Involvement of eNAMPT/TLR4 inflammatory signaling in progression of non‐alcoholic fatty liver disease, steatohepatitis, and fibrosis

• Published in: The FASEB journal Vol. 37; no. 3; pp. e22825 - n/a
• Main Authors: Sun, Belinda L., Sun, Xiaoguang, Kempf, Carrie L., Song, Jin H., Casanova, Nancy G., Camp, Sara M., Reyes Hernon, Vivian, Fallon, Michael, Bime, Christian, Martin, Diego R., Travelli, Cristina, Zhang, Donna D., Garcia, Joe G. N.
• Format: Journal Article
• Language: English
• Published: United States 01.03.2023
• Subjects: Animals; damage‐associated molecular pattern protein; extracellular nicotinamide phosphoribosyltransferase; Humans; Interleukin-6 - metabolism; Liver - metabolism; Liver Cirrhosis - metabolism; Mice; Non-alcoholic Fatty Liver Disease - metabolism; non‐alcoholic fatty liver disease; non‐alcoholic steatohepatitis; Toll-Like Receptor 4 - metabolism; toll‐like receptor 4; extracellular nicotinamide phosphoribosyltransferase; non-alcoholic fatty liver disease; damage-associated molecular pattern protein; toll-like receptor 4; non-alcoholic steatohepatitis
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fj.202201972RR

Although the progression of non‐alcoholic fatty liver disease (NAFLD) from steatosis to steatohepatitis (NASH) and cirrhosis remains poorly understood, a critical role for dysregulated innate immunity has emerged. We examined the utility of ALT‐100, a monoclonal antibody (mAb), in reducing NAFLD sev...