Subgenomic flaviviral RNAs: What do we know after the first decade of research

• Published in: Antiviral research Vol. 159; pp. 13 - 25
• Main Authors: Slonchak, Andrii, Khromykh, Alexander A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2018
• Subjects: Flavivirus; Noncoding RNA; sfRNA; Subgenomic flaviviral RNA; XRN-1 resistance; Subgenomic flaviviral RNA; Noncoding RNA; Flavivirus; sfRNA; XRN-1 resistance

The common feature of flaviviral infection is the accumulation of abundant virus-derived noncoding RNA, named flaviviral subgenomic RNA (sfRNA) in infected cells. This RNA represents a product of incomplete degradation of viral genomic RNA by the cellular 5′-3′ exoribonuclease XRN1 that stalls at th...