATMY PGMZT PIMPY PROAC PYCSY RIG RPM AAYXX CITATION 3V. 7SN 7SS 7T7 8FD 8FK ABUWG AZQEC C1K DWQXO FR3 GNUQQ P64 PQEST PQQKQ PQUKI PRINS 7X8 OZF 5PM |
| ID | FETCH-LOGICAL-c437t-46cce364c573ecb07d0c4d6db530befe04562e1dc3196543dd61efe9e5f484fa3 |
| IEDL.DBID | RPM |
| ISSN | 2223-7747 |
| IngestDate | Fri Oct 04 13:12:03 EDT 2024 Tue Sep 17 20:46:40 EDT 2024 Sat Aug 17 04:25:36 EDT 2024 Thu Oct 10 16:50:17 EDT 2024 Fri Aug 23 05:29:29 EDT 2024 Fri Oct 18 08:51:52 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | bioinformatic in silico drug discovery rotenoid Lonchocarpus utilis barbasco |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c437t-46cce364c573ecb07d0c4d6db530befe04562e1dc3196543dd61efe9e5f484fa3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8137-0369 0000-0001-8829-1559 0000-0001-6525-4448 0000-0002-2579-2927 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020150/ |
| PMID | 31881648 |
| PQID | 2550234284 |
| PQPubID | 2032347 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_0cea3f6018734381acb79130f661ea20 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7020150 proquest_miscellaneous_2331255227 proquest_journals_2550234284 crossref_primary_10_3390_plants9010033 pubmed_primary_31881648 |
| PublicationCentury | 2000 |
| PublicationDate | 20191225 |
| PublicationDateYYYYMMDD | 2019-12-25 |
| PublicationDate_xml | – month: 12 year: 2019 text: 20191225 day: 25 |
| PublicationDecade | 2010 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Plants (Basel) |
| PublicationTitleAlternate | Plants (Basel) |
| PublicationYear | 2019 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Ginarte (ref_18) 1996; 87 Jara (ref_28) 2018; 28 Mangul (ref_30) 2019; 37 Wang (ref_53) 2018; 442 Lawson (ref_35) 2016; 1 Bortul (ref_54) 2005; 129 ref_12 ref_11 ref_10 Omura (ref_58) 2008; 31 Fang (ref_31) 1999; 47 Muhaisen (ref_40) 2014; 6 Katewa (ref_2) 2004; 92 Fuchino (ref_45) 2008; 56 ref_15 Lee (ref_48) 2015; 25 McGarry (ref_62) 2014; 14 Caboni (ref_41) 2004; 17 Mengarelli (ref_17) 2012; 93 ref_61 Fuchino (ref_42) 2013; 61 Ackerman (ref_55) 2000; 206 Preston (ref_46) 2017; 31 (ref_13) 2009; 22 Mishra (ref_26) 2017; 27 Murillo (ref_49) 2002; 38 ref_67 Lawson (ref_37) 2008; 49 Lee (ref_50) 2005; 97 ref_64 ref_63 Rubio (ref_21) 2006; 97 Thamilselvan (ref_52) 2011; 129 Manrique (ref_20) 2009; 20 Fang (ref_39) 1998; 95 Kaouadji (ref_38) 1986; 49 Tamir (ref_14) 2003; 48 Sarwar (ref_44) 2015; 1 Chan (ref_23) 2005; 99 Lawson (ref_34) 2010; 51 (ref_6) 2013; 22 Moya (ref_24) 2007; 57 Crump (ref_59) 2004; 2 Ibrahim (ref_43) 2000; 69 Boreddy (ref_51) 2013; 32 Henriques (ref_27) 2015; 25 Silva (ref_60) 2002; 66 Silva (ref_32) 2012; 23 Lobo (ref_57) 2010; 21 Zaracho (ref_19) 2005; 38 Izquierdo (ref_22) 2001; 92 Aladdin (ref_56) 2018; 28 Aguilera (ref_16) 2002; 46 Fang (ref_36) 2000; 63 Gfeller (ref_66) 2014; 42 ref_1 ref_3 Lawson (ref_33) 2006; 47 Gfeller (ref_65) 2013; 29 Kim (ref_47) 2009; 2 ref_9 Borgtoft (ref_8) 1998; 3 ref_5 ref_4 ref_7 Lima (ref_25) 2015; 25 Shokrzadeh (ref_29) 2018; 28 |
| References_xml | – volume: 442 start-page: 177 year: 2018 ident: ref_53 article-title: Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox) publication-title: Mol. Cell. Biochem. doi: 10.1007/s11010-017-3202-y contributor: fullname: Wang – volume: 56 start-page: 93 year: 2008 ident: ref_45 article-title: A New Leishmanicidal Saponin from Brunfelsia grandiflora publication-title: Chem. Pharm. Bull. (Tokyo) doi: 10.1248/cpb.56.93 contributor: fullname: Fuchino – ident: ref_9 – ident: ref_5 – volume: 28 start-page: 34 year: 2018 ident: ref_28 article-title: Rhodolirium andicola: A new renewable source of alkaloids with acetylcholinesterase inhibitory activity, a study from nature to molecular docking publication-title: Rev. Bras. Farm. doi: 10.1016/j.bjp.2017.11.009 contributor: fullname: Jara – volume: 97 start-page: 1695 year: 2005 ident: ref_50 article-title: Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/dji377 contributor: fullname: Lee – volume: 28 start-page: 697 year: 2018 ident: ref_56 article-title: Antifungal activity of extracts and phenolic compounds from Deguelia duckeana publication-title: Rev. Bras. Farm. doi: 10.1016/j.bjp.2018.08.004 contributor: fullname: Aladdin – volume: 69 start-page: 99 year: 2000 ident: ref_43 article-title: Effect of Tephrosia vogelii and Justicia extensa on Tilapia nilotica in vivo publication-title: J. Ethnopharmacol. doi: 10.1016/S0378-8741(99)00036-7 contributor: fullname: Ibrahim – volume: 129 start-page: 677 year: 2005 ident: ref_54 article-title: PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.2005.05504.x contributor: fullname: Bortul – volume: 206 start-page: 227 year: 2000 ident: ref_55 article-title: Reef fish assemblages: A re-evaluation using enclosed rotenone stations publication-title: Mar. Ecol. Prog. Ser. doi: 10.3354/meps206227 contributor: fullname: Ackerman – volume: 47 start-page: 451 year: 2006 ident: ref_33 article-title: Substituted tubaic acids, new oxidative rotenoid metabolites from Lonchocarpus nicou publication-title: Tetrahedron Lett. doi: 10.1016/j.tetlet.2005.11.069 contributor: fullname: Lawson – volume: 47 start-page: 2130 year: 1999 ident: ref_31 article-title: Cube resin insecticide: Identification and biological activity of 29 rotenoid constituents publication-title: J. Agric. Food Chem. doi: 10.1021/jf981188x contributor: fullname: Fang – volume: 87 start-page: 340 year: 1996 ident: ref_18 article-title: Miasis cutánea por Dermatobia hominis publication-title: Actas Dermosifiliogr. contributor: fullname: Ginarte – volume: 61 start-page: 979 year: 2013 ident: ref_42 article-title: New Leishmanicidal Stilbenes from a Peruvian Folk Medicine, Lonchocarpus nicou publication-title: Chem. Pharm. Bull. (Tokyo) doi: 10.1248/cpb.c13-00385 contributor: fullname: Fuchino – volume: 129 start-page: 2916 year: 2011 ident: ref_52 article-title: Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 beta/beta-catenin pathway publication-title: Int. J. Cancer doi: 10.1002/ijc.25949 contributor: fullname: Thamilselvan – ident: ref_61 – ident: ref_1 – volume: 27 start-page: 724 year: 2017 ident: ref_26 article-title: Isolation and identification of cytotoxic compounds from a fruticose lichen Roccella montagnei, and it’s in silico docking study against CDK-10 publication-title: Rev. Bras. Farm. doi: 10.1016/j.bjp.2017.07.006 contributor: fullname: Mishra – ident: ref_12 doi: 10.1016/S1473-3099(14)70835-7 – volume: 1 start-page: 123 year: 2015 ident: ref_44 article-title: The killer chemicals for control of agriculture insect pests: The botanical insecticides publication-title: Int. J. Chem. Biomol. Sci. contributor: fullname: Sarwar – volume: 49 start-page: 2407 year: 2008 ident: ref_37 article-title: Nor-dehydrodeguelin and nor-dehydrorotenone, C(22) coumaronochromones from Lonchocarpus nicou publication-title: Tetrahedron Lett. doi: 10.1016/j.tetlet.2008.02.063 contributor: fullname: Lawson – volume: 38 start-page: 62 year: 2005 ident: ref_19 article-title: Invermectina in the treatment of Human Miasis publication-title: La Fac. Cienc. Médicas contributor: fullname: Zaracho – volume: 92 start-page: 41 year: 2004 ident: ref_2 article-title: Folk herbal medicines from tribal area of Rajasthan, India publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2004.01.011 contributor: fullname: Katewa – volume: 42 start-page: 32 year: 2014 ident: ref_66 article-title: SwissTargetPrediction: A web server for target prediction of bioactive small molecules publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku293 contributor: fullname: Gfeller – ident: ref_10 – volume: 17 start-page: 1540 year: 2004 ident: ref_41 article-title: Rotenone, deguelin, their metabolites, and the rat model of Parkinson’s disease publication-title: Chem. Res. Toxicol. doi: 10.1021/tx049867r contributor: fullname: Caboni – ident: ref_4 doi: 10.1371/journal.pntd.0002865 – volume: 22 start-page: 41 year: 2013 ident: ref_6 article-title: Estudio de la extracción del follaje de Barbasco (Lonchocarpus nicou) como fuente biocida (en condiciones de la Amazonía en Ecuador) publication-title: Rev. Cienc. Técnicas Agropecu. – ident: ref_64 doi: 10.1371/journal.pmed.1000097 – volume: 32 start-page: 3980 year: 2013 ident: ref_51 article-title: Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model publication-title: Oncogene doi: 10.1038/onc.2012.413 contributor: fullname: Boreddy – volume: 57 start-page: 217 year: 2007 ident: ref_24 article-title: Miasis cutánea Revisión sobre el tema y presentación de un caso de miasis forunculoide publication-title: Arch. Argent. Derm. contributor: fullname: Moya – volume: 25 start-page: 1377 year: 2015 ident: ref_48 article-title: Anti-inflammatory Effect of Scopoletin in RAW264.7 Macrophages publication-title: J. Life Sci. doi: 10.5352/JLS.2015.25.12.1377 contributor: fullname: Lee – volume: 99 start-page: 914 year: 2005 ident: ref_23 article-title: Unusual cases of human myiasis due to Old World screwworm fly acquired indoors in Hong Kong publication-title: Trans. R. Soc. Trop. Med. Hyg. doi: 10.1016/j.trstmh.2005.06.020 contributor: fullname: Chan – volume: 95 start-page: 3380 year: 1998 ident: ref_39 article-title: Anticancer action of cube insecticide: Correlation for rotenoid constituents between inhibition of NADH: Ubiquinone oxidoreductase and induced ornithine decarboxylase activities publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.7.3380 contributor: fullname: Fang – ident: ref_7 – volume: 46 start-page: 280 year: 2002 ident: ref_16 article-title: Miasis furunculoide publication-title: Comun. Caso. Dermatol. Rev. Mex contributor: fullname: Aguilera – volume: 2 start-page: 186 year: 2009 ident: ref_47 article-title: A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy publication-title: Cancer Prev. Res. doi: 10.1158/1940-6207.CAPR-2-2-COR contributor: fullname: Kim – ident: ref_3 – volume: 51 start-page: 6116 year: 2010 ident: ref_34 article-title: A single chalcone and additional rotenoids from Lonchocarpus nicou publication-title: Tetrahedron Lett. doi: 10.1016/j.tetlet.2010.09.057 contributor: fullname: Lawson – ident: ref_11 – volume: 92 start-page: 456 year: 2001 ident: ref_22 article-title: Miasis forunculoide: Descripción de dos casos con estudio histológico de las diferentes larvas publication-title: Actas Dermosifiliogr. doi: 10.1016/S0001-7310(01)76539-8 contributor: fullname: Izquierdo – volume: 49 start-page: 281 year: 1986 ident: ref_38 article-title: Lonchocarpene, a stilbene, and lonchocarpusone, an isoflavone—2 new pyronopolyphenols from Lonchocarpus nicou roots publication-title: J. Nat. Prod. doi: 10.1021/np50044a013 contributor: fullname: Kaouadji – volume: 21 start-page: 1838 year: 2010 ident: ref_57 article-title: Stilbenes from Deguelia rufescens var. urucu (Ducke) A. M. G. Azevedo Leaves: Effects on Seed Germination and Plant Growth publication-title: J. Braz. Chem. Soc. doi: 10.1590/S0103-50532010001000007 contributor: fullname: Lobo – volume: 22 start-page: 121 year: 2009 ident: ref_13 article-title: Miasis: Un problema de salud poco estudiado en México publication-title: Rev. Enferm. Infecc. Pediatr. – ident: ref_67 – volume: 3 start-page: 1 year: 1998 ident: ref_8 article-title: People and Biodiversity. Two case studies from the Andean foothills of Ecuador. Centre for research on cultural and biological diversity of Andean rainforests publication-title: Diva Tech. Rep. contributor: fullname: Borgtoft – ident: ref_63 – volume: 66 start-page: 4 year: 2002 ident: ref_60 article-title: Insecticidas vegetales; una vieja y nueva alternativa en el manejo de insectos publication-title: Rev. Manejo Integr. Plagas Agroecol. contributor: fullname: Silva – volume: 31 start-page: 91 year: 2008 ident: ref_58 article-title: Ivermectin: 25 years and still going strong publication-title: Int. J. Antimicrob. Agents doi: 10.1016/j.ijantimicag.2007.08.023 contributor: fullname: Omura – volume: 31 start-page: 4515 year: 2017 ident: ref_46 article-title: Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain publication-title: FASEB J. doi: 10.1096/fj.201700288R contributor: fullname: Preston – volume: 38 start-page: 2446 year: 2002 ident: ref_49 article-title: Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest publication-title: Eur. J. Cancer doi: 10.1016/S0959-8049(02)00192-2 contributor: fullname: Murillo – volume: 29 start-page: 3073 year: 2013 ident: ref_65 article-title: Shaping the interaction landscape of bioactive molecules publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt540 contributor: fullname: Gfeller – volume: 2 start-page: 984 year: 2004 ident: ref_59 article-title: The life and times of ivermectin—a success story publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro1048 contributor: fullname: Crump – volume: 28 start-page: 27 year: 2018 ident: ref_29 article-title: Cytotoxic activity of abietane diterpenoids from roots of Salvia sahendica by HPLC-based activity profiling publication-title: Rev. Bras. Farm. doi: 10.1016/j.bjp.2017.11.007 contributor: fullname: Shokrzadeh – volume: 48 start-page: 630 year: 2003 ident: ref_14 article-title: Dermatobia hominis myiasis among travelers returning from South America publication-title: J. Am. Acad. Derm. doi: 10.1067/mjd.2003.37 contributor: fullname: Tamir – volume: 97 start-page: 39 year: 2006 ident: ref_21 article-title: Miasis cutáneas sobre lesiones tumorales: Presentación de tres casos publication-title: Actas Dermosifiliogr. doi: 10.1016/S0001-7310(06)73346-4 contributor: fullname: Rubio – volume: 63 start-page: 293 year: 2000 ident: ref_36 article-title: New bioactive flavonoids and stilbenes in cube resin insecticide publication-title: J. Nat. Prod. doi: 10.1021/np990623u contributor: fullname: Fang – volume: 37 start-page: 324 year: 2019 ident: ref_30 article-title: How bioinformatics and open data can boost basic science in countries and universities with limited resources publication-title: Nat. Biotechnol. doi: 10.1038/s41587-019-0053-y contributor: fullname: Mangul – ident: ref_15 – volume: 6 start-page: 1 year: 2014 ident: ref_40 article-title: Introduction and Interpretation of Flavonoids publication-title: Adv. Sci. Eng. Med. doi: 10.1166/asem.2014.1630 contributor: fullname: Muhaisen – volume: 25 start-page: 7 year: 2015 ident: ref_25 article-title: Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity publication-title: Rev. Bras. Farm. doi: 10.1016/j.bjp.2015.01.004 contributor: fullname: Lima – volume: 23 start-page: 1933 year: 2012 ident: ref_32 article-title: Flavonoids from the Leaves of Deguelia utilis (Leguminosae): Structural Elucidation and Neuroprotective Properties publication-title: J. Braz. Chem. Soc. doi: 10.1590/S0103-50532012005000065 contributor: fullname: Silva – volume: 1 start-page: 1 year: 2016 ident: ref_35 article-title: O-Benzoquinone and Ester-Linked Hydroxyfatatty Acid as Additional compounds from Lonchocarpus nicou publication-title: Open J. Plant Sci. doi: 10.17352/ojps.000001 contributor: fullname: Lawson – volume: 93 start-page: 1 year: 2012 ident: ref_17 article-title: Manejo de las miasis en heridas agudas y crónicas: Presentación de casos y revisión de la bibliografía publication-title: Rev. Argent. Dermatol. Ciudad Autónoma Buenos Aires contributor: fullname: Mengarelli – volume: 25 start-page: 382 year: 2015 ident: ref_27 article-title: The catechol-O-methyltransferase inhibitory potential of Z-vallesiachotamine by in silico and in vitro approaches publication-title: Rev. Bras. Farm. doi: 10.1016/j.bjp.2015.07.002 contributor: fullname: Henriques – volume: 20 start-page: 23 year: 2009 ident: ref_20 article-title: Miasis cutánea: Reporte de un caso y revisión de la literatura publication-title: Folia Derm. Peru contributor: fullname: Manrique – volume: 14 start-page: 672 year: 2014 ident: ref_62 article-title: Tropical myiases: Neglected and well travelled publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(14)70830-8 contributor: fullname: McGarry |
| SSID | ssj0000800816 |
| Score | 2.161284 |
| Snippet | Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected... |
| SourceID | doaj pubmedcentral proquest crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 33 |
| SubjectTerms | barbasco bioinformatic Cytochrome drug discovery Flavonoids in silico Isoflavonoids Lonchocarpus utilis Medicine Parasites Parasitic diseases Proteins rotenoid Traditional medicine Tropical diseases |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8NAEB6kePAivo0vVhBvwaT7ao4qliJWerDQW9hsJlqRpJj24L93NklLI4IXr9ll2czM7nwfO3wDcEWsStlESx-lsr5QhOFMhMq3NsRMUFgHlZTS8FkNxuJxIidrrb5cTVgtD1wb7iawaHimXO847uSoDK0c0cWbUWJB063ZeijXyNR7g4N6oapFNTnx-pvZh6srccUIAeetJFRp9f8GMH_WSa4lnv4ObDeIkd3WO92FDcz3YPOuIFT3tQ-D0WdBrqIExEbF3JX-0NwiY09FThebe11ZlIyC62NaMvNqpoQGWdU2jy3fatjwy5TT8gDG_YeX-4HfdEfwreB6Tna1FrkSVmqONgl0Gljh2kNJHiSYYcVtMEytO2RS8DQlg2UYocxET2SGH0InL3I8BmZlqBObKkr1ieDubdTJpBkVRV0dGo0eXC_NFc9qEYyYyIOza9yyqwd3zpirSU67uvpAHo0bj8Z_edSDs6Ur4uZAlTExH0IXxJWEB5erYbKve98wORYLmsM5wTUClNqDo9pzq53Q1UXxIHoe6JZPW1ttj-TTt0puWxOiJth88h__dgpbtFjVgKIrz6Az_1zgOaGaeXJRBfA3KSj1eg priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9RAEB-0FfFFtH6lVllBfAtNbr8uT-JJyyFeOcRC38JmM2kPSva83D30v-9Mbu80Ir5mN7DMzM78Zmf4DcBHyqqMr6xOURufKkMYzhVoUu9zbBSZddZTKc0uzPRSfbvSV_HBrYttlTuf2DvqOnh-Iz8l6EvhhcCy-rz8lfLUKK6uxhEaD-FwlCsu0x5Ozi7mP_avLIyHxrnZkmtKyu9Pl7fcX8JNCZmUg2DUc_b_C2j-3S_5RwA6fwZPI3IUX7aqfg4PsD2CR5NA6O7uCB7PYpH8BUznq0Dao5gk5mHN3UD0W2jE99CSr-OCy6YTZG-3i064a7cggCj6SXpiV74RszvXLbqXcHl-9vPrNI0DE1KvpF2TqL1HaZTXVqKvMltnXvHEKC2zChvs0x3Ma8_3TitZ14Y0ggXqRo1V4-QrOGhDi29AeJ3byteGon-lJJdLmTnNmaIY2dxZTODTTnLlcsuLUVI-wSIuByJOYMJy3W9iOuv-Q1hdl_F2lJlHJxvDAwIlc445Mp-ComtD6AHdKEvgZKeVMt6xrvxtEQl82C-TfLnk4VoMG9ojJSE4wpg2gddbJe5PQt6MTEONE7AD9Q6OOlxpFzc9A7clkE1I-vj_x3oLT2hbP21ipE_gYL3a4DuCMOvqfbTTe6eB8lM priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEB7RwKEXxKvFENBWQtxMnewrPiBEEVWEGtQDkXqz1utxmyqyQ5xI5N8zs3ECpj1w9a78mJn1fJ9m9A3AO2JVxudWx6iNj5UhDOdSNLH3AywVhXUSpJQm3814qr5d6as_kkKtAZt7qR3Pk5ou5x9-_dx8ogP_kRknUfbTxZxbRrjPIJHyAB4OlVQc7JMW6d-2wGgUBqFyQiRMqexWcfPuHToZKgj534c-_22i_CsrnT-Bxy2cFJ-3_n8KD7B6Bo_OaoJ8m-cwvlzW5EfKTuKyXnFfEO2tS3FRV_ThXHpZN4Iibz5rhLt2M4KKIszUE7tCjphsXDNrXsD0_OuPL-O4HZ0QeyXtiozuPUqjvLYSfZ7YIvGKZ0dpmeRYYiA-OCg8n0CtZFEY8g2mqEs1UqWTR9Cr6gpfgvB6YHNfGMIBuZJcOGUNNWfSdGgHzmIE73fmyhZbhYyMmAXbNevYNYIzNuZ-Ewtbhwv18jprz0mWeHSyNDwqULL6mKNASinPloQj0A2TCPo7V2S7YMmIFhH0ICKlIjjZL5N9ufjhKqzXtEdKwnKENm0Ex1vP7d-E_msUG2oUge34tPOq3ZVqdhO0uC3BbcLUr_7jua_hkPaG4RND3YfearnGN4RoVvnbEKu_AXGq9Ps priority: 102 providerName: Scholars Portal |
| Title | Promising Potential of Lonchocarpus utilis against South American Myasis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31881648 https://www.proquest.com/docview/2550234284 https://www.proquest.com/docview/2331255227/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC7020150 https://doaj.org/article/0cea3f6018734381acb79130f661ea20 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEB7y6KGXkvSpPMwGSm-KJe_LOsYhwZQ6mNJAbmK1GqUKjmQs-5B_n9m1ZOySUy8SaEewzIw032hG3wB8p6xK2UzLEKWyoVCE4UyCKrQ2xkKQW0eeSmlyp8b34ueDfNgD2f0L45v2bVZeVrPny6r863sr58-23_WJ9aeTa00Yh4BMfx_2NedbKfpTC4GGsVrzaXJK6fvzmWspcX0IEXdzc8iNScBN_NkKRZ6x_y2Y-W-35Fb4uT2CDy1uZFfr_R3DHlYf4d2oJmz38gnG00VNBqMwxKb10jUAkWxdsF91Ra83V2NZNYxcbFY2zDyakjAh88PzWFexYZMX05TNZ7i_vflzPQ7bGQmhFVwvSbvWIlfCSs3RZpHOIyvckCjJowwL9BkOxrl1j5oUPM8VGQETlIUYisLwL3BQ1RV-A2ZlrDObKwr4meCuQurI0oxKkoGOjcYAfnTqSudrKoyUUgin4nRHxQGMnDI3Qo7B2l-oF49pa8c0smh4odxMQO5oxgx5TEIBtSDAgGYQBXDWmSJtH6smpfyHMAZlTCKAi80y6ddVOUyF9YpkOCfQRrBSB_B1bbnNTjrLB6B3bLqz1d0V8kFPut363Ml_33kK7-nsZ08M5BkcLBcrPCdAs8x6cDi6uZv-7vkPAnSciGHPO_UrIMj6Cw |
| link.rule.ids | 230,315,733,786,790,870,891,2115,2236,21416,24346,27955,27956,33777,33778,43838,53825,53827,74657 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwED5Bh2AvEwzGwgYYCfEWLal_NU-ITpsKtFWFNmlvkeM4o9IUl6Z92H_PXeoWgiZe41iy7s533_lO3wF8xKxK2ULL2EllY6EQw5nMqdja1FUCzTppqZQmUzW6Ft9u5E14cGtCW-XWJ7aOuvSW3sjPEPpieEGwLD4vfsU0NYqqq2GExmPYI8rNQQ_2hhfT2Y_dKwvhoUGqNuSaHPP7s8Ud9ZdQU0LCeScYtZz9DwHNf_sl_wpAl8_hICBH9mWj6hfwyNWH8GToEd3dH8LTSSiSv4TRbOlRexiT2MyvqBsIt_mKjX2Nvo4KLuuGob3dzRtmbs0cASJrJ-mxbfmGTe5NM29ewfXlxdX5KA4DE2IruF6hqK11XAkrNXe2SHSZWEEToyRPCle5Nt1xaWnp3knBy1KhRlzmZCUGojL8CHq1r90xMCtTXdhSYfQvBKdyKTGnGZVlfZ0a7SL4tJVcvtjwYuSYT5CI846IIxiSXHc_EZ11-8Evb_NwO_LEOsMrRQMCOXGOGTSfDKNrhejBmX4SwelWK3m4Y03-xyIi-LBbRvlSycPUzq_xH84RwSHG1BG83ihxdxL0ZmgaYhCB7qi3c9TuSj3_2TJwawTZiKTf_P9Y7-HZ6Goyzsdfp99PYB-3tJMn-vIUeqvl2r1FOLMq3gWb_Q1ED_VJ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwED7BhiZepjFgZGxgJMRb1KT-1Twhuq0qsFYVYtLeIsdxRqUpLk37sP-eu9QtBCFe41iy7s533_lO3wG8x6xK2ULL2EllY6EQw5nMqdja1FUCzTppqZQmUzW-EV9u5W3of2pCW-XWJ7aOuvSW3sh7CH0xvCBYFr0qtEXMLkcfFz9jmiBFldYwTuMx7GuhJCZi-8Or6ezb7sWFsNEgVRuiTY65fm9xT70m1KCQcN4JTC1__79A59-9k38Eo9ERHAYUyT5t1P4MHrn6GJ4MPSK9h2M4mISC-XMYz5YeNYnxic38ijqDcJuv2LWv0e9R8WXdMLS9-3nDzJ2ZI1hk7VQ9ti3lsMmDaebNC7gZXX2_GMdheEJsBdcrFLu1jithpebOFokuEytoepTkSeEq16Y-Li0t3UEpeFkq1I7LnKzEQFSGv4S92tfuFTArU13YUiESKASn0imxqBmVZX2dGu0i-LCVXL7YcGTkmFuQiPOOiCMYklx3PxG1dfvBL-_ycFPyxDrDK0XDAjnxjxk0pQwjbYVIwpl-EsHZVit5uG9N_ts6Ini3W0b5UvnD1M6v8R_OEc0h3tQRnGyUuDsJejY0DTGIQHfU2zlqd6We_2jZuDUCbkTVp_8_1ls4QHPNrz9Pv76Gp7ijHULRl2ewt1qu3Tkim1XxJpjsL58M-X0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Promising+Potential+of+Lonchocarpus+utilis+against+South+American+Myasis&rft.jtitle=Plants+%28Basel%29&rft.au=Luzuriaga-Quichimbo%2C+Carmen+X&rft.au=Blanco-Salas%2C+Jos%C3%A9&rft.au=Cer%C3%B3n-Mart%C3%ADnez%2C+Carlos+E&rft.au=Al%C3%ADas-Gallego%2C+Juan+Carlos&rft.date=2019-12-25&rft.issn=2223-7747&rft.eissn=2223-7747&rft.volume=9&rft.issue=1&rft_id=info:doi/10.3390%2Fplants9010033&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2223-7747&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2223-7747&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2223-7747&client=summon |