Analgesia for Early-Life Pain Prevents Deficits in Adult Anxiety and Stress in Rats

• Published in: Developmental neuroscience Vol. 37; no. 1; pp. 1 - 13
• Main Authors: Victoria, Nicole C., Karom, Mary C., Murphy, Anne Z.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2015
• Subjects: Aging; Analgesia; Animals; Animals, Newborn; Anxiety; Anxiety - drug therapy; Anxiety - physiopathology; Behavior, Animal - drug effects; Behavior, Animal - physiology; Female; Morphine - pharmacology; Original Paper; Pain - physiopathology; Pregnancy; Rats, Sprague-Dawley; Stress, Psychological - drug therapy; Stress, Psychological - physiopathology; Open Field; Morphine; Corticosterone; Long-term consequences; Forced Swim Test; Preterm infants

Previous studies in rats have established that inflammatory pain experienced on the day of birth (P0) decreases sensitivity to acute noxious, anxiety- and stress-provoking stimuli. However, to date, the impact of early-life pain on adult responses to chronic stress is not known. Further, the ability...