TGFβ Promotes Genomic Instability after Loss of RUNX3

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 1; pp. 88 - 102
• Main Authors: Krishnan, Vaidehi, Chong, Yu Lin, Tan, Tuan Zea, Kulkarni, Madhura, Bin Rahmat, Muhammad Bakhait, Tay, Lavina Sierra, Sankar, Haresh, Jokhun, Doorgesh S, Ganesan, Amudha, Chuang, Linda Shyue Huey, Voon, Dominic C, Shivashankar, G V, Thiery, Jean-Paul, Ito, Yoshiaki
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 01.01.2018
• Subjects: Antioxidants; Cancer; Cytokines; Deoxyribonucleic acid; DNA; DNA damage; Double-strand break repair; Drug resistance; Gene expression; Genomic instability; Heme; Heme oxygenase (decyclizing); Historical account; Inactivation; Inflammation; Invasiveness; Mesenchyme; Oxygenase; Phenotypes; Runx3 protein; Senescence; Transcription; Tumor suppressor genes; Tumors

Studies of genomic instability have historically focused on intrinsic mechanisms rather than extrinsic mechanisms based in the tumor microenvironment (TME). TGFβ is the most abundantly secreted cytokine in the TME, where it imparts various aggressive characteristics including invasive migration, dru...