Role of Peroxisomes in Isoprenoid Biosynthesis

• Published in: The journal of histochemistry and cytochemistry Vol. 47; no. 9; pp. 1127 - 1132
• Main Authors: Aboushadi, Nahla, Engfelt, William Harrison, Paton, Vincent G, Krisans, Skaidrite K
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Histochemical Soc 01.09.1999; SAGE Publications
• Subjects: Acyl Coenzyme A - genetics; Acyl Coenzyme A - metabolism; Animals; Carbon-Carbon Double Bond Isomerases - genetics; Carbon-Carbon Double Bond Isomerases - metabolism; Cells, Cultured; CHO Cells; Cholesterol - metabolism; Cricetinae; Humans; Microbodies - enzymology; Microscopy, Fluorescence; Mutation; Protein Prenylation; Rats; Transfection; peroxisomes; cholesterol; isoprenoids; HMG-CoA reductase

Our group and others have recently demonstrated that peroxisomes contain a number of enzymes involved in cholesterol biosynthesis that previously were considered to be cytosolic or located in the endoplasmic reticulum (ER). Peroxisomes have been shown to contain HMG-CoA reductase, mevalonate kinase,...