Polymyxin B: pharmacokinetics of single doses given intravenously and intramuscularly to turkeys, and minimal inhibitory concentrations for Escherichia coli and Pasteurella multocida

• Published in: Zentralblatt für Veterinärmedizin. Reihe B Vol. 39; no. 9; p. 649
• Main Authors: Freidlin, P J, Hoexter, S, Bock, R, Ziv, G, Samberg, Y, Risenberg, R, Inbar, A
• Format: Journal Article
• Language: English
• Published: Germany 01.11.1992
• Subjects: Animals; Escherichia coli - drug effects; Injections, Intramuscular - veterinary; Injections, Intravenous - veterinary; Pasteurella multocida - drug effects; Polymyxin B - administration & dosage; Polymyxin B - pharmacokinetics; Polymyxin B - pharmacology; Turkeys - metabolism

The 50% and 90% minimal inhibitory concentrations (MIC50 and MIC90) of polymyxin B for avian Escherichia coli and Pasteurella multocida isolates were determined by the agar plate dilution method. Polymyxin B at approximate MIC level in serum was bactericidal for E. coli in 2 to 4 hours. Aqueous poly...