Ischemia-Reperfusion Injury is More Severe in Older Versus Young Rat Livers

• Published in: The Journal of surgical research Vol. 137; no. 1; pp. 96 - 102
• Main Authors: Park, Yeonho, M.D, Hirose, Ryutaro, M.D, Coatney, John L, Ferrell, Linda, M.D, Behrends, Matthias, M.D, Roberts, John P., M.D, Serkova, Natalie J., Ph.D, Niemann, Claus U., M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2007; Elsevier
• Subjects: age; Aging - physiology; Animals; Biological and medical sciences; Body Weight; General aspects; hepatocellular injury; Liver - pathology; Liver - physiopathology; Magnetic Resonance Spectroscopy; Male; Medical sciences; Neutrophils - enzymology; Neutrophils - pathology; Organ Size; Peroxidase - metabolism; rat liver; Rats; Rats, Inbred Lew; Reperfusion Injury - mortality; Reperfusion Injury - pathology; Reperfusion Injury - physiopathology; Severity of Illness Index; Surgery; Survival Rate; Temperature; warm ischemia reperfusion injury; warm ischemia reperfusion injury; age; hepatocellular injury; rat liver; Human; Rat; Liver; Rodentia; Cardiovascular disease; Trauma; Medicine; Vertebrata; Mammalia; Treatment; Ischemia; Animal; Surgery; Lesion; Severe; Elderly; Age; Comparative study

Background Hepatic warm ischemia during surgery remains a significant problem, particularly in organs with possible baseline dysfunction. The objective of this study was to investigate whether age influences the degree of warm ischemia-reperfusion injury in rat livers. Materials and methods The left...