Dysregulation of immune response following neurosurgical operations
Background: Postoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function has been described after central nervous system surgery and in patients harboring malignant brain tumors. The aim of our study was to investi...
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| Published in | Acta anaesthesiologica Scandinavica Vol. 44; no. 1; pp. 82 - 87 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Copenhagen
Munksgaard International Publishers
01.01.2000
Blackwell |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background: Postoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function has been described after central nervous system surgery and in patients harboring malignant brain tumors. The aim of our study was to investigate whether differences in cell‐mediated immunity can be found in patients undergoing craniotomy for surgery of glioblastoma or clipping of an intracerebral aneurysm.
Methods: In order to determine the influence of the underlying disease on the immune system, we measured changes in cytokine concentrations (IL‐6, IL‐10, TGF‐beta1) and lymphocyte‐subsets (CD3+, CD3+HLA‐DR+, CD4+, CD8+, CD19+, and CD16+56+) in 8 patients with glioblastoma and in 8 patients with an intracerebral aneurysm before, during and after the neurosurgical procedure.
Results: In the comparison of glioblastoma and aneurysm patients, we could show that IL‐6 plasma levels were pre‐ and intraoperatively higher in the aneurysm‐group (P<0.05), and the plasma concentrations of IL‐10 and TGF‐β were significantly elevated in the glioma‐group. The lymphocyte‐subsets showed a significantly lower percentage of NK‐cells and activated T‐cells in the glioma‐group.
Conclusion: Our results document a significant dysregulation of immune response in glioma patients. This may be induced by elevated plasma concentrations of immunoinhibiting cytokines IL‐10 and transforming growth factor‐beta 1. |
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| AbstractList | Background:
Postoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function has been described after central nervous system surgery and in patients harboring malignant brain tumors. The aim of our study was to investigate whether differences in cell‐mediated immunity can be found in patients undergoing craniotomy for surgery of glioblastoma or clipping of an intracerebral aneurysm.
Methods:
In order to determine the influence of the underlying disease on the immune system, we measured changes in cytokine concentrations (IL‐6, IL‐10, TGF‐beta1) and lymphocyte‐subsets (CD3+, CD3+HLA‐DR+, CD4+, CD8+, CD19+, and CD16+56+) in 8 patients with glioblastoma and in 8 patients with an intracerebral aneurysm before, during and after the neurosurgical procedure.
Results:
In the comparison of glioblastoma and aneurysm patients, we could show that IL‐6 plasma levels were pre‐ and intraoperatively higher in the aneurysm‐group (
P
<0.05), and the plasma concentrations of IL‐10 and TGF‐β were significantly elevated in the glioma‐group. The lymphocyte‐subsets showed a significantly lower percentage of NK‐cells and activated T‐cells in the glioma‐group.
Conclusion:
Our results document a significant dysregulation of immune response in glioma patients. This may be induced by elevated plasma concentrations of immunoinhibiting cytokines IL‐10 and transforming growth factor‐beta 1. BACKGROUNDPostoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function has been described after central nervous system surgery and in patients harboring malignant brain tumors. The aim of our study was to investigate whether differences in cell-mediated immunity can be found in patients undergoing craniotomy for surgery of glioblastoma or clipping of an intracerebral aneurysm. METHODSIn order to determine the influence of the underlying disease on the immune system, we measured changes in cytokine concentrations (IL-6, IL-10, TGF-beta1) and lymphocyte-subsets (CD3+, CD3+HLA-DR+, CD4+, CD8+, CD19+, and CD16+56+) in 8 patients with glioblastoma and in 8 patients with an intracerebral aneurysm before, during and after the neurosurgical procedure. RESULTSIn the comparison of glioblastoma and aneurysm patients, we could show that IL-6 plasma levels were pre- and intraoperatively higher in the aneurysm-group (P<0.05), and the plasma concentrations of IL-10 and TGF-beta were significantly elevated in the glioma-group. The lymphocyte-subsets showed a significantly lower percentage of NK-cells and activated T-cells in the glioma-group. CONCLUSIONOur results document a significant dysregulation of immune response in glioma patients. This may be induced by elevated plasma concentrations of immunoinhibiting cytokines IL-10 and transforming growth factor-beta 1. Postoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function has been described after central nervous system surgery and in patients harboring malignant brain tumors. The aim of our study was to investigate whether differences in cell-mediated immunity can be found in patients undergoing craniotomy for surgery of glioblastoma or clipping of an intracerebral aneurysm. In order to determine the influence of the underlying disease on the immune system, we measured changes in cytokine concentrations (IL-6, IL-10, TGF-beta1) and lymphocyte-subsets (CD3+, CD3+HLA-DR+, CD4+, CD8+, CD19+, and CD16+56+) in 8 patients with glioblastoma and in 8 patients with an intracerebral aneurysm before, during and after the neurosurgical procedure. In the comparison of glioblastoma and aneurysm patients, we could show that IL-6 plasma levels were pre- and intraoperatively higher in the aneurysm-group (P<0.05), and the plasma concentrations of IL-10 and TGF-beta were significantly elevated in the glioma-group. The lymphocyte-subsets showed a significantly lower percentage of NK-cells and activated T-cells in the glioma-group. Our results document a significant dysregulation of immune response in glioma patients. This may be induced by elevated plasma concentrations of immunoinhibiting cytokines IL-10 and transforming growth factor-beta 1. Background: Postoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function has been described after central nervous system surgery and in patients harboring malignant brain tumors. The aim of our study was to investigate whether differences in cell‐mediated immunity can be found in patients undergoing craniotomy for surgery of glioblastoma or clipping of an intracerebral aneurysm. Methods: In order to determine the influence of the underlying disease on the immune system, we measured changes in cytokine concentrations (IL‐6, IL‐10, TGF‐beta1) and lymphocyte‐subsets (CD3+, CD3+HLA‐DR+, CD4+, CD8+, CD19+, and CD16+56+) in 8 patients with glioblastoma and in 8 patients with an intracerebral aneurysm before, during and after the neurosurgical procedure. Results: In the comparison of glioblastoma and aneurysm patients, we could show that IL‐6 plasma levels were pre‐ and intraoperatively higher in the aneurysm‐group (P<0.05), and the plasma concentrations of IL‐10 and TGF‐β were significantly elevated in the glioma‐group. The lymphocyte‐subsets showed a significantly lower percentage of NK‐cells and activated T‐cells in the glioma‐group. Conclusion: Our results document a significant dysregulation of immune response in glioma patients. This may be induced by elevated plasma concentrations of immunoinhibiting cytokines IL‐10 and transforming growth factor‐beta 1. |
| Author | Giesselmann, H. Mühling, J. Nopens, H. Hempelmann, G. Dehne, M. G. Ebel, H. Sablotzki, A. |
| Author_xml | – sequence: 1 givenname: A. surname: Sablotzki fullname: Sablotzki, A. organization: Department of Anaesthesiology and Intensive Care Medicine, and Department of Neurosurgery, Justus-Liebig-University, Giessen, Germany – sequence: 2 givenname: H. surname: Ebel fullname: Ebel, H. organization: Department of Anaesthesiology and Intensive Care Medicine, and Department of Neurosurgery, Justus-Liebig-University, Giessen, Germany – sequence: 3 givenname: J. surname: Mühling fullname: Mühling, J. organization: Department of Anaesthesiology and Intensive Care Medicine, and Department of Neurosurgery, Justus-Liebig-University, Giessen, Germany – sequence: 4 givenname: M. G. surname: Dehne fullname: Dehne, M. G. organization: Department of Anaesthesiology and Intensive Care Medicine, and Department of Neurosurgery, Justus-Liebig-University, Giessen, Germany – sequence: 5 givenname: H. surname: Nopens fullname: Nopens, H. organization: Department of Anaesthesiology and Intensive Care Medicine, and Department of Neurosurgery, Justus-Liebig-University, Giessen, Germany – sequence: 6 givenname: H. surname: Giesselmann fullname: Giesselmann, H. organization: Department of Anaesthesiology and Intensive Care Medicine, and Department of Neurosurgery, Justus-Liebig-University, Giessen, Germany – sequence: 7 givenname: G. surname: Hempelmann fullname: Hempelmann, G. organization: Department of Anaesthesiology and Intensive Care Medicine, and Department of Neurosurgery, Justus-Liebig-University, Giessen, Germany |
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| Keywords | Human Intracranial Nervous system diseases Aneurysm Cytokine Glioblastoma Cardiovascular disease Cellular immunity Malignant tumor Artery Cerebral disorder Arterial disease Vascular disease Malignant glioma Immunosuppression Surgery Central nervous system disease Complication Lymphocyte Cerebrovascular disease |
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| Snippet | Background: Postoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function... Postoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function has been... Background: Postoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function... BACKGROUNDPostoperative infections are common and potentially fatal complications in neurosurgical intensive care medicine. An impairment of immune function... |
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| SubjectTerms | aneurysm Biological and medical sciences Brain Neoplasms - blood Brain Neoplasms - surgery Craniotomy Female glioblastoma Glioblastoma - blood Glioblastoma - surgery Humans immune dysregulation Immunity, Cellular - physiology interleukins Interleukins - blood Intracranial Aneurysm - blood Intracranial Aneurysm - surgery Lymphocyte Count Lymphocyte Subsets Male Medical sciences Middle Aged Neurosurgery Postoperative Complications - blood Postoperative Complications - immunology Skull, brain, vascular surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transforming Growth Factor beta - blood transforming growth factor-beta |
| Title | Dysregulation of immune response following neurosurgical operations |
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