Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities - Horton, Sarah J.; Walf-Vorderwülbecke, Vanessa; Chatters, Steve J.; Sebire, Neil J.; de Boer, Jasper; Williams, Owen (Blood, 2009)
Keywords: Animals; Biological and medical sciences; Cell Transformation, Neoplastic - genetics; Cells, Cultured; Chromosome Aberrations; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - genetics; Gene Targeting - methods; Genetic Therapy; Hematologic and hematopoietic diseases; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors; Myeloid-Lymphoid Leukemia Protein - genetics; Oncogene Proteins, Fusion - antagonists & inhibitors; Oncogene Proteins, Fusion - genetics; Remission Induction; Survival Analysis; Transcription Factors - antagonists & inhibitors; Transcription Factors - genetics; Acute myelogenous leukemia; Hematology; Cure; C-Onc gene; Genetics; Malignant hemopathy; Onc gene; Protooncogene; Cancer