Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma

• Published in: Cell death and differentiation Vol. 23; no. 4; pp. 640 - 653
• Main Authors: Renner, G, Janouskova, H, Noulet, F, Koenig, V, Guerin, E, Bär, S, Nuesch, J, Rechenmacher, F, Neubauer, S, Kessler, H, Blandin, A-F, Choulier, L, Etienne-Selloum, N, Lehmann, M, Lelong-Rebel, I, Martin, S, Dontenwill, M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2016; Nature Publishing Group
• Subjects: 13; 13/2; 13/95; 631/67/581; 96; Apoptosis; Apoptosis - genetics; Astrocytes - metabolism; Astrocytes - pathology; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell Line, Tumor; Glioma - genetics; Glioma - metabolism; Glioma - pathology; Humans; Inhibitor of Apoptosis Proteins - genetics; Inhibitor of Apoptosis Proteins - metabolism; Integrin alpha5beta1 - genetics; Integrin alpha5beta1 - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Life Sciences; Original Paper; Phosphoproteins - genetics; Phosphoproteins - metabolism; Signal Transduction; Stem Cells; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism

Integrin α 5 β 1 expression is correlated with a worse prognosis in high-grade glioma. We previously unraveled a negative crosstalk between integrin α 5 β 1 and p53 pathway, which was proposed to be part of the resistance of glioblastoma to chemotherapies. The restoration of p53 tumor-suppressor fun...