Analysis of Specific Th1/Th2 Helper Cell Responses and IgG Subtype Antibodies in Anti-CD4 Monoclonal Antibody Treated Mice with Autoimmune Cardiomyopathy

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 28; no. 4; pp. 409 - 414
• Main Author: 汪朝晖 廖玉华 袁璟 张景辉 董继华 王金平
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.08.2008; Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China%Laboratory of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China%Institute of Virology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
• Subjects: ADP/ATP载体肽; Animals; Antibodies, Monoclonal - therapeutic use; Autoantibodies - blood; Autoimmune Diseases - immunology; Autoimmune Diseases - therapy; Cardiomyopathy, Dilated - immunology; Cardiomyopathy, Dilated - therapy; CD4; CD4 Antigens - immunology; CD4-Positive T-Lymphocytes - immunology; Immunoglobulin G - classification; Immunoglobulin G - immunology; Male; Medicine; Medicine & Public Health; Mice; Mice, Inbred BALB C; Mitochondrial ADP, ATP Translocases - immunology; Peptides - immunology; Th1 Cells - immunology; Th1/Th2免疫反应; Th2 Cells - immunology; 单克隆抗体; 自身免疫; CD4; autoimmunity; monoclonal antibody; Th1/Th2 immune response; ADP/ATP carrier peptides

The cytokine repertoire of ADP/ATP carrier-specific humoral immune responses and the cytokine-dependent anti-ADP/ATP carrier antibody IgG subclasses were examined in a cohort of ADP/ATP carrier-immunized BALB/c mice treated with anti-CD4 monoclonal antibody. Eighteen male BALB/c mice （6–8 weeks old）...