Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease

• Published in: World journal of gastroenterology : WJG Vol. 20; no. 4; pp. 1079 - 1087
• Main Author: Wang, Chao
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 28.01.2014
• Subjects: Adult; Animals; Apoptosis; B-cell; Brief; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Esophagogastric Junction - blood supply; Esophagogastric Junction - metabolism; Female; Humans; Hydrogen Sulfide - blood; hypertension; Hypertension, Portal - blood; Hypertension, Portal - parasitology; Hypertension, Portal - pathology; Liver - metabolism; Liver - pathology; Liver Cirrhosis, Experimental - metabolism; Liver Cirrhosis, Experimental - parasitology; lymphoma-2; Male; Middle Aged; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Portal; Portal Vein - metabolism; Portal Vein - pathology; Rabbits; Schistosomiasis - complications; Severity of Illness Index; Time Factors; Hydrogen sulfide; Cystathionine γ-lyase; B-cell lymphoma-XL; Portal hypertension; B-cell lymphoma-2; pERK 1/2; Apoptosis

AIM:To investigate the association between endogenous hydrogen sulfide(H2S)and portal hypertension as well as its effect on vascular smooth muscle cells.METHODS:Portal hypertension patients were categorized by Child-Pugh score based on bilirubin and albumin levels,prothrombin time,ascites and hepati...