Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway - Zhang, Yiqing; Liu, Xialu; Zheng, Zitong; Huang, Haiqiang; Wang, Yurou; Wu, Shuqin; Shu, Yuan; Yang, Yuxin; Zhong, Yufei; Liao, Pengfei; Wang, Yongsong; Pan, Zezheng (Scientific reports, 2025)
Keywords: 1-Phosphatidylinositol 3-kinase; 631/114; 631/154; 692/308; AKT protein; AKT1 protein; Animals; Butylene Glycols - chemistry; Butylene Glycols - pharmacology; Cyclophosphamide; Cyclophosphamide - pharmacology; Disease Models, Animal; Estrogens; Female; Glucosides - chemistry; Glucosides - pharmacology; Granulosa cells; Herbal medicine; Humanities and Social Sciences; Humans; Medicinal plants; Mice; Molecular Docking Simulation; Molecular dynamics; Molecular Dynamics Simulation; Molecular modelling; multidisciplinary; Network Pharmacology; Ovaries; Pharmacology; Phosphatidylinositol 3-Kinases - metabolism; PI3K/Akt pathway; Premature ovarian insufficiency; Primary Ovarian Insufficiency - drug therapy; Primary Ovarian Insufficiency - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Science; Science (multidisciplinary); Secoisolariciresinol diglucoside; Signal transduction; Signal Transduction - drug effects; Granulosa cells; Network pharmacology; PI3K/Akt pathway; Secoisolariciresinol diglucoside; Premature ovarian insufficiency