Longitudinal study of the association between smoking as a periodontitis risk and salivary biomarkers related to periodontitis
Insufficient data exist regarding the long-term influence of lifestyle factors including smoking on periodontal health. The objective of this study was to examine the prospective association between smoking and periodontal disease progression and the effects of smoking on salivary biomarkers related...
Saved in:
Published in | Journal of periodontology (1970) Vol. 78; no. 5; p. 859 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.05.2007
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Insufficient data exist regarding the long-term influence of lifestyle factors including smoking on periodontal health. The objective of this study was to examine the prospective association between smoking and periodontal disease progression and the effects of smoking on salivary biomarkers related to periodontitis.
Probing depth (PD) was measured at health checkups of workers in 1999 and 2003; additionally, lifestyle information was obtained through a questionnaire. In 2003, 219 of 256 (86%) workers examined at baseline completed PD measurements; saliva samples were also collected. Change in PD was used for assessment of periodontitis progression when three or more sites displayed an increase of >or=2 mm over 4 years. Salivary biomarker levels were determined by real-time polymerase chain reaction and enzyme assay. Statistical methods included bivariate and multivariate regression analyses.
In the multiple logistic model, in which lifestyle-related factors served as independent variables, significant variables were current smoking and hours of sleep; respective odds ratios were 2.3 and 2.1. Additionally, 38.5% of periodontal disease progression was attributable to current smoking. Moreover, pack-years of smoking showed a dose-response relationship with disease progression. Levels of salivary markers including prostaglandin E(2), lactoferrin, albumin, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase were significantly lower in current smokers than in non-current smokers. However, no meaningful differences in the proportions of six periodontal pathogens were observed between current and non-current smokers.
Smoking exerted the greatest influence on periodontitis risk among lifestyle factors. Smoking may suppress the host-defense system, which may promote periodontal disease progression. |
---|---|
AbstractList | Insufficient data exist regarding the long-term influence of lifestyle factors including smoking on periodontal health. The objective of this study was to examine the prospective association between smoking and periodontal disease progression and the effects of smoking on salivary biomarkers related to periodontitis.
Probing depth (PD) was measured at health checkups of workers in 1999 and 2003; additionally, lifestyle information was obtained through a questionnaire. In 2003, 219 of 256 (86%) workers examined at baseline completed PD measurements; saliva samples were also collected. Change in PD was used for assessment of periodontitis progression when three or more sites displayed an increase of >or=2 mm over 4 years. Salivary biomarker levels were determined by real-time polymerase chain reaction and enzyme assay. Statistical methods included bivariate and multivariate regression analyses.
In the multiple logistic model, in which lifestyle-related factors served as independent variables, significant variables were current smoking and hours of sleep; respective odds ratios were 2.3 and 2.1. Additionally, 38.5% of periodontal disease progression was attributable to current smoking. Moreover, pack-years of smoking showed a dose-response relationship with disease progression. Levels of salivary markers including prostaglandin E(2), lactoferrin, albumin, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase were significantly lower in current smokers than in non-current smokers. However, no meaningful differences in the proportions of six periodontal pathogens were observed between current and non-current smokers.
Smoking exerted the greatest influence on periodontitis risk among lifestyle factors. Smoking may suppress the host-defense system, which may promote periodontal disease progression. |
Author | Nagata, Hideki Kuboniwa, Masae Tanaka, Muneo Kataoka, Kosuke Nishida, Nobuko Shizukuishi, Satoshi Kibayashi, Miyuki Nakayama, Kunio Morimoto, Kanehisa |
Author_xml | – sequence: 1 givenname: Miyuki surname: Kibayashi fullname: Kibayashi, Miyuki organization: Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan – sequence: 2 givenname: Muneo surname: Tanaka fullname: Tanaka, Muneo – sequence: 3 givenname: Nobuko surname: Nishida fullname: Nishida, Nobuko – sequence: 4 givenname: Masae surname: Kuboniwa fullname: Kuboniwa, Masae – sequence: 5 givenname: Kosuke surname: Kataoka fullname: Kataoka, Kosuke – sequence: 6 givenname: Hideki surname: Nagata fullname: Nagata, Hideki – sequence: 7 givenname: Kunio surname: Nakayama fullname: Nakayama, Kunio – sequence: 8 givenname: Kanehisa surname: Morimoto fullname: Morimoto, Kanehisa – sequence: 9 givenname: Satoshi surname: Shizukuishi fullname: Shizukuishi, Satoshi |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17470019$$D View this record in MEDLINE/PubMed |
BookMark | eNpVUD1PwzAU9FBES2FmQ_4DKc9O4tQjqviSKrHAXD3Hz8VtakexC-rCbycSMDDdnU53Ot0Fm4QYiLFrAQuhQd7uYr-QAM0CFEgtJ2wGIGVRVlpO2UVKu1GKqoRzNhVN1QAIPWNf6xi2Ph-tD9jxNJITj47nd-KYUmw9Zh8DN5Q_iQJPh7j3YTt6HHlPg482huyzT3zwac8xWJ6w8x84nLjx8YDDnobRpA4zWZ7j_9QlO3PYJbr6xTl7e7h_XT0V65fH59XdumirstFFU1boXOuMsWWtHNWWZFvRUjVCLlEtNbTYgq3BCD1yAmVNXUrnrFSoWpJzdvPT2x_NgeymH_w47bT5O0J-A-_RZHM |
CitedBy_id | crossref_primary_10_1016_j_pdpdt_2017_01_183 crossref_primary_10_2334_josnusd_55_245 crossref_primary_10_1111_j_1600_0765_2011_01370_x crossref_primary_10_1111_odi_13847 crossref_primary_10_1016_j_mehy_2009_06_017 crossref_primary_10_1155_2014_593151 crossref_primary_10_1007_s11845_022_02940_z crossref_primary_10_1111_prd_12449 crossref_primary_10_1111_jre_12537 crossref_primary_10_1111_j_1601_0825_2011_01891_x crossref_primary_10_3390_biology10050441 crossref_primary_10_1111_j_1600_0765_2010_01290_x crossref_primary_10_1016_S0761_8425_09_73533_8 crossref_primary_10_1902_jop_2010_090630 crossref_primary_10_2174_1871526518666181005120804 crossref_primary_10_1016_j_adaj_2018_12_004 crossref_primary_10_1016_j_anaerobe_2008_12_005 crossref_primary_10_1016_j_archoralbio_2012_05_004 crossref_primary_10_1111_j_1600_0765_2012_01479_x crossref_primary_10_1016_j_jebdp_2018_02_003 crossref_primary_10_1080_08916934_2018_1527907 crossref_primary_10_1111_clr_14147 crossref_primary_10_1111_j_1600_051X_2010_01563_x crossref_primary_10_3390_healthcare11010132 crossref_primary_10_5005_jp_journals_10015_1381 crossref_primary_10_1016_j_mehy_2010_10_009 crossref_primary_10_2298_SGS0802107R crossref_primary_10_4103_jomfp_JOMFP_317_18 crossref_primary_10_1002_cre2_609 crossref_primary_10_3390_ijerph16224433 crossref_primary_10_4103_jiaphd_jiaphd_13_21 crossref_primary_10_1007_s40496_017_0158_7 crossref_primary_10_1186_1746_160X_10_39 crossref_primary_10_1111_j_1600_0765_2011_01375_x crossref_primary_10_1002_JPER_22_0241 crossref_primary_10_1016_j_archoralbio_2007_11_002 crossref_primary_10_4103_jfmpc_jfmpc_937_19 crossref_primary_10_1111_j_1600_051X_2009_01508_x crossref_primary_10_1111_j_1600_051X_2009_01480_x crossref_primary_10_1177_0022034509356045 crossref_primary_10_1007_s40496_018_0170_6 crossref_primary_10_1155_2018_4184190 crossref_primary_10_1111_j_1600_0765_2008_01194_x crossref_primary_10_1111_j_1600_0757_2009_00315_x crossref_primary_10_7759_cureus_17474 crossref_primary_10_5051_jpis_2016_46_1_10 crossref_primary_10_1111_idh_12124 crossref_primary_10_1016_j_jdent_2007_09_007 crossref_primary_10_1111_prd_12063 crossref_primary_10_1155_2021_1982083 crossref_primary_10_3390_ijms21207477 crossref_primary_10_1111_prd_12117 crossref_primary_10_1111_eje_12136 crossref_primary_10_1111_jicd_12017 crossref_primary_10_1016_j_heliyon_2023_e17093 crossref_primary_10_1016_j_amepre_2018_02_014 crossref_primary_10_4103_jpbs_jpbs_516_22 crossref_primary_10_3389_froh_2022_1003679 crossref_primary_10_1186_s12903_016_0216_x crossref_primary_10_1902_jop_2008_080149 crossref_primary_10_7717_peerj_8441 crossref_primary_10_1002_JPER_18_0545 crossref_primary_10_1590_1807_3107BOR_2016_vol30_0092 crossref_primary_10_1902_jop_2014_140319 crossref_primary_10_1186_1471_2121_9_19 crossref_primary_10_1111_j_1600_0757_2011_00425_x crossref_primary_10_1111_j_1600_0765_2008_01120_x crossref_primary_10_1016_j_archoralbio_2021_105184 crossref_primary_10_1177_0748233718817192 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1902/jop.2007.060292 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Dentistry |
ExternalDocumentID | 17470019 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Japan |
GeographicLocations_xml | – name: Japan |
GroupedDBID | --- -Y1 .55 0R~ 1OB 1OC 33P 34H 53G 5GY 5RE AAEUS AANLZ AAQQT AASGY AAWTL AAXRX AAZKR ABCUV ABDQB ABJNI ABLJU ABOCM ABQWH ABXGK ACAHQ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACXBN ACXQS ADBBV ADBTR ADEOM ADKYN ADMGS ADOZA ADXAS ADZMN AEIGN AENEX AEUYR AFFNX AFFPM AFGKR AFPWT AHBTC AIACR AITYG AIURR ALMA_UNASSIGNED_HOLDINGS ALUQN AMYDB BFHJK C45 CGR CS3 CUY CVF CWXXS DCZOG DRFUL DRMAN DRSTM DU5 EBS ECM EIF EJD F5P FUBAC GK1 HGLYW I4R KBYEO L7B LATKE LEEKS LUTES LYRES MEWTI MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM NPM O9- OVD P2P P2W PER RJQFR ROL SAMSI SJN SUPJJ TEORI UCV UMD USG W99 WH7 WOHZO WXSBR X7M XZL YOJ ZE2 ZGI ZVN ZZTAW |
ID | FETCH-LOGICAL-c4379-734affcfbbd356fe5de2c4e867128a6890cac0d50b1990ce06db532ffd26a6ce2 |
ISSN | 0022-3492 |
IngestDate | Sat Sep 28 07:45:42 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c4379-734affcfbbd356fe5de2c4e867128a6890cac0d50b1990ce06db532ffd26a6ce2 |
PMID | 17470019 |
ParticipantIDs | pubmed_primary_17470019 |
PublicationCentury | 2000 |
PublicationDate | May 2007 |
PublicationDateYYYYMMDD | 2007-05-01 |
PublicationDate_xml | – month: 05 year: 2007 text: May 2007 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Journal of periodontology (1970) |
PublicationTitleAlternate | J Periodontol |
PublicationYear | 2007 |
SSID | ssj0021430 |
Score | 2.2171102 |
Snippet | Insufficient data exist regarding the long-term influence of lifestyle factors including smoking on periodontal health. The objective of this study was to... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 859 |
SubjectTerms | Adolescent Adult Albumins - metabolism Alkaline Phosphatase - metabolism Aspartate Aminotransferases - metabolism Bacteroidaceae - isolation & purification Biomarkers - metabolism Dental Health Surveys Dinoprostone - metabolism Disease Progression Female Humans Japan L-Lactate Dehydrogenase - metabolism Lactoferrin - metabolism Life Style Logistic Models Longitudinal Studies Male Middle Aged Periodontitis - etiology Periodontitis - metabolism Periodontitis - microbiology Population Surveillance Regression Analysis Risk Factors Saliva - metabolism Sex Factors Smoking - adverse effects Smoking - metabolism |
Title | Longitudinal study of the association between smoking as a periodontitis risk and salivary biomarkers related to periodontitis |
URI | https://www.ncbi.nlm.nih.gov/pubmed/17470019 |
Volume | 78 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELa25QAXVJ6lPOQDtyoQsokTH1ELqijtqZV6q_wUy6rJqtkILYf-J_4hM7Y3cRYqHhcrimMr8XyajMcz3xDyWlbGYKxFkvMqh0awRL7DMDHFS8WMAJljvvPJKTs6zz9dFBeTyY8oaqlbyjfq-2_zSv5HqnAP5IpZsv8g2X5SuAHXIF9oQcLQ_pWMPzdYbajTrrJVu6aHRlNSDKveh2K1V83cpSS2-wLpimewI3WMqq0PMHcudIFHQ9erfUzLx8id69anu4BdClbqaNQtdm3_jGd3QiIoXqaRx-F4JsUKazj5sP1VN58N_oNazJ05e9LVpokOTb7MtPDnTLKb9x3HnQSd9M2PEK0wIydGOYQMxkkFOR8p5rKKAFhEWrbyJOK_aH_u2GS_NotATcnSzM8YYWFx5cAAGzE8ced_7t2g4153bZGtskKVeoruobDDB-Mz7enp4WsClxS819uNt0Ky2jDTxobGGTZnO-R-kBx97-H1gExM_ZDcPcQoMiwE-IjcxDCjDma0sRRgRiOY0QAzGmAGfVTQEWAowowCzOgaZnSAGQ0wo8tmPOoxOf_44ezgKAllOxKF5JZJOc2FtcpKqacFs6bQJlO5QSLFrBKs4qkSKtVFCkoBrk3KtCymmbU6YwIL1D0h23VTm11CGWeZTgur80zkhpVCgsIRhsNPRVtVsGfkqV-6y4XnZrlcL-rerT3Pyb0BgS_IHQvKwLwEy3IpXzlp_gTIoH73 |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Longitudinal+study+of+the+association+between+smoking+as+a+periodontitis+risk+and+salivary+biomarkers+related+to+periodontitis&rft.jtitle=Journal+of+periodontology+%281970%29&rft.au=Kibayashi%2C+Miyuki&rft.au=Tanaka%2C+Muneo&rft.au=Nishida%2C+Nobuko&rft.au=Kuboniwa%2C+Masae&rft.date=2007-05-01&rft.issn=0022-3492&rft.volume=78&rft.issue=5&rft.spage=859&rft_id=info:doi/10.1902%2Fjop.2007.060292&rft_id=info%3Apmid%2F17470019&rft_id=info%3Apmid%2F17470019&rft.externalDocID=17470019 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3492&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3492&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3492&client=summon |