In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

• Published in: Free radical biology & medicine Vol. 48; no. 1; pp. 136 - 144
• Main Authors: Butterfield, D. Allan, Galvan, Veronica, Lange, Miranda Bader, Tang, Huidong, Sowell, Renã A., Spilman, Patricia, Fombonne, Joanna, Gorostiza, Olivia, Zhang, Junli, Sultana, Rukhsana, Bredesen, Dale E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2010
• Subjects: Alzheimer disease; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Amyloid beta-Protein Precursor - metabolism; Amyloid β-peptide; Animals; Brain - metabolism; Brain - physiopathology; Disease Models, Animal; Free radicals; Humans; In vivo oxidative stress in brain; Male; Maze Learning; Methionine - metabolism; Methionine residue; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; Transgenic mouse model of Alzheimer disease; Free radicals; Methionine residue; Alzheimer disease; Transgenic mouse model of Alzheimer disease; In vivo oxidative stress in brain; Amyloid β-peptide

Numerous studies have demonstrated oxidative damage in the central nervous system in subjects with Alzheimer disease and in animal models of this dementing disorder. In this study, we show that transgenic mice modeling Alzheimer disease—PDAPP mice with Swedish and Indiana mutations in the human amyl...