Tetramethylpyrazine alleviates mitochondrial abnormality in models of cerebral ischemia and oxygen/glucose deprivation Reoxygenation

• Published in: Experimental neurology Vol. 367; p. 114468
• Main Authors: Chang, Cheng-Yi, Wu, Chih-Cheng, Pan, Pin-Ho, Wang, Ya-Yu, Lin, Shih-Yi, Liao, Su-Lan, Chen, Wen-Ying, Kuan, Yu-Hsiang, Chen, Chun-Jung
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2023
• Subjects: Animals; Brain Ischemia - drug therapy; Cerebral Infarction; ER stress; Glucose; Mitochondria - metabolism; Mitochondrial abnormality; Oxygen; Rats; Stroke; Tetramethylpyrazine; ER stress; Mitochondrial abnormality; Stroke; Tetramethylpyrazine

Traditional herbal medicine Ligusticum wallichii Franchat (Chuan Xiong) is frequently prescribed and highly recommended to patients with stroke. Rodent studies have demonstrated the neuroprotective effects of its active component tetramethylpyrazine against post-stroke brain injury and highlighted i...