Cytochrome-P4501A1 Mediates the Metabolism of 2,3,7,8-Tetrachlorodibenzofuran in the Rat and Human

• Published in: Toxicology and applied pharmacology Vol. 123; no. 1; pp. 34 - 42
• Main Authors: Tai, H.L., Mcreynolds, J.H., Goldstein, J.A., Eugster, H.P., Sengstag, C., Alworth, W.L., Olson, J.R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.1993
• Subjects: Animals; Benzofurans - metabolism; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System - physiology; Environmental Pollutants - metabolism; Humans; Liver - metabolism; Male; Oxidoreductases - physiology; Rats; Rats, Sprague-Dawley; Species Specificity

Previous studies have established that TCDF is rapidly metabolized and excreted in rats and that pretreatment of rats with TCDD increases the rate of hepatic metabolism of this compound. The extrahepatic metabolism of TCDF was investigated to assess which enzyme was involved in the metabolism of thi...