Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats

• Published in: World journal of gastroenterology : WJG Vol. 21; no. 7; pp. 2058 - 2066
• Main Authors: He, Qin, Li, Jin-Ke, Li, Fang, Li, Ru-Gui, Zhan, Guo-Qing, Li, Gang, Du, Wei-Xing, Tan, Hua-Bing
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 21.02.2015
• Subjects: Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; Basic Study; Biomarkers - blood; Blood Glucose - drug effects; Blood Glucose - metabolism; Cytochrome P-450 CYP1A1 - genetics; Cytochrome P-450 CYP1A1 - metabolism; diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Gynostemma; Gypenosides;Type; Insulin - blood; Lipids - blood; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; mellitus;Non-alcoholic; NF-kappa B - metabolism; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - pathology; Plant Extracts - pharmacology; PPAR gamma - genetics; PPAR gamma - metabolism; Rats, Sprague-Dawley; RNA, Messenger - metabolism; Time Factors; Tumor Necrosis Factor-alpha - metabolism; Non-alcoholic fatty liver; Type 2 diabetes mellitus; Gypenosides; Cytochrome P4501A1; PPARγ

AIM:To explore the mechanism of action of gypenosides(GPs)on type 2 diabetes mellitus and non-alcoholic fatty liver disease(T2DM-NAFLD)in rats.METHODS:Sixty rats were randomly divided into a healthy group,an untreated disease model group andGP-treatment groups.The study involved the evaluation of bi...