Role of CD56-expressing immature biliary epithelial cells in biliary atresia
AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were e...
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| Published in | World journal of gastroenterology : WJG Vol. 22; no. 8; pp. 2545 - 2557 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Baishideng Publishing Group Inc
28.02.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1007-9327 2219-2840 2219-2840 |
| DOI | 10.3748/wjg.v22.i8.2545 |
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| Abstract | AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. |
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| AbstractList | AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule (CD56) in patients with biliary atresia (BA).
METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.
RESULTS: Differences in some clinical laboratory parameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients (74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage (81.8%
vs
18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA.
CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule (CD56) in patients with biliary atresia (BA). Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts. Differences in some clinical laboratory parameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients (74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage (81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule (CD56) in patients with biliary atresia (BA).AIMTo analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule (CD56) in patients with biliary atresia (BA).Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.METHODSEstablished clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.Differences in some clinical laboratory parameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients (74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage (81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA.RESULTSDifferences in some clinical laboratory parameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients (74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage (81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA.The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA.CONCLUSIONThe maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. |
| Author | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia |
| AuthorAffiliation | Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University;Department of Pathology and Clinical Laboratory Guangzhou Women and Children’s Medical Center;Department of Surgery and Pathology, University of Hong Kong;Department of Life Sciences, Faculty of Natural Sciences, Imperial College London |
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| Cites_doi | 10.1016/S0140-6736(02)11603-5 10.1053/j.gastro.2004.09.004 10.1146/annurev-med-042909-093734 10.1055/s-2007-985068 10.1093/clinchem/31.6.797 10.1038/ng0797-243 10.1309/AJCPNRXCAP92KNOJ 10.1055/s-2007-964950 10.1002/hep.20858 10.1161/01.RES.0000266408.42939.e4 10.1186/gm154 10.1097/MEG.0b013e328356aee4 10.1136/ard.2010.134742 10.2353/ajpath.2006.050747 10.1371/journal.pone.0046512 10.1097/00000478-200311000-00008 10.1053/j.gastro.2007.04.031 10.1016/S0022-3468(97)90714-4 10.1002/hep.510240318 10.1007/978-1-59745-201-4_16 10.2353/ajpath.2007.070073 10.1016/S0140-6736(09)60946-6 10.1016/j.jpeds.2003.09.042 10.1038/nm.3282 10.1053/j.gastro.2010.07.042 |
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| Keywords | Epithelial cell adhesion molecule Biliary atresia Cytokeratin 7 Liver fibrosis Biliary epithelial cells CD56 |
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| Notes | Rui-Zhong Zhang;Jia-Kang Yu;Jiao Peng;Feng-Hua Wang;Hai-Ying Liu;Vincent CH Lui;John M Nicholls;Paul KH Tam;Jonathan R Lamb;Yan Chen;Hui-Min Xia;Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University;Department of Pathology and Clinical Laboratory Guangzhou Women and Children’s Medical Center;Department of Surgery and Pathology, University of Hong Kong;Department of Life Sciences, Faculty of Natural Sciences, Imperial College London ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Correspondence to: Yan Chen, PhD, Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong Province, China. ychenc@hku.hk Telephone: +86-20-38076560 Fax: +86-20-38076020 Author contributions: Zhang RZ and Yu JK contributed equally to this work; Zhang RZ and Peng J performed and analyzed the immunohistochemistry; Yu JK, Wang FH, and Liu HY provided and analyzed clinical samples and patient information; Lui VCH, Nicholls JM, Tam PKH, Lamb JR, Chen Y, and Xia HM contributed to study design, data collection, analysis, discussion, and manuscript preparation. |
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| Snippet | AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary... To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule (CD56) in patients with biliary atresia (BA).... To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule (CD56) in patients with biliary atresia (BA).AIMTo... AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule (CD56) in patients with biliary atresia (BA).... |
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| SubjectTerms | 7;Biliary adhesion atresia;CD56;Epithelial Basic Study Bile Ducts - chemistry Bile Ducts - pathology Biliary Biliary Atresia - blood Biliary Atresia - metabolism Biliary Atresia - pathology Bilirubin - blood CD56 Antigen - analysis cell cells;Liver Child Child, Preschool Choledochal Cyst - blood Choledochal Cyst - metabolism Choledochal Cyst - pathology epithelial Epithelial Cells - chemistry Epithelial Cells - pathology gamma-Glutamyltransferase - blood Hepatitis - blood Hepatitis - metabolism Hepatitis - pathology Humans Immunohistochemistry Infant Infant, Newborn Keratin-19 - analysis Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Male molecule;Cytokeratin Receptor, Notch1 - analysis Receptor, Notch2 - analysis Severity of Illness Index |
| Title | Role of CD56-expressing immature biliary epithelial cells in biliary atresia |
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