cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides

• Published in: Carcinogenesis (New York) Vol. 16; no. 10; p. 2343
• Main Authors: Cai, J P, Kakuma, T, Tsuzuki, T, Sekiguchi, M
• Format: Journal Article
• Language: English
• Published: England 01.10.1995
• Subjects: Amino Acid Sequence; Animals; Bacteria - enzymology; Bacteria - genetics; Base Sequence; Cell Line; Cloning, Molecular; DNA Primers; DNA Repair Enzymes; DNA, Complementary; Escherichia coli - enzymology; Exons; Guanine Nucleotides - metabolism; Humans; Molecular Sequence Data; Mutation; Oxidation-Reduction; Phosphoric Monoester Hydrolases - chemistry; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - metabolism; Polymerase Chain Reaction; Proteus vulgaris - enzymology; Rats; Recombinant Proteins - metabolism; Restriction Mapping; RNA, Messenger - isolation & purification; RNA, Messenger - metabolism; Salmonella - enzymology; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid

The enzyme, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase (8-oxo-dGTPase), is present in various organisms and plays an important role in control of spontaneous mutagenesis. This enzyme degrades 8-oxoguanine-containing deoxyribonucleoside triphosphate, a potentially mutagenic substrate for DNA synt...