Cross sectional study reveals a high percentage of asymptomatic Plasmodium vivax infection in the Amazon Rio Negro Area, Brazil

A parasitological, clinical, serological and molecular cross-sectional study carried out in a highly endemic malaria area of Rio Negro in the Amazon State, Brazil, revealed a high prevalence of asymptomatic Plasmodium vivax infection. A total of 109 persons from 25 families were studied in five vill...

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Published inRevista do Instituto de Medicina Tropical de São Paulo Vol. 49; no. 3; pp. 159 - 164
Main Authors SUAREZ-MUTIS, Martha C, CUERVO, Patricia, LEORATTI, Fabiana M. S, MORAES-AVILA, Sandra L, FERREIRA, Antonio Walter, FERNANDES, Octavio, COURA, José Rodrigues
Format Journal Article
LanguageEnglish
Published São Paulo Instituto de Medicina Tropical de São Paulo 01.06.2007
Instituto de Medicina Tropical de Sao Paulo
Instituto de Medicina Tropical
Subjects
Adolescent
Adult
Aged
Animals
Antibodies, Protozoan - blood
Biological and medical sciences
Brazil - epidemiology
Child
Child, Preschool
Cross-Sectional Studies
DNA, Protozoan - analysis
Enzyme-Linked Immunosorbent Assay
Female
General aspects
Human protozoal diseases
Humans
Infectious diseases
Malaria
Malaria, Vivax - diagnosis
Malaria, Vivax - epidemiology
Male
Medical sciences
Middle Aged
Parasitic diseases
Plasmodium vivax - genetics
Plasmodium vivax - immunology
Polymerase Chain Reaction
Prevalence
Protozoal diseases
TROPICAL MEDICINE
South America
Brazil
America
Infection
Protozoa
Plasmodium vivax
Apicomplexa
Protozoal disease
Malaria
Cross sectional study
Brazilian Amazon
Tropical medicine
Asymptomatic infection
Asymptomatic
Parasitosis
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Abstract A parasitological, clinical, serological and molecular cross-sectional study carried out in a highly endemic malaria area of Rio Negro in the Amazon State, Brazil, revealed a high prevalence of asymptomatic Plasmodium vivax infection. A total of 109 persons from 25 families were studied in five villages. Ninety-nine inhabitants (90.8%) had at least one previous episode of malaria. Serology showed 85.7% and 46.9% of positivity when P. falciparum antigens and P. vivax MSP-1, respectively, were used. Twenty blood samples were PCR positive for P. vivax (20.4%) and no P. falciparum infection was evidenced by this technique. No individual presenting positive PCR reaction had clinical malaria during the survey neither in the six months before nor after, confirming that they were cases of asymptomatic infection. Only one 12 year old girl presented a positive thick blood smear for P. vivax. This is the first description of asymptomatic Plasmodium infection in this area studied.
AbstractList A parasitological, clinical, serological and molecular cross-sectional study carried out in a highly endemic malaria area of Rio Negro in the Amazon State, Brazil, revealed a high prevalence of asymptomatic Plasmodium vivax infection. A total of 109 persons from 25 families were studied in five villages. Ninety-nine inhabitants (90.8%) had at least one previous episode of malaria. Serology showed 85.7% and 46.9% of positivity when P. falciparum antigens and P. vivax MSP-1, respectively, were used. Twenty blood samples were PCR positive for P. vivax (20.4%) and no P. falciparum infection was evidenced by this technique. No individual presenting positive PCR reaction had clinical malaria during the survey neither in the six months before nor after, confirming that they were cases of asymptomatic infection. Only one 12 year old girl presented a positive thick blood smear for P. vivax. This is the first description of asymptomatic Plasmodium infection in this area studied. Um estudo seccional parasitológico, clínico, sorológico e molecular, realizado em uma área altamente endêmica para malária, no Rio Negro, Estado do Amazonas, revela alta prevalência de infecção assintomática por Plasmodium vivax. Um total de 109 pessoas de 25 famílias residentes em cinco comunidades do Rio Padauiri, afluente do Rio Negro, foram estudadas. Noventa por cento dos habitantes (90,8%) tinham tido pelo menos um episodio prévio de malária. A sorologia mostrou 85,7% e 46,9% de positividade quando antígenos de P. falciparum e P. vivax MSP-1, foram respectivamente usados. Vinte amostras de sangue submetidas ao PCR foram positivas para P. vivax (20,4%), entretanto, nenhuma foi positiva para o P. falciparum por esta técnica. Nenhum paciente com PCR positivo durante o inquérito e seis meses antes ou depois teve manifestações clínicas de malária, portanto, podemos afirmar que eram assintomáticos. Somente uma criança de 12 anos de idade teve gota espessa positiva para P. vivax. Esta é a primeira descrição de infecção assintomática por Plasmodium na área estudada.
A parasitological, clinical, serological and molecular cross-sectional study carried out in a highly endemic malaria area of Rio Negro in the Amazon State, Brazil, revealed a high prevalence of asymptomatic Plasmodium vivax infection. A total of 109 persons from 25 families were studied in five villages. Ninety-nine inhabitants (90.8%) had at least one previous episode of malaria. Serology showed 85.7% and 46.9% of positivity when P. falciparum antigens and P. vivax MSP-1, respectively, were used. Twenty blood samples were PCR positive for P. vivax (20.4%) and no P. falciparum infection was evidenced by this technique. No individual presenting positive PCR reaction had clinical malaria during the survey neither in the six months before nor after, confirming that they were cases of asymptomatic infection. Only one 12 year old girl presented a positive thick blood smear for P. vivax. This is the first description of asymptomatic Plasmodium infection in this area studied.
Author COURA, José Rodrigues
CUERVO, Patricia
LEORATTI, Fabiana M. S
MORAES-AVILA, Sandra L
FERREIRA, Antonio Walter
FERNANDES, Octavio
SUAREZ-MUTIS, Martha C
AuthorAffiliation Universidade de São Paulo
Instituto Oswaldo Cruz
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  organization: Laboratôrio de Doenças Parasitarias, Departarnento de Medicina Tropical, Instituto Oswaldo Cruz, FlOCRUZ. Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil
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  givenname: Patricia
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  fullname: CUERVO, Patricia
  organization: Laboratôrio de Doenças Parasitarias, Departarnento de Medicina Tropical, Instituto Oswaldo Cruz, FlOCRUZ. Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil
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  givenname: Fabiana M. S
  surname: LEORATTI
  fullname: LEORATTI, Fabiana M. S
  organization: Instituto de Medicina Tropical. Universidade de São Paulo (1MT-SP). Av. Dr. Enéas de Carvalho Aguiar 470, 05403-000 São Paulo, SP, Brazil
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  givenname: Sandra L
  surname: MORAES-AVILA
  fullname: MORAES-AVILA, Sandra L
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  givenname: Antonio Walter
  surname: FERREIRA
  fullname: FERREIRA, Antonio Walter
  organization: Instituto de Medicina Tropical. Universidade de São Paulo (1MT-SP). Av. Dr. Enéas de Carvalho Aguiar 470, 05403-000 São Paulo, SP, Brazil
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  givenname: Octavio
  surname: FERNANDES
  fullname: FERNANDES, Octavio
  organization: Laboratôrio de Doenças Parasitarias, Departarnento de Medicina Tropical, Instituto Oswaldo Cruz, FlOCRUZ. Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil
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  givenname: José Rodrigues
  surname: COURA
  fullname: COURA, José Rodrigues
  organization: Laboratôrio de Doenças Parasitarias, Departarnento de Medicina Tropical, Instituto Oswaldo Cruz, FlOCRUZ. Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil
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DocumentTitleAlternate Estudo seccional revela um alto percentual de infecção assintomática por Plasmodium vivax em área do Rio Negro, Amazonas, Brasil
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Issue 3
Keywords Infection
Protozoa
Plasmodium vivax
Apicomplexa
Protozoal disease
Malaria
Cross sectional study
Brazilian Amazon
Tropical medicine
Asymptomatic infection
Asymptomatic
Parasitosis
Language English
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Snippet A parasitological, clinical, serological and molecular cross-sectional study carried out in a highly endemic malaria area of Rio Negro in the Amazon State,...
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SubjectTerms Adolescent
Adult
Aged
Animals
Antibodies, Protozoan - blood
Biological and medical sciences
Brazil - epidemiology
Child
Child, Preschool
Cross-Sectional Studies
DNA, Protozoan - analysis
Enzyme-Linked Immunosorbent Assay
Female
General aspects
Human protozoal diseases
Humans
Infectious diseases
Malaria
Malaria, Vivax - diagnosis
Malaria, Vivax - epidemiology
Male
Medical sciences
Middle Aged
Parasitic diseases
Plasmodium vivax - genetics
Plasmodium vivax - immunology
Polymerase Chain Reaction
Prevalence
Protozoal diseases
TROPICAL MEDICINE
Title Cross sectional study reveals a high percentage of asymptomatic Plasmodium vivax infection in the Amazon Rio Negro Area, Brazil
URI https://www.ncbi.nlm.nih.gov/pubmed/17625693
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Volume 49
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