Hepatitis C virus (HCV) in cryoglobulinaemic leukocytoclastic vasculitis (LCV): could the presence of HCV in skin lesions be related to T CD8+ lymphocytes, HLA-DR and ICAM-1 expression?

• Published in: Experimental dermatology Vol. 8; no. 6; pp. 480 - 486
• Main Authors: Bernacchi, E., Civita, L. L., Caproni, M., Zignego, A. L., Bianchi, B., Monti, M., Fabbri, P., Pasero, G., Ferri, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.1999; Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; CD8; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; Cryoglobulinemia - immunology; Cryoglobulinemia - pathology; Cryoglobulinemia - virology; Female; Fluorescent Antibody Technique, Direct; Hepacivirus - isolation & purification; Hepacivirus - pathogenicity; hepatitis C Virus; HLA-DR Antigens - metabolism; Humans; Immunohistochemistry; intercellular adhesion molecule-(ICAM-1); Intercellular Adhesion Molecule-1 - metabolism; Medical sciences; Middle Aged; Mixed cryoglobulinaemia; Purpura - immunology; Purpura - pathology; Purpura - virology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Vasculitis - immunology; Vasculitis - pathology; Vasculitis - virology; Virus; Human; Immunohistochemistry; Pathology; Immunopathology; Cryoglobulinemia; Leucocytoclastic vasculitis; Virological exploration; Flaviviridae; Molecular biology; Hepatitis C virus; Hepacivirus
• ISSN: 0906-6705; 1600-0625
• DOI: 10.1111/j.1600-0625.1999.tb00306.x

An association between mixed cryoglobulinaemia (MC) and hepatotropic viruses, chiefly hepatitis C virus (HCV), has been widely reported. The presence of HCV genomic sequences or HCV‐related viral proteins in the serum, purified cryoglobulins, peripheral blood mononuclear cells and into several tissu...