Control of Cell Proliferation by Progress in Differentiation: Clues to Mechanisms of Aging, Cancer Causation and Therapy

• Published in: Journal of theoretical biology Vol. 193; no. 4; pp. 663 - 678
• Main Authors: von Wagenheim, Karl-Hartmut, Peterson, Hans-Peter
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 21.08.1998
• Subjects: Aging - pathology; Animals; Cell Differentiation - drug effects; Cell Differentiation - physiology; Cell Differentiation - radiation effects; Cell Division - physiology; Cell Nucleus - physiology; Cell Transformation, Neoplastic - pathology; Cellular Senescence - physiology; Humans; Mitochondria - physiology; Neoplasms - therapy

In multicellular organisms, the control of cell proliferation occurs, in part, by modulating the progress in differentiation. In normal and neoplastic cells, for example, progress towards terminal differentiation concludes cell proliferation, whereas arrest of progress in differentiation causes unco...