Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

• Published in: Blood Vol. 113; no. 20; pp. 4922 - 4929
• Main Authors: Horton, Sarah J., Walf-Vorderwülbecke, Vanessa, Chatters, Steve J., Sebire, Neil J., de Boer, Jasper, Williams, Owen
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 14.05.2009; Americain Society of Hematology
• Subjects: Animals; Biological and medical sciences; Cell Transformation, Neoplastic - genetics; Cells, Cultured; Chromosome Aberrations; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - genetics; Gene Targeting - methods; Genetic Therapy; Hematologic and hematopoietic diseases; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors; Myeloid-Lymphoid Leukemia Protein - genetics; Oncogene Proteins, Fusion - antagonists & inhibitors; Oncogene Proteins, Fusion - genetics; Remission Induction; Survival Analysis; Transcription Factors - antagonists & inhibitors; Transcription Factors - genetics; Acute myelogenous leukemia; Hematology; Cure; C-Onc gene; Genetics; Malignant hemopathy; Onc gene; Protooncogene; Cancer

Chromosomal translocations involving 11q23 are frequent in infant acute leukemia and give rise to the formation of MLL fusion genes. The mechanism of leukemic transformation by these fusions has been the subject of numerous investigations. However, the dependence of acute leukemia on MLL fusion acti...