The Bayesian Analysis of Population Pharmacokinetic Models

• Published in: Journal of the American Statistical Association Vol. 91; no. 433; pp. 62 - 75
• Main Author: Wakefield, Jon
• Format: Journal Article
• Language: English
• Published: Alexandria, VA Taylor & Francis Group 01.03.1996; American Statistical Association; Taylor & Francis Ltd
• Subjects: Algorithms; Applications and Case Studies; Bayesian analysis; Biological and medical sciences; Covariate selection; Dosage; Drug design; Drugs; General pharmacology; Glycoproteins; Hastings-Metropolis algorithm; Hierarchical models; Mallets; Markov chains; Mathematical models; Medical research; Medical sciences; Modeling; Parametric models; Pharmacokinetic models; Pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology; Pharmacology. Drug treatments; Statistical analysis; Statistical variance; Statistics; Bayes estimation; Pharmacokinetics; Statistical model

Pharmacokinetics is the study of the time course of a drug and its metabolites following its introduction into the body. Population pharmacokinetic studies are becoming increasingly important as an aid to drug development. The data from such studies typically consist of dose histories, drug concentr...