A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury
Traumatic brain injury (TBI) can lead to disability or devastating consequences with few established treatments. Although ferroptosis has been shown to be involved in TBI, the underlying mechanism was rarely known. Melatonin has been indicated to exhibit neuroprotective activities. However, the anti...
Saved in:
Published in | Free radical biology & medicine Vol. 178; pp. 271 - 294 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.01.2022
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Traumatic brain injury (TBI) can lead to disability or devastating consequences with few established treatments. Although ferroptosis has been shown to be involved in TBI, the underlying mechanism was rarely known. Melatonin has been indicated to exhibit neuroprotective activities. However, the anti-ferroptotic effects of melatonin on TBI have not yet to be elucidated. We aimed to investigate whether ferroptosis was induced in humans after TBI and whether ferroptosis inhibition by melatonin could protect against blood-brain barrier (BBB) damage after TBI in vivo and in vitro. Circular RNAs (circRNAs) are highly expressed in the brain. For the first time, differentially expressed circRNA after melatonin treatment for TBI were detected by RNA sequencing. We found that lipid peroxidation was induced in humans after TBI, while melatonin significantly improved brain function of mice after TBI and alleviated ferroptosis and endoplasmic reticulum (ER) stress in vivo and in vitro. A total of 1826 differentially expressed circRNAs were found (fold change >2, Q < 0.01), including 921 down-regulated and 905 up-regulated circRNAs in the injured brain tissues of TBI mice receiving melatonin treatment. Mechanistically, melatonin administration reduced the level of circPtpn14 (mmu_circ_0000130), which functioned by acting as a miR-351-5p sponge to positively regulate the expression of the ferroptosis-related 5-lipoxygenase (5-LOX). Moreover, circPtpn14 overexpression partly abolished the inhibitory effects of melatonin on ferroptosis. Collectively, our findings provide the first evidence that melatonin could exert anti-ferroptotic and anti-ER stress effects in brain injury by alleviating lipid peroxidation via the circPtpn14/miR-351-5p/5-LOX signaling.
[Display omitted]
There are several highlights of our study:•Iron accumulation in the corpus callosum was found in the chronic phase of TBI mice.•RNA-seq first demonstrated up- and down-regulated RNAs between TBI and melatonin treatment mice.•We predicted a circPtpn14-miRNA-ferroptosis drive genes ceRNA network.•CircPtpn14/miR-351-5p/5-LOX axis played an important role in melatonin anti-ferroptosis after TBI.•Hemin-induced activation of 5-LOX is highly associated with ER stress, implying a close link of ferroptosis and ER stress. |
---|---|
AbstractList | Traumatic brain injury (TBI) can lead to disability or devastating consequences with few established treatments. Although ferroptosis has been shown to be involved in TBI, the underlying mechanism was rarely known. Melatonin has been indicated to exhibit neuroprotective activities. However, the anti-ferroptotic effects of melatonin on TBI have not yet to be elucidated. We aimed to investigate whether ferroptosis was induced in humans after TBI and whether ferroptosis inhibition by melatonin could protect against blood-brain barrier (BBB) damage after TBI in vivo and in vitro. Circular RNAs (circRNAs) are highly expressed in the brain. For the first time, differentially expressed circRNA after melatonin treatment for TBI were detected by RNA sequencing. We found that lipid peroxidation was induced in humans after TBI, while melatonin significantly improved brain function of mice after TBI and alleviated ferroptosis and endoplasmic reticulum (ER) stress in vivo and in vitro. A total of 1826 differentially expressed circRNAs were found (fold change >2, Q < 0.01), including 921 down-regulated and 905 up-regulated circRNAs in the injured brain tissues of TBI mice receiving melatonin treatment. Mechanistically, melatonin administration reduced the level of circPtpn14 (mmu_circ_0000130), which functioned by acting as a miR-351-5p sponge to positively regulate the expression of the ferroptosis-related 5-lipoxygenase (5-LOX). Moreover, circPtpn14 overexpression partly abolished the inhibitory effects of melatonin on ferroptosis. Collectively, our findings provide the first evidence that melatonin could exert anti-ferroptotic and anti-ER stress effects in brain injury by alleviating lipid peroxidation via the circPtpn14/miR-351-5p/5-LOX signaling.
[Display omitted]
There are several highlights of our study:•Iron accumulation in the corpus callosum was found in the chronic phase of TBI mice.•RNA-seq first demonstrated up- and down-regulated RNAs between TBI and melatonin treatment mice.•We predicted a circPtpn14-miRNA-ferroptosis drive genes ceRNA network.•CircPtpn14/miR-351-5p/5-LOX axis played an important role in melatonin anti-ferroptosis after TBI.•Hemin-induced activation of 5-LOX is highly associated with ER stress, implying a close link of ferroptosis and ER stress. Traumatic brain injury (TBI) can lead to disability or devastating consequences with few established treatments. Although ferroptosis has been shown to be involved in TBI, the underlying mechanism was rarely known. Melatonin has been indicated to exhibit neuroprotective activities. However, the anti-ferroptotic effects of melatonin on TBI have not yet to be elucidated. We aimed to investigate whether ferroptosis was induced in humans after TBI and whether ferroptosis inhibition by melatonin could protect against blood-brain barrier (BBB) damage after TBI in vivo and in vitro. Circular RNAs (circRNAs) are highly expressed in the brain. For the first time, differentially expressed circRNA after melatonin treatment for TBI were detected by RNA sequencing. We found that lipid peroxidation was induced in humans after TBI, while melatonin significantly improved brain function of mice after TBI and alleviated ferroptosis and endoplasmic reticulum (ER) stress in vivo and in vitro. A total of 1826 differentially expressed circRNAs were found (fold change >2, Q < 0.01), including 921 down-regulated and 905 up-regulated circRNAs in the injured brain tissues of TBI mice receiving melatonin treatment. Mechanistically, melatonin administration reduced the level of circPtpn14 (mmu_circ_0000130), which functioned by acting as a miR-351-5p sponge to positively regulate the expression of the ferroptosis-related 5-lipoxygenase (5-LOX). Moreover, circPtpn14 overexpression partly abolished the inhibitory effects of melatonin on ferroptosis. Collectively, our findings provide the first evidence that melatonin could exert anti-ferroptotic and anti-ER stress effects in brain injury by alleviating lipid peroxidation via the circPtpn14/miR-351-5p/5-LOX signaling. |
Author | Fu, Jiayuanyuan Wu, Biying Cheng, Yuqi Wu, Chenrui Du, Mengran Liao, Z.B. Tan, Weilin Zhou, Qiang Yu, Renqiang Balawi, Ehab |
Author_xml | – sequence: 1 givenname: Chenrui orcidid: 0000-0002-4933-6918 surname: Wu fullname: Wu, Chenrui organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 2 givenname: Mengran surname: Du fullname: Du, Mengran organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 3 givenname: Renqiang surname: Yu fullname: Yu, Renqiang organization: Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 4 givenname: Yuqi surname: Cheng fullname: Cheng, Yuqi organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 5 givenname: Biying surname: Wu fullname: Wu, Biying organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 6 givenname: Jiayuanyuan surname: Fu fullname: Fu, Jiayuanyuan organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 7 givenname: Weilin surname: Tan fullname: Tan, Weilin organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 8 givenname: Qiang surname: Zhou fullname: Zhou, Qiang organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 9 givenname: Ehab orcidid: 0000-0003-1316-0268 surname: Balawi fullname: Balawi, Ehab organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China – sequence: 10 givenname: Z.B. orcidid: 0000-0003-4591-9689 surname: Liao fullname: Liao, Z.B. email: liaozb123@cqmu.edu.cn organization: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34883251$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkcFu1DAURS1URKeFX0CW2LBJxo4T2xGrqmoBqRIIgcTO8jgv7RsSO9jOSP0pvhGPpl2wY2VZPu_ed30vyJkPHgh5x1nNGZfbfT1GgGiHHYYZhrphDa95UzOmXpAN10pUbdfLM7JhuudVp9v-nFyktGeMtZ3Qr8i5aLUWTcc35M8V9eEAE53BPViPaaYT-l_o7-kIMYYlh4SJWj9Q8ENYJptmdDRCRrdO60xTjpASPaCl-QGow-i-5sXzdjvjt0p0ZYFl21V3X37ShPfeTkdp9MVvsjl49FXJgDbDQIuSzTP4TMNYLnadbXGhu2gLj36_xsfX5OVopwRvns5L8uP25vv1p6L_8fP11V3lWiFz5YZdLxR0I-t407TCKaYU9FIw7SRTmrVqdA6kdEMv-gLsuJSgJGg2QKNbcUnen3SXGH6vkLKZMTmYJushrMk0kumuhFN9QT-cUBdDShFGs0ScbXw0nJljYWZv_inMHAszvDGlsDL99slo3R3fnmefGyrAzQmAEveAEE1yCN6VT4vgshkC_pfRX9lrsuc |
CitedBy_id | crossref_primary_10_1038_s41388_024_03016_1 crossref_primary_10_1007_s11011_023_01323_2 crossref_primary_10_26508_lsa_202201804 crossref_primary_10_3390_antiox13040395 crossref_primary_10_1016_j_freeradbiomed_2022_10_303 crossref_primary_10_4103_1673_5374_374135 crossref_primary_10_18632_aging_205469 crossref_primary_10_1007_s11064_024_04202_z crossref_primary_10_1002_mco2_267 crossref_primary_10_18632_aging_205541 crossref_primary_10_1007_s12035_023_03321_y crossref_primary_10_1016_j_neuint_2023_105643 crossref_primary_10_1016_j_prp_2024_155203 crossref_primary_10_3389_fbioe_2023_1146111 crossref_primary_10_1016_j_neuroscience_2023_10_014 crossref_primary_10_1007_s10753_024_01989_5 crossref_primary_10_1055_a_2119_3229 crossref_primary_10_1016_j_bbrc_2022_12_014 crossref_primary_10_1007_s10735_024_10192_7 crossref_primary_10_1016_j_arr_2022_101717 crossref_primary_10_3389_fncel_2022_889765 crossref_primary_10_1021_acsami_4c05004 crossref_primary_10_1186_s13024_024_00728_6 crossref_primary_10_1016_j_ncrna_2023_09_004 crossref_primary_10_1007_s11064_023_03892_1 crossref_primary_10_1002_mco2_298 crossref_primary_10_1038_s41598_024_65666_1 crossref_primary_10_1002_ame2_12365 crossref_primary_10_3390_antiox13040493 crossref_primary_10_1016_j_brainresbull_2024_110991 crossref_primary_10_4103_1673_5374_350187 crossref_primary_10_1016_j_bcp_2023_115909 crossref_primary_10_1038_s41392_023_01720_0 crossref_primary_10_2147_COPD_S444402 crossref_primary_10_1089_rej_2023_0051 crossref_primary_10_3390_biomedicines11010005 crossref_primary_10_1016_j_ejmech_2024_116453 crossref_primary_10_1007_s12031_022_02017_7 crossref_primary_10_1016_j_brainres_2023_148689 crossref_primary_10_3389_fnmol_2022_974060 crossref_primary_10_3389_fnmol_2022_1005422 crossref_primary_10_1007_s12033_024_01140_7 crossref_primary_10_1002_brb3_3145 crossref_primary_10_1186_s12974_023_02716_x crossref_primary_10_1007_s12035_023_03267_1 crossref_primary_10_1080_10715762_2023_2244155 crossref_primary_10_1038_s41380_022_01711_7 crossref_primary_10_1016_j_jpha_2024_101012 crossref_primary_10_1155_2022_1274550 crossref_primary_10_1007_s11064_024_04193_x crossref_primary_10_1080_01616412_2023_2170905 crossref_primary_10_1177_0271678X241254772 crossref_primary_10_3390_antiox13030352 crossref_primary_10_4103_1673_5374_380870 crossref_primary_10_1016_j_freeradbiomed_2023_02_014 |
Cites_doi | 10.1089/neu.2017.5617 10.1111/jpi.12666 10.1146/annurev.bi.63.070194.002123 10.3390/brainsci9010010 10.1089/neu.2014.3680 10.3389/fcell.2020.00594 10.1016/j.freeradbiomed.2013.09.001 10.1007/s12035-014-8902-7 10.1021/acschembio.8b00199 10.1016/j.neuroscience.2019.12.018 10.1111/j.1468-2982.2009.01904.x 10.1007/s00109-017-1582-9 10.7554/eLife.02523 10.1161/STROKEAHA.116.015609 10.1016/j.braindev.2013.03.002 10.1038/aps.2017.103 10.3233/NRE-182583 10.4143/crt.2016.572 10.1016/bs.acdb.2020.08.001 10.1172/jci.insight.90777 10.1089/neu.2017.5243 10.1093/nar/gkl243 10.1016/j.bbagen.2012.11.020 10.1007/s10571-020-00850-1 10.3389/fncel.2020.603043 10.7150/thno.28029 10.4103/1673-5374.322467 10.1227/01.NEU.0000370893.04586.73 10.1034/j.1600-0633.2002.290404.x 10.1016/j.neubiorev.2015.04.010 10.1016/j.freeradbiomed.2007.03.034 10.1016/j.cell.2017.09.021 10.1152/physrev.00050.2017 10.1016/j.biomaterials.2019.119486 10.1111/jpi.12360 10.1093/nar/gkaa942 10.1038/s41589-019-0408-1 10.1111/jpi.12704 10.1016/j.cell.2012.03.042 10.1016/j.neuropharm.2018.08.004 10.1016/j.expneurol.2018.12.003 10.1093/bioinformatics/btp612 10.1007/s00415-019-09541-4 10.1007/s10571-017-0484-2 10.1080/09602011.2019.1682622 10.1016/j.arcmed.2013.04.002 10.1186/1471-2105-12-323 10.1093/bioinformatics/btn025 10.1016/j.neuroscience.2019.03.038 10.1523/JNEUROSCI.0914-18.2018 10.1007/s10571-004-1377-8 10.1016/j.cell.2013.12.010 10.1111/cns.13069 10.1089/neu.2017.5468 10.1016/j.biopha.2020.110251 10.1002/brb3.1453 10.3390/ijms19051539 10.1002/cphy.c140057 10.1021/acsnano.8b06399 10.1016/j.neuint.2008.12.002 10.1016/j.expneurol.2017.12.015 10.1111/jcmm.14511 10.1038/s42003-018-0212-6 10.1002/jcp.1041320115 10.2174/1871527317666180627120501 10.1038/s41576-019-0158-7 10.1038/s41598-017-06932-3 10.1111/j.1747-4949.2009.00387.x 10.1016/j.mce.2019.110687 10.1007/978-981-13-9589-5_1 10.5114/fn.2015.54419 10.1152/physrev.00032.2012 10.1038/nmeth.1923 10.1186/s12943-020-01157-x 10.1038/nmeth.3317 10.1016/j.molcel.2018.10.042 10.1371/journal.pone.0154427 10.1038/cdd.2015.93 10.18632/aging.103975 10.1080/15476286.2016.1255398 10.1016/j.redox.2020.101518 10.1177/0271678X18774666 10.1002/glia.23231 10.1089/neu.2018.6220 10.1016/j.neuron.2017.07.010 10.1016/j.freeradbiomed.2018.06.031 10.1111/jnc.14963 10.1093/nar/gkt1248 10.1159/000496922 |
ContentType | Journal Article |
Copyright | 2021 The Authors Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2021 The Authors – notice: Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.freeradbiomed.2021.12.007 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Biology |
EISSN | 1873-4596 |
EndPage | 294 |
ExternalDocumentID | 10_1016_j_freeradbiomed_2021_12_007 34883251 S0891584921008583 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M -~X .GJ .HR .~1 0R~ 1B1 1RT 1~. 1~5 29H 4.4 457 4G. 53G 5GY 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABBQC ABFNM ABFRF ABGSF ABJNI ABLJU ABLVK ABMAC ABMZM ABUDA ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HLW HMK HMO HVGLF HX~ HZ~ IHE J1W KOM LCYCR LX3 LZ2 M29 M41 MO0 N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SBG SCC SDF SDG SDP SES SEW SPCBC SSH SSU SSZ T5K TEORI WUQ XPP ZGI ~G- AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c436t-cdb937e5f0512243c7077e96308c6078047fcce66cd939243b166e76e80de2843 |
IEDL.DBID | AIKHN |
ISSN | 0891-5849 |
IngestDate | Fri Aug 16 11:34:37 EDT 2024 Thu Sep 26 15:19:55 EDT 2024 Sat Sep 28 08:17:17 EDT 2024 Fri Feb 23 02:40:33 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Melatonin BBB Traumatic brain injury circRNA Blood-brain barrier Ferroptosis microRNA TBI 5-LOX Endoplasmic reticulum stress |
Language | English |
License | This is an open access article under the CC BY-NC-ND license. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c436t-cdb937e5f0512243c7077e96308c6078047fcce66cd939243b166e76e80de2843 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-4933-6918 0000-0003-1316-0268 0000-0003-4591-9689 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0891584921008583 |
PMID | 34883251 |
PQID | 2608535179 |
PQPubID | 23479 |
PageCount | 24 |
ParticipantIDs | proquest_miscellaneous_2608535179 crossref_primary_10_1016_j_freeradbiomed_2021_12_007 pubmed_primary_34883251 elsevier_sciencedirect_doi_10_1016_j_freeradbiomed_2021_12_007 |
PublicationCentury | 2000 |
PublicationDate | January 2022 2022-01-00 20220101 |
PublicationDateYYYYMMDD | 2022-01-01 |
PublicationDate_xml | – month: 01 year: 2022 text: January 2022 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Free radical biology & medicine |
PublicationTitleAlternate | Free Radic Biol Med |
PublicationYear | 2022 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Osier, Carlson, DeSana, Dixon (bib2) 2015; 32 Kruit, van Buchem, Launer, Terwindt, Ferrari (bib97) 2010; 30 Gao, Yi, Zhu, Minikes, Monian, Thompson, Jiang (bib61) 2019; 73 Xu, Ding, Ji, Ao, Liu, Yu, Wang (bib56) 2019; 23 Khatri, Thakur, Pareek, Kumar, Sharma, Datusalia (bib15) 2018; 17 Hayano, Yang, Corn, Pagano, Stockwell (bib63) 2016; 23 Anthonymuthu, Kenny, Lamade, Kagan, Bayır (bib49) 2018; 124 Liu, Yang, Yang, Song, Han, Xie, Cheng, Xie, Chen, Jiang (bib41) 2019; 9 Conrad, Pratt (bib12) 2019; 15 Liu, Zhang, Zhang, Hu, He, Liu, Zhao, Liang, He, Li, Sun, Guo (bib17) 2019; 408 Zhu, Xing, Zhao, Hao, Li (bib45) 2020; 428 Wu, Zhang, Gong, Tam, Xiao, Liu, Tao (bib58) 2020; 19 Wickwire, Schnyer, Germain, Williams, Lettieri, McKeon, Scharf, Stocker, Albrecht, Badjatia, Markowitz, Manley (bib90) 2018; 35 Reiter, Mayo, Tan, Sainz, Alatorre-Jimenez, Qin (bib25) 2016; 61 Turner, Lucke-Wold, Robson, Omalu, Petraglia, Bailes (bib96) 2012; 3 Alluri, Wilson, Anasooya Shaji, Wiggins-Dohlvik, Patel, Liu, Peng, Beeram, Davis, Huang, Tharakan (bib80) 2016; 11 Khalaf, Ahmad, Chamara, Doré (bib5) 2018; 36 Stolwijk, Falls-Hubert, Searby, Wagner, Buettner (bib69) 2020; 32 Brigelius-Flohé, Maiorino (bib66) 2013 Rasch, Born (bib94) 2013; 93 Sweeney, Zhao, Montagne, Nelson, Zlokovic (bib4) 2019; 99 Deli, Abrahám, Kataoka, Niwa (bib40) 2005; 25 Li, Han, Lan, Gao, Wan, Durham, Cheng, Yang, Wang, Jiang, Ying, Koehler, Stockwell, Wang (bib10) 2017; 2 Castejón (bib65) 2015; 53 Assis-Nascimento, Tsenkina, Liebl (bib84) 2018; 9 Wang, Feng, Wang, Wang, Zhang (bib31) 2010; 26 Shen, Lin, Li, Wu, Lenahan, Pan, Xu, Chen, Shao, Zhang (bib19) 2020; 8 Dixon, Lemberg, Lamprecht, Skouta, Zaitsev, Gleason, Patel, Bauer, Cantley, Yang, Morrison, Stockwell (bib59) 2012; 149 Wolfe, Sahni, Attarian (bib88) 2018; 43 Gaschler, Hu, Feng, Linkermann, Min, Stockwell (bib18) 2018; 13 Maass, Glažar, Memczak, Dittmar, Hollfinger, Schreyer, Sauer, Toka, Aiuti, Luft, Rajewsky (bib32) 2017; 95 Brickler, Hazy, Guilhaume Correa, Dai, Kowalski, Dickerson, Chen, Wang, Morton, Whittington, Ahmed, Theus (bib82) 2018; 38 Guo, Xu, Han, Zhou, Xia, Gong, Dai, Li, Wu (bib70) 2018; 50 Osier, McGreevy, Pham, Puccio, Ren, Conley, Alexander, Dixon (bib24) 2018; 19 Zhou, Bao (bib35) 2020 Zetterling, Hallberg, Hillered, Karlsson, Enblad, Ronne Engström (bib75) 2010; 66 Lucke-Wold, Smith, Nguyen, Turner, Logsdon, Jackson, Huber, Rosen, Miller (bib91) 2015; 55 Keep, Andjelkovic, Xiang, Stamatovic, Antonetti, Hua, Xi (bib76) 2018; 38 Siflinger-Birnboim, Del Vecchio, Cooper, Blumenstock, Shepard, Malik (bib39) 1987; 132 Wang, Li, Qiao, Hu, Liao, Chen, Wu, Wu, Zhao, Liu, Chen, Ma, Kim, Sun, Davis, Chen, Tian, Hyeon, Ling (bib71) 2018; 12 Ko, Hemphill, Yang, Beard, Sewell, Shallcross, Schweizer, Sandsmark, Diaz-Arrastia, Kim, Meaney, Issadore (bib54) 2020; 37 Wu, He, Tian, Luo, Zhong, Zhang, Li, Cen, Jiang, Sun (bib44) 2020; 153 Cuzzocrea, Costantino, Gitto, Mazzon, Fulia, Serraino, Cordaro, Barberi, De Sarro, Caputi (bib77) 2000; 29 Dixon, Patel, Welsch, Skouta, Lee, Hayano, Thomas, Gleason, Tatonetti, Slusher, Stockwell (bib57) 2014; 3 Logsdon, Lucke-Wold, Turner, Huber, Rosen, Simpkins (bib85) 2015; 5 Lucke-Wold, Logsdon, Smith, Turner, Alkon, Tan, Naser, Knotts, Huber, Rosen (bib7) 2015; 52 Wang, Chang, Wu, Chiang, Chiu, Chen, Chang (bib87) 2021; 31 Hanan, Soreq, Kadener (bib21) 2017; 14 Luongo, Lukowski, Protho, Van Vorce, Pisani, Edgin (bib95) 2021; 60 Rui, Wang, Li, Cheng, Gao, Fang, Ma, Chen, Gao, Gu, Song, Zhang, Wang, Wang, Wang, Zhang, Min, Chen, Tao, Wang, Luo (bib14) 2021; 70 Allen, Bayraktutan (bib81) 2009; 4 Li, Dewey (bib30) 2011; 12 Li, Lu, Yao, Xu, Zhou, Zheng (bib47) 2020; 12 Thirupathi, Chang (bib6) 2019; 1173 Cheng, Wu, Du, Zhou, Wu, Fu, Balawi, Tan, Liao (bib22) 2022; 17 Xie, Wang, Lin, Zhao, Mao, Feng, Cao, Gao, Jiang (bib48) 2018; 35 Fong, Tay, Ong, Lai (bib92) 2017; 11 Stockwell, Friedmann Angeli, Bayir, Bush, Conrad, Dixon, Fulda, Gascón, Hatzios, Kagan, Noel, Jiang, Linkermann, Murphy, Overholtzer, Oyagi, Pagnussat, Park, Ran, Rosenfeld, Salnikow, Tang, Torti, Torti, Toyokuni, Woerpel, Zhang (bib8) 2017; 171 Koskenkorva-Frank, Weiss, Koppenol, Burckhardt (bib60) 2013; 65 Gorman (bib23) 2020; 503 Dehghan, Khaksari Hadad, Asadikram, Najafipour, Shahrokhi (bib78) 2013; 44 Liu, Xu, Yang, Yang, Ding, Chen, Yuan, Tian (bib83) 2017; 38 Nakagawa, Deli, Kawaguchi, Shimizudani, Shimono, Kittel, Tanaka, Niwa (bib38) 2009; 54 Shahrokhi, Khaksari, AsadiKaram, Soltani, Shahrokhi (bib79) 2018; 21 Rui, Li, Song, Gao, Luo (bib53) 2020; 35 Kim, Langmead, Salzberg (bib28) 2015; 12 Khellaf, Khan, Helmy (bib1) 2019; 266 Dzitoyeva, Imbesi, Ng, Manev (bib13) 2009 Magtanong, Dixon (bib11) 2018; 40 Langmead, Salzberg (bib29) 2012; 9 Kristensen, Andersen, Stagsted, Ebbesen, Hansen, Kjems (bib20) 2019; 20 Al-Ameri, Mohsin, Abdul Wahid (bib89) 2019; 9 Bektas, Arıca, Teber, Yılmaz, Zeybek, Kaymak, Deda (bib93) 2014; 36 Xie, Wang, Lin, Mao, Feng, Gao, Jiang (bib52) 2019; 25 Ford-Hutchinson, Gresser, Young (bib55) 1994; 63 Howe, Achuthan, Allen, Allen, Alvarez-Jarreta, Amode, Armean, Azov, Bennett, Bhai, Billis, Boddu, Charkhchi, Cummins, Da Rin Fioretto, Davidson, Dodiya, El Houdaigui, Fatima, Gall, Garcia Giron, Grego, Guijarro-Clarke, Haggerty, Hemrom, Hourlier, Izuogu, Juettemann, Kaikala, Kay, Lavidas, Le, Lemos, Gonzalez Martinez, Marugán, Maurel, McMahon, Mohanan, Moore, Muffato, Oheh, Paraschas, Parker, Parton, Prosovetskaia, Sakthivel, Salam, Schmitt, Schuilenburg, Sheppard, Steed, Szpak, Szuba, Taylor, Thormann, Threadgold, Walts, Winterbottom, Chakiachvili, Chaubal, De Silva, Flint, Frankish, Hunt, IIsley, Langridge, Loveland, Martin, Mudge, Morales, Perry, Ruffier, Tate, Thybert, Trevanion, Cunningham, Yates, Zerbino, Flicek (bib36) 2021; 49 Derry, Vo, Gnanansekaran, Mitra, Liopo, Hegde, Tsai, Tour, Kent (bib42) 2020; 14 Chen, Wang, Zhong, Yang, Darwazeh, Tian, Huang, Jiang, Cheng, Wu, Guo, Sun (bib46) 2019; 313 Muller, Lustgarten, Jang, Richardson, Van Remmen (bib67) 2007; 43 Li, Li, Kristiansen, Wang (bib27) 2008; 24 Li, Liu, Wu, Tian, Liu, Wang, Bihl, Shi (bib86) 2021; 41 Jha, Kochanek, Simard (bib73) 2019; 145 Li, Liu, Zhou, Qu, Yang (bib33) 2014; 42 Teng, Guo, Zhong, Cheng, Huang, Wu, Tang, Luo, Peng, Wu, Sun, Jiang (bib43) 2017; 7 Gao, Deng, Liu, Fan, Wang, Wu, Ding, Kong, Wang, Peer, Zhao (bib72) 2019; 223 Sun, Chen, Gu, Wang, Zhang (bib64) 2017; 37 Yang, SriRamaratnam, Welsch, Shimada, Skouta, Viswanathan, Cheah, Clemons, Shamji, Clish, Brown, Girotti, Cornish, Schreiber, Stockwell (bib68) 2014; 156 Huang, Wang, Cai, Qiu, Zheng, Lai, Sui, Wang, Lu, Zhang, Yuan, Gong, Cai, Liu, Shan, Deng, Shi, Shu, Zhang, Qiu, Peng, Ren, Lu, Xiang (bib37) 2018; 8 Ma, Wang, Zhang, Li, Zhao, Sun, Yang (bib26) 2020 Alborzinia, Ignashkova, Dejure, Gendarme, Theobald, Wölfl, Lindemann, Reiling (bib62) 2018; 1 Krüger, Rehmsmeier (bib34) 2006; 34 Ma, Liu, Jiang (bib50) 2020; 128 Wang, Han, Zhou, Zhang, Liu, Cao, Dong (bib51) 2020; 69 Zille, Karuppagounder, Chen, Gough, Bertin, Finger, Milner, Jonas, Ratan (bib9) 2017; 48 Zhao, Xiang, Zhang, Jiang, Liang, Qing, Liu, Zhao, He (bib16) 2018; 302 Stokum, Kwon, Woo, Tsymbalyuk, Vennekens, Gerzanich, Simard (bib74) 2018; 66 Jassam, Izzy, Whalen, McGavern, El Khoury (bib3) 2017; 95 Allen (10.1016/j.freeradbiomed.2021.12.007_bib81) 2009; 4 Fong (10.1016/j.freeradbiomed.2021.12.007_bib92) 2017; 11 Li (10.1016/j.freeradbiomed.2021.12.007_bib86) 2021; 41 Li (10.1016/j.freeradbiomed.2021.12.007_bib10) 2017; 2 Jha (10.1016/j.freeradbiomed.2021.12.007_bib73) 2019; 145 Wickwire (10.1016/j.freeradbiomed.2021.12.007_bib90) 2018; 35 Deli (10.1016/j.freeradbiomed.2021.12.007_bib40) 2005; 25 Khellaf (10.1016/j.freeradbiomed.2021.12.007_bib1) 2019; 266 Gaschler (10.1016/j.freeradbiomed.2021.12.007_bib18) 2018; 13 Ma (10.1016/j.freeradbiomed.2021.12.007_bib26) 2020 Luongo (10.1016/j.freeradbiomed.2021.12.007_bib95) 2021; 60 Xie (10.1016/j.freeradbiomed.2021.12.007_bib48) 2018; 35 Stokum (10.1016/j.freeradbiomed.2021.12.007_bib74) 2018; 66 Thirupathi (10.1016/j.freeradbiomed.2021.12.007_bib6) 2019; 1173 Lucke-Wold (10.1016/j.freeradbiomed.2021.12.007_bib91) 2015; 55 Hayano (10.1016/j.freeradbiomed.2021.12.007_bib63) 2016; 23 Chen (10.1016/j.freeradbiomed.2021.12.007_bib46) 2019; 313 Gao (10.1016/j.freeradbiomed.2021.12.007_bib72) 2019; 223 Wang (10.1016/j.freeradbiomed.2021.12.007_bib51) 2020; 69 Alborzinia (10.1016/j.freeradbiomed.2021.12.007_bib62) 2018; 1 Howe (10.1016/j.freeradbiomed.2021.12.007_bib36) 2021; 49 Stolwijk (10.1016/j.freeradbiomed.2021.12.007_bib69) 2020; 32 Reiter (10.1016/j.freeradbiomed.2021.12.007_bib25) 2016; 61 Wang (10.1016/j.freeradbiomed.2021.12.007_bib31) 2010; 26 Rui (10.1016/j.freeradbiomed.2021.12.007_bib53) 2020; 35 Sun (10.1016/j.freeradbiomed.2021.12.007_bib64) 2017; 37 Liu (10.1016/j.freeradbiomed.2021.12.007_bib83) 2017; 38 Maass (10.1016/j.freeradbiomed.2021.12.007_bib32) 2017; 95 Hanan (10.1016/j.freeradbiomed.2021.12.007_bib21) 2017; 14 Derry (10.1016/j.freeradbiomed.2021.12.007_bib42) 2020; 14 Langmead (10.1016/j.freeradbiomed.2021.12.007_bib29) 2012; 9 Koskenkorva-Frank (10.1016/j.freeradbiomed.2021.12.007_bib60) 2013; 65 Assis-Nascimento (10.1016/j.freeradbiomed.2021.12.007_bib84) 2018; 9 Castejón (10.1016/j.freeradbiomed.2021.12.007_bib65) 2015; 53 Sweeney (10.1016/j.freeradbiomed.2021.12.007_bib4) 2019; 99 Wolfe (10.1016/j.freeradbiomed.2021.12.007_bib88) 2018; 43 Dehghan (10.1016/j.freeradbiomed.2021.12.007_bib78) 2013; 44 Zhao (10.1016/j.freeradbiomed.2021.12.007_bib16) 2018; 302 Turner (10.1016/j.freeradbiomed.2021.12.007_bib96) 2012; 3 Ko (10.1016/j.freeradbiomed.2021.12.007_bib54) 2020; 37 Cheng (10.1016/j.freeradbiomed.2021.12.007_bib22) 2022; 17 Anthonymuthu (10.1016/j.freeradbiomed.2021.12.007_bib49) 2018; 124 Wang (10.1016/j.freeradbiomed.2021.12.007_bib87) 2021; 31 Liu (10.1016/j.freeradbiomed.2021.12.007_bib41) 2019; 9 Magtanong (10.1016/j.freeradbiomed.2021.12.007_bib11) 2018; 40 Rasch (10.1016/j.freeradbiomed.2021.12.007_bib94) 2013; 93 Cuzzocrea (10.1016/j.freeradbiomed.2021.12.007_bib77) 2000; 29 Logsdon (10.1016/j.freeradbiomed.2021.12.007_bib85) 2015; 5 Khalaf (10.1016/j.freeradbiomed.2021.12.007_bib5) 2018; 36 Teng (10.1016/j.freeradbiomed.2021.12.007_bib43) 2017; 7 Gao (10.1016/j.freeradbiomed.2021.12.007_bib61) 2019; 73 Ford-Hutchinson (10.1016/j.freeradbiomed.2021.12.007_bib55) 1994; 63 Stockwell (10.1016/j.freeradbiomed.2021.12.007_bib8) 2017; 171 Conrad (10.1016/j.freeradbiomed.2021.12.007_bib12) 2019; 15 Kim (10.1016/j.freeradbiomed.2021.12.007_bib28) 2015; 12 Bektas (10.1016/j.freeradbiomed.2021.12.007_bib93) 2014; 36 Liu (10.1016/j.freeradbiomed.2021.12.007_bib17) 2019; 408 Dixon (10.1016/j.freeradbiomed.2021.12.007_bib57) 2014; 3 Brickler (10.1016/j.freeradbiomed.2021.12.007_bib82) 2018; 38 Zetterling (10.1016/j.freeradbiomed.2021.12.007_bib75) 2010; 66 Li (10.1016/j.freeradbiomed.2021.12.007_bib33) 2014; 42 Gorman (10.1016/j.freeradbiomed.2021.12.007_bib23) 2020; 503 Siflinger-Birnboim (10.1016/j.freeradbiomed.2021.12.007_bib39) 1987; 132 Shen (10.1016/j.freeradbiomed.2021.12.007_bib19) 2020; 8 Krüger (10.1016/j.freeradbiomed.2021.12.007_bib34) 2006; 34 Muller (10.1016/j.freeradbiomed.2021.12.007_bib67) 2007; 43 Guo (10.1016/j.freeradbiomed.2021.12.007_bib70) 2018; 50 Xu (10.1016/j.freeradbiomed.2021.12.007_bib56) 2019; 23 Osier (10.1016/j.freeradbiomed.2021.12.007_bib2) 2015; 32 Li (10.1016/j.freeradbiomed.2021.12.007_bib47) 2020; 12 Xie (10.1016/j.freeradbiomed.2021.12.007_bib52) 2019; 25 Nakagawa (10.1016/j.freeradbiomed.2021.12.007_bib38) 2009; 54 Wu (10.1016/j.freeradbiomed.2021.12.007_bib58) 2020; 19 Kruit (10.1016/j.freeradbiomed.2021.12.007_bib97) 2010; 30 Huang (10.1016/j.freeradbiomed.2021.12.007_bib37) 2018; 8 Dzitoyeva (10.1016/j.freeradbiomed.2021.12.007_bib13) 2009 Khatri (10.1016/j.freeradbiomed.2021.12.007_bib15) 2018; 17 Zhou (10.1016/j.freeradbiomed.2021.12.007_bib35) 2020 Wu (10.1016/j.freeradbiomed.2021.12.007_bib44) 2020; 153 Wang (10.1016/j.freeradbiomed.2021.12.007_bib71) 2018; 12 Shahrokhi (10.1016/j.freeradbiomed.2021.12.007_bib79) 2018; 21 Li (10.1016/j.freeradbiomed.2021.12.007_bib30) 2011; 12 Zhu (10.1016/j.freeradbiomed.2021.12.007_bib45) 2020; 428 Rui (10.1016/j.freeradbiomed.2021.12.007_bib14) 2021; 70 Al-Ameri (10.1016/j.freeradbiomed.2021.12.007_bib89) 2019; 9 Osier (10.1016/j.freeradbiomed.2021.12.007_bib24) 2018; 19 Ma (10.1016/j.freeradbiomed.2021.12.007_bib50) 2020; 128 Kristensen (10.1016/j.freeradbiomed.2021.12.007_bib20) 2019; 20 Dixon (10.1016/j.freeradbiomed.2021.12.007_bib59) 2012; 149 Keep (10.1016/j.freeradbiomed.2021.12.007_bib76) 2018; 38 Alluri (10.1016/j.freeradbiomed.2021.12.007_bib80) 2016; 11 Li (10.1016/j.freeradbiomed.2021.12.007_bib27) 2008; 24 Brigelius-Flohé (10.1016/j.freeradbiomed.2021.12.007_bib66) 2013 Yang (10.1016/j.freeradbiomed.2021.12.007_bib68) 2014; 156 Zille (10.1016/j.freeradbiomed.2021.12.007_bib9) 2017; 48 Jassam (10.1016/j.freeradbiomed.2021.12.007_bib3) 2017; 95 Lucke-Wold (10.1016/j.freeradbiomed.2021.12.007_bib7) 2015; 52 |
References_xml | – volume: 7 start-page: 6649 year: 2017 ident: bib43 article-title: ApoE influences the blood-brain barrier through the NF-κB/MMP-9 pathway after traumatic brain injury publication-title: Sci. Rep. contributor: fullname: Jiang – volume: 40 start-page: 382 year: 2018 end-page: 395 ident: bib11 article-title: Ferroptosis and brain injury publication-title: Dev. Neurosci. contributor: fullname: Dixon – volume: 70 year: 2021 ident: bib14 article-title: Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury-induced ferroptosis publication-title: J. Pineal Res. contributor: fullname: Luo – volume: 302 start-page: 22 year: 2018 end-page: 33 ident: bib16 article-title: CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage publication-title: Exp. Neurol. contributor: fullname: He – volume: 73 start-page: 354 year: 2019 end-page: 363 ident: bib61 article-title: Role of mitochondria in ferroptosis publication-title: Mol. Cell contributor: fullname: Jiang – volume: 23 start-page: 4900 year: 2019 end-page: 4912 ident: bib56 article-title: Molecular mechanisms of ferroptosis and its role in cancer therapy publication-title: J. Cell Mol. Med. contributor: fullname: Wang – volume: 36 start-page: 130 year: 2014 end-page: 136 ident: bib93 article-title: Chloral hydrate and/or hydroxyzine for sedation in pediatric EEG recording publication-title: Brain Dev. contributor: fullname: Deda – volume: 1173 start-page: 1 year: 2019 end-page: 19 ident: bib6 article-title: Brain iron metabolism and CNS diseases publication-title: Adv. Exp. Med. Biol. contributor: fullname: Chang – volume: 63 start-page: 383 year: 1994 end-page: 417 ident: bib55 article-title: 5-Lipoxygenase publication-title: Annu Rev Biochem contributor: fullname: Young – volume: 54 start-page: 253 year: 2009 end-page: 263 ident: bib38 article-title: A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes publication-title: Neurochem. Int. contributor: fullname: Niwa – volume: 34 start-page: W451 year: 2006 end-page: W454 ident: bib34 article-title: microRNA target prediction easy, fast and flexible publication-title: Nucleic Acids Res. contributor: fullname: Rehmsmeier – volume: 53 start-page: 173 year: 2015 end-page: 192 ident: bib65 article-title: Biopathology of astrocytes in human traumatic and complicated brain injuries. Review and hypothesis publication-title: Folia Neuropathol. contributor: fullname: Castejón – volume: 26 start-page: 136 year: 2010 end-page: 138 ident: bib31 article-title: DEGseq: an R package for identifying differentially expressed genes from RNA-seq data publication-title: Bioinformatics contributor: fullname: Zhang – volume: 50 start-page: 445 year: 2018 end-page: 460 ident: bib70 article-title: A novel anti-tumor action for cisplatin publication-title: Cancer Res Treat contributor: fullname: Wu – volume: 11 start-page: CD011786 year: 2017 ident: bib92 article-title: Chloral hydrate as a sedating agent for neurodiagnostic procedures in children publication-title: Cochrane Database Syst. Rev. contributor: fullname: Lai – volume: 35 start-page: 1659 year: 2018 end-page: 1666 ident: bib48 article-title: Circular RNA expression profiles alter significantly after traumatic brain injury in rats publication-title: J. Neurotrauma contributor: fullname: Jiang – volume: 52 start-page: 1119 year: 2015 end-page: 1134 ident: bib7 article-title: Bryostatin-1 restores blood brain barrier integrity following blast-induced traumatic brain injury publication-title: Mol. Neurobiol. contributor: fullname: Rosen – volume: 9 year: 2019 ident: bib41 article-title: Effects of early postnatal exposure to fine particulate matter on emotional and cognitive development and structural synaptic plasticity in immature and mature rats publication-title: Brain Behav contributor: fullname: Jiang – volume: 44 start-page: 251 year: 2013 end-page: 258 ident: bib78 article-title: Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses publication-title: Arch. Med. Res. contributor: fullname: Shahrokhi – volume: 8 start-page: 594 year: 2020 ident: bib19 article-title: Ferroptosis in acute central nervous system injuries: the future direction publication-title: Front Cell Dev Biol contributor: fullname: Zhang – volume: 223 start-page: 119486 year: 2019 ident: bib72 article-title: Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy publication-title: Biomaterials contributor: fullname: Zhao – volume: 9 year: 2019 ident: bib89 article-title: Sleep disorders following mild and moderate traumatic brain injury publication-title: Brain Sci. contributor: fullname: Abdul Wahid – volume: 93 start-page: 681 year: 2013 end-page: 766 ident: bib94 article-title: About sleep's role in memory publication-title: Physiol. Rev. contributor: fullname: Born – volume: 19 start-page: 39 year: 2020 ident: bib58 article-title: The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression publication-title: Mol. Cancer contributor: fullname: Tao – volume: 503 start-page: 110687 year: 2020 ident: bib23 article-title: Temporal organization of pineal melatonin signaling in mammals publication-title: Mol. Cell. Endocrinol. contributor: fullname: Gorman – volume: 23 start-page: 270 year: 2016 end-page: 278 ident: bib63 article-title: Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation publication-title: Cell Death Differ. contributor: fullname: Stockwell – volume: 428 start-page: 50 year: 2020 end-page: 59 ident: bib45 article-title: The role of circular RNAs in brain injury publication-title: Neuroscience contributor: fullname: Li – start-page: 9067610 year: 2020 ident: bib26 article-title: Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in type 2 diabetic osteoporosis publication-title: Oxid Med Cell Longev contributor: fullname: Yang – volume: 3 year: 2014 ident: bib57 article-title: Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis publication-title: Elife contributor: fullname: Stockwell – volume: 12 start-page: 12380 year: 2018 end-page: 12392 ident: bib71 article-title: Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics publication-title: ACS Nano contributor: fullname: Ling – volume: 60 start-page: 229 year: 2021 end-page: 260 ident: bib95 article-title: Sleep's role in memory consolidation: what can we learn from atypical development publication-title: Adv. Child Dev. Behav. contributor: fullname: Edgin – volume: 153 start-page: 710 year: 2020 end-page: 726 ident: bib44 article-title: microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury publication-title: J. Neurochem. contributor: fullname: Sun – volume: 48 start-page: 1033 year: 2017 end-page: 1043 ident: bib9 article-title: Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis publication-title: Stroke contributor: fullname: Ratan – volume: 9 year: 2018 ident: bib84 article-title: EphB3 signaling induces cortical endothelial cell death and disrupts the blood-brain barrier after traumatic brain injury publication-title: Cell Death Dis. contributor: fullname: Liebl – volume: 19 year: 2018 ident: bib24 article-title: Melatonin as a therapy for traumatic brain injury: a review of published evidence publication-title: Int. J. Mol. Sci. contributor: fullname: Dixon – volume: 12 start-page: 357 year: 2015 end-page: 360 ident: bib28 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods contributor: fullname: Salzberg – volume: 31 start-page: 211 year: 2021 end-page: 230 ident: bib87 article-title: Increased short- and long-term risk of sleep disorders in people with traumatic brain injury publication-title: Neuropsychol. Rehabil. contributor: fullname: Chang – volume: 2 year: 2017 ident: bib10 article-title: Inhibition of neuronal ferroptosis protects hemorrhagic brain publication-title: JCI Insight contributor: fullname: Wang – volume: 32 start-page: 1861 year: 2015 end-page: 1882 ident: bib2 article-title: Chronic histopathological and behavioral outcomes of experimental traumatic brain injury in adult male animals publication-title: J. Neurotrauma contributor: fullname: Dixon – volume: 61 start-page: 253 year: 2016 end-page: 278 ident: bib25 article-title: Melatonin as an antioxidant: under promises but over delivers publication-title: J. Pineal Res. contributor: fullname: Qin – volume: 38 start-page: 9618 year: 2018 end-page: 9634 ident: bib82 article-title: Angiopoietin/Tie2 Axis regulates the age-at-injury cerebrovascular response to traumatic brain injury publication-title: J. Neurosci. contributor: fullname: Theus – volume: 42 start-page: D92 year: 2014 end-page: D97 ident: bib33 article-title: starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data publication-title: Nucleic Acids Res. contributor: fullname: Yang – volume: 55 start-page: 68 year: 2015 end-page: 77 ident: bib91 article-title: Sleep disruption and the sequelae associated with traumatic brain injury publication-title: Neurosci. Biobehav. Rev. contributor: fullname: Miller – volume: 32 start-page: 101518 year: 2020 ident: bib69 article-title: Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments publication-title: Redox Biol contributor: fullname: Buettner – volume: 30 start-page: 129 year: 2010 end-page: 136 ident: bib97 article-title: Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI CAMERA study publication-title: Cephalalgia contributor: fullname: Ferrari – volume: 24 start-page: 713 year: 2008 end-page: 714 ident: bib27 article-title: SOAP: short oligonucleotide alignment program publication-title: Bioinformatics contributor: fullname: Wang – volume: 35 start-page: 1105 year: 2020 end-page: 1113 ident: bib53 article-title: Ferroptosis-relevant mechanisms and biomarkers for therapeutic interventions in traumatic brain injury publication-title: Histol. Histopathol. contributor: fullname: Luo – volume: 38 start-page: 1445 year: 2017 end-page: 1455 ident: bib83 article-title: Sesamin alleviates blood-brain barrier disruption in mice with experimental traumatic brain injury publication-title: Acta Pharmacol. Sin. contributor: fullname: Tian – volume: 49 start-page: D884 year: 2021 end-page: D891 ident: bib36 publication-title: Nucleic Acids Res. contributor: fullname: Flicek – volume: 43 start-page: 477 year: 2007 end-page: 503 ident: bib67 article-title: Trends in oxidative aging theories publication-title: Free Radic. Biol. Med. contributor: fullname: Van Remmen – volume: 13 start-page: 1013 year: 2018 end-page: 1020 ident: bib18 article-title: Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis publication-title: ACS Chem. Biol. contributor: fullname: Stockwell – volume: 8 start-page: 5929 year: 2018 end-page: 5944 ident: bib37 article-title: Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation publication-title: Theranostics contributor: fullname: Xiang – volume: 37 start-page: 2424 year: 2020 end-page: 2434 ident: bib54 article-title: Multi-dimensional mapping of brain-derived extracellular vesicle MicroRNA biomarker for traumatic brain injury diagnostics publication-title: J. Neurotrauma contributor: fullname: Issadore – volume: 14 start-page: 603043 year: 2020 ident: bib42 article-title: The chemical basis of intracerebral hemorrhage and cell toxicity with contributions from eryptosis and ferroptosis publication-title: Front. Cell. Neurosci. contributor: fullname: Kent – volume: 15 start-page: 1137 year: 2019 end-page: 1147 ident: bib12 article-title: The chemical basis of ferroptosis publication-title: Nat. Chem. Biol. contributor: fullname: Pratt – volume: 171 start-page: 273 year: 2017 end-page: 285 ident: bib8 article-title: Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease publication-title: Cell contributor: fullname: Zhang – volume: 69 year: 2020 ident: bib51 article-title: Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells publication-title: J. Pineal Res. contributor: fullname: Dong – start-page: 2020 year: 2020 ident: bib35 article-title: A Manually Curated Resource for Regulators and Markers of Ferroptosis and Ferroptosis-Disease Associations contributor: fullname: Bao – volume: 25 start-page: 59 year: 2005 end-page: 127 ident: bib40 article-title: Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology publication-title: Cell. Mol. Neurobiol. contributor: fullname: Niwa – volume: 35 start-page: 2615 year: 2018 end-page: 2631 ident: bib90 article-title: Sleep, sleep disorders, and circadian health following mild traumatic brain injury in adults: review and research agenda publication-title: J. Neurotrauma contributor: fullname: Manley – volume: 36 start-page: 43 year: 2018 end-page: 53 ident: bib5 article-title: Unique properties associated with the brain penetrant iron chelator HBED reveal remarkable beneficial effects after brain trauma publication-title: J. Neurotrauma contributor: fullname: Doré – volume: 17 start-page: 689 year: 2018 end-page: 695 ident: bib15 article-title: Oxidative stress: major threat in traumatic brain injury publication-title: CNS Neurol. Disord. - Drug Targets contributor: fullname: Datusalia – volume: 12 start-page: 21687 year: 2020 end-page: 21705 ident: bib47 article-title: Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury publication-title: Aging (Albany NY) contributor: fullname: Zheng – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: bib29 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods contributor: fullname: Salzberg – volume: 1 start-page: 210 year: 2018 ident: bib62 article-title: Golgi stress mediates redox imbalance and ferroptosis in human cells publication-title: Commun Biol contributor: fullname: Reiling – volume: 65 start-page: 1174 year: 2013 end-page: 1194 ident: bib60 article-title: The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress publication-title: Free Radic. Biol. Med. contributor: fullname: Burckhardt – volume: 4 start-page: 461 year: 2009 end-page: 470 ident: bib81 article-title: Oxidative stress and its role in the pathogenesis of ischaemic stroke publication-title: Int. J. Stroke contributor: fullname: Bayraktutan – volume: 128 start-page: 110251 year: 2020 ident: bib50 article-title: CircRNAs: A new perspective of biomarkers in the nervous system publication-title: Biomed. Pharmacother. contributor: fullname: Jiang – volume: 17 start-page: 812 year: 2022 end-page: 818 ident: bib22 article-title: CircLphn3 protects the blood-brain barrier in traumatic brain injury publication-title: Neural Regen Res contributor: fullname: Liao – volume: 66 start-page: 108 year: 2018 end-page: 125 ident: bib74 article-title: SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling publication-title: Glia contributor: fullname: Simard – volume: 3 start-page: 186 year: 2012 ident: bib96 article-title: Repetitive traumatic brain injury and development of chronic traumatic encephalopathy: a potential role for biomarkers in diagnosis, prognosis, and treatment publication-title: Front. Neurol. contributor: fullname: Bailes – volume: 313 start-page: 37 year: 2019 end-page: 48 ident: bib46 article-title: Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury publication-title: Exp. Neurol. contributor: fullname: Sun – volume: 156 start-page: 317 year: 2014 end-page: 331 ident: bib68 article-title: Regulation of ferroptotic cancer cell death by GPX4 publication-title: Cell contributor: fullname: Stockwell – volume: 21 start-page: 301 year: 2018 end-page: 308 ident: bib79 article-title: Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury publication-title: Iran J Basic Med Sci contributor: fullname: Shahrokhi – volume: 25 start-page: 465 year: 2019 end-page: 475 ident: bib52 article-title: Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice publication-title: CNS Neurosci. Ther. contributor: fullname: Jiang – volume: 266 start-page: 2878 year: 2019 end-page: 2889 ident: bib1 article-title: Recent advances in traumatic brain injury publication-title: J. Neurol. contributor: fullname: Helmy – volume: 11 year: 2016 ident: bib80 article-title: Melatonin preserves blood-brain barrier integrity and permeability via matrix metalloproteinase-9 inhibition publication-title: PLoS One contributor: fullname: Tharakan – volume: 149 start-page: 1060 year: 2012 end-page: 1072 ident: bib59 article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death publication-title: Cell contributor: fullname: Stockwell – start-page: 3289 year: 2013 end-page: 3303 ident: bib66 article-title: Glutathione peroxidases publication-title: Biochim. Biophys. Acta contributor: fullname: Maiorino – volume: 29 start-page: 217 year: 2000 end-page: 227 ident: bib77 article-title: Protective effects of melatonin in ischemic brain injury publication-title: J. Pineal Res. contributor: fullname: Caputi – volume: 95 start-page: 1179 year: 2017 end-page: 1189 ident: bib32 article-title: A map of human circular RNAs in clinically relevant tissues publication-title: J. Mol. Med. (Berl.) contributor: fullname: Rajewsky – volume: 99 start-page: 21 year: 2019 end-page: 78 ident: bib4 article-title: Blood-brain barrier: from physiology to disease and back publication-title: Physiol. Rev. contributor: fullname: Zlokovic – volume: 14 start-page: 1028 year: 2017 end-page: 1034 ident: bib21 article-title: CircRNAs in the brain publication-title: RNA Biol. contributor: fullname: Kadener – volume: 41 start-page: 263 year: 2021 end-page: 278 ident: bib86 article-title: Inhibition of ferroptosis alleviates early brain injury after subarachnoid hemorrhage in vitro and in vivo via reduction of lipid peroxidation publication-title: Cell. Mol. Neurobiol. contributor: fullname: Shi – volume: 95 start-page: 1246 year: 2017 end-page: 1265 ident: bib3 article-title: Neuroimmunology of traumatic brain injury: time for a paradigm shift publication-title: Neuron contributor: fullname: El Khoury – volume: 408 start-page: 105 year: 2019 end-page: 114 ident: bib17 article-title: LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats publication-title: Neuroscience contributor: fullname: Guo – volume: 124 start-page: 493 year: 2018 end-page: 503 ident: bib49 article-title: Oxidized phospholipid signaling in traumatic brain injury publication-title: Free Radic. Biol. Med. contributor: fullname: Bayır – volume: 38 start-page: 1255 year: 2018 end-page: 1275 ident: bib76 article-title: Brain endothelial cell junctions after cerebral hemorrhage: changes, mechanisms and therapeutic targets publication-title: J. Cerebr. Blood Flow Metabol. contributor: fullname: Xi – volume: 43 start-page: 257 year: 2018 end-page: 266 ident: bib88 article-title: Sleep disorders in traumatic brain injury publication-title: NeuroRehabilitation contributor: fullname: Attarian – volume: 12 start-page: 323 year: 2011 ident: bib30 article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome publication-title: BMC Bioinf. contributor: fullname: Dewey – volume: 66 start-page: 1102 year: 2010 end-page: 1110 ident: bib75 article-title: Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema publication-title: Neurosurgery contributor: fullname: Ronne Engström – volume: 132 start-page: 111 year: 1987 end-page: 117 ident: bib39 article-title: Molecular sieving characteristics of the cultured endothelial monolayer publication-title: J. Cell. Physiol. contributor: fullname: Malik – start-page: 209596 year: 2009 ident: bib13 article-title: 5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice publication-title: Neural Plast. contributor: fullname: Manev – volume: 37 start-page: 1349 year: 2017 end-page: 1357 ident: bib64 article-title: Potential roles of mitochondria-associated ER membranes (MAMs) in traumatic brain injury publication-title: Cell. Mol. Neurobiol. contributor: fullname: Zhang – volume: 20 start-page: 675 year: 2019 end-page: 691 ident: bib20 article-title: The biogenesis, biology and characterization of circular RNAs publication-title: Nat. Rev. Genet. contributor: fullname: Kjems – volume: 145 start-page: 230 year: 2019 end-page: 246 ident: bib73 article-title: Pathophysiology and treatment of cerebral edema in traumatic brain injury publication-title: Neuropharmacology contributor: fullname: Simard – volume: 5 start-page: 1147 year: 2015 end-page: 1160 ident: bib85 article-title: Role of microvascular disruption in brain damage from traumatic brain injury publication-title: Comp. Physiol. contributor: fullname: Simpkins – volume: 36 start-page: 43 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib5 article-title: Unique properties associated with the brain penetrant iron chelator HBED reveal remarkable beneficial effects after brain trauma publication-title: J. Neurotrauma doi: 10.1089/neu.2017.5617 contributor: fullname: Khalaf – volume: 69 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib51 article-title: Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells publication-title: J. Pineal Res. doi: 10.1111/jpi.12666 contributor: fullname: Wang – volume: 63 start-page: 383 year: 1994 ident: 10.1016/j.freeradbiomed.2021.12.007_bib55 article-title: 5-Lipoxygenase publication-title: Annu Rev Biochem doi: 10.1146/annurev.bi.63.070194.002123 contributor: fullname: Ford-Hutchinson – volume: 21 start-page: 301 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib79 article-title: Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury publication-title: Iran J Basic Med Sci contributor: fullname: Shahrokhi – volume: 9 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib89 article-title: Sleep disorders following mild and moderate traumatic brain injury publication-title: Brain Sci. doi: 10.3390/brainsci9010010 contributor: fullname: Al-Ameri – volume: 32 start-page: 1861 year: 2015 ident: 10.1016/j.freeradbiomed.2021.12.007_bib2 article-title: Chronic histopathological and behavioral outcomes of experimental traumatic brain injury in adult male animals publication-title: J. Neurotrauma doi: 10.1089/neu.2014.3680 contributor: fullname: Osier – volume: 8 start-page: 594 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib19 article-title: Ferroptosis in acute central nervous system injuries: the future direction publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2020.00594 contributor: fullname: Shen – volume: 65 start-page: 1174 year: 2013 ident: 10.1016/j.freeradbiomed.2021.12.007_bib60 article-title: The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2013.09.001 contributor: fullname: Koskenkorva-Frank – volume: 52 start-page: 1119 year: 2015 ident: 10.1016/j.freeradbiomed.2021.12.007_bib7 article-title: Bryostatin-1 restores blood brain barrier integrity following blast-induced traumatic brain injury publication-title: Mol. Neurobiol. doi: 10.1007/s12035-014-8902-7 contributor: fullname: Lucke-Wold – volume: 13 start-page: 1013 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib18 article-title: Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis publication-title: ACS Chem. Biol. doi: 10.1021/acschembio.8b00199 contributor: fullname: Gaschler – volume: 428 start-page: 50 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib45 article-title: The role of circular RNAs in brain injury publication-title: Neuroscience doi: 10.1016/j.neuroscience.2019.12.018 contributor: fullname: Zhu – volume: 30 start-page: 129 year: 2010 ident: 10.1016/j.freeradbiomed.2021.12.007_bib97 article-title: Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI CAMERA study publication-title: Cephalalgia doi: 10.1111/j.1468-2982.2009.01904.x contributor: fullname: Kruit – volume: 95 start-page: 1179 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib32 article-title: A map of human circular RNAs in clinically relevant tissues publication-title: J. Mol. Med. (Berl.) doi: 10.1007/s00109-017-1582-9 contributor: fullname: Maass – volume: 3 year: 2014 ident: 10.1016/j.freeradbiomed.2021.12.007_bib57 article-title: Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis publication-title: Elife doi: 10.7554/eLife.02523 contributor: fullname: Dixon – volume: 35 start-page: 1105 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib53 article-title: Ferroptosis-relevant mechanisms and biomarkers for therapeutic interventions in traumatic brain injury publication-title: Histol. Histopathol. contributor: fullname: Rui – volume: 48 start-page: 1033 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib9 article-title: Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis publication-title: Stroke doi: 10.1161/STROKEAHA.116.015609 contributor: fullname: Zille – volume: 36 start-page: 130 year: 2014 ident: 10.1016/j.freeradbiomed.2021.12.007_bib93 article-title: Chloral hydrate and/or hydroxyzine for sedation in pediatric EEG recording publication-title: Brain Dev. doi: 10.1016/j.braindev.2013.03.002 contributor: fullname: Bektas – volume: 38 start-page: 1445 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib83 article-title: Sesamin alleviates blood-brain barrier disruption in mice with experimental traumatic brain injury publication-title: Acta Pharmacol. Sin. doi: 10.1038/aps.2017.103 contributor: fullname: Liu – volume: 43 start-page: 257 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib88 article-title: Sleep disorders in traumatic brain injury publication-title: NeuroRehabilitation doi: 10.3233/NRE-182583 contributor: fullname: Wolfe – volume: 50 start-page: 445 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib70 article-title: A novel anti-tumor action for cisplatin publication-title: Cancer Res Treat doi: 10.4143/crt.2016.572 contributor: fullname: Guo – volume: 60 start-page: 229 year: 2021 ident: 10.1016/j.freeradbiomed.2021.12.007_bib95 article-title: Sleep's role in memory consolidation: what can we learn from atypical development publication-title: Adv. Child Dev. Behav. doi: 10.1016/bs.acdb.2020.08.001 contributor: fullname: Luongo – volume: 2 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib10 article-title: Inhibition of neuronal ferroptosis protects hemorrhagic brain publication-title: JCI Insight doi: 10.1172/jci.insight.90777 contributor: fullname: Li – volume: 35 start-page: 2615 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib90 article-title: Sleep, sleep disorders, and circadian health following mild traumatic brain injury in adults: review and research agenda publication-title: J. Neurotrauma doi: 10.1089/neu.2017.5243 contributor: fullname: Wickwire – volume: 34 start-page: W451 year: 2006 ident: 10.1016/j.freeradbiomed.2021.12.007_bib34 article-title: microRNA target prediction easy, fast and flexible publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl243 contributor: fullname: Krüger – start-page: 3289 year: 2013 ident: 10.1016/j.freeradbiomed.2021.12.007_bib66 article-title: Glutathione peroxidases publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagen.2012.11.020 contributor: fullname: Brigelius-Flohé – volume: 41 start-page: 263 year: 2021 ident: 10.1016/j.freeradbiomed.2021.12.007_bib86 article-title: Inhibition of ferroptosis alleviates early brain injury after subarachnoid hemorrhage in vitro and in vivo via reduction of lipid peroxidation publication-title: Cell. Mol. Neurobiol. doi: 10.1007/s10571-020-00850-1 contributor: fullname: Li – volume: 14 start-page: 603043 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib42 article-title: The chemical basis of intracerebral hemorrhage and cell toxicity with contributions from eryptosis and ferroptosis publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2020.603043 contributor: fullname: Derry – volume: 8 start-page: 5929 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib37 article-title: Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation publication-title: Theranostics doi: 10.7150/thno.28029 contributor: fullname: Huang – start-page: 2020 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib35 contributor: fullname: Zhou – volume: 17 start-page: 812 year: 2022 ident: 10.1016/j.freeradbiomed.2021.12.007_bib22 article-title: CircLphn3 protects the blood-brain barrier in traumatic brain injury publication-title: Neural Regen Res doi: 10.4103/1673-5374.322467 contributor: fullname: Cheng – volume: 66 start-page: 1102 year: 2010 ident: 10.1016/j.freeradbiomed.2021.12.007_bib75 article-title: Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema publication-title: Neurosurgery doi: 10.1227/01.NEU.0000370893.04586.73 contributor: fullname: Zetterling – volume: 9 issue: 7 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib84 article-title: EphB3 signaling induces cortical endothelial cell death and disrupts the blood-brain barrier after traumatic brain injury publication-title: Cell Death Dis. contributor: fullname: Assis-Nascimento – volume: 29 start-page: 217 year: 2000 ident: 10.1016/j.freeradbiomed.2021.12.007_bib77 article-title: Protective effects of melatonin in ischemic brain injury publication-title: J. Pineal Res. doi: 10.1034/j.1600-0633.2002.290404.x contributor: fullname: Cuzzocrea – volume: 55 start-page: 68 year: 2015 ident: 10.1016/j.freeradbiomed.2021.12.007_bib91 article-title: Sleep disruption and the sequelae associated with traumatic brain injury publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2015.04.010 contributor: fullname: Lucke-Wold – volume: 43 start-page: 477 year: 2007 ident: 10.1016/j.freeradbiomed.2021.12.007_bib67 article-title: Trends in oxidative aging theories publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2007.03.034 contributor: fullname: Muller – volume: 171 start-page: 273 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib8 article-title: Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease publication-title: Cell doi: 10.1016/j.cell.2017.09.021 contributor: fullname: Stockwell – volume: 99 start-page: 21 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib4 article-title: Blood-brain barrier: from physiology to disease and back publication-title: Physiol. Rev. doi: 10.1152/physrev.00050.2017 contributor: fullname: Sweeney – volume: 223 start-page: 119486 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib72 article-title: Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2019.119486 contributor: fullname: Gao – volume: 61 start-page: 253 year: 2016 ident: 10.1016/j.freeradbiomed.2021.12.007_bib25 article-title: Melatonin as an antioxidant: under promises but over delivers publication-title: J. Pineal Res. doi: 10.1111/jpi.12360 contributor: fullname: Reiter – volume: 49 start-page: D884 year: 2021 ident: 10.1016/j.freeradbiomed.2021.12.007_bib36 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkaa942 contributor: fullname: Howe – volume: 11 start-page: CD011786 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib92 article-title: Chloral hydrate as a sedating agent for neurodiagnostic procedures in children publication-title: Cochrane Database Syst. Rev. contributor: fullname: Fong – volume: 15 start-page: 1137 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib12 article-title: The chemical basis of ferroptosis publication-title: Nat. Chem. Biol. doi: 10.1038/s41589-019-0408-1 contributor: fullname: Conrad – volume: 70 year: 2021 ident: 10.1016/j.freeradbiomed.2021.12.007_bib14 article-title: Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury-induced ferroptosis publication-title: J. Pineal Res. doi: 10.1111/jpi.12704 contributor: fullname: Rui – volume: 149 start-page: 1060 year: 2012 ident: 10.1016/j.freeradbiomed.2021.12.007_bib59 article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death publication-title: Cell doi: 10.1016/j.cell.2012.03.042 contributor: fullname: Dixon – volume: 145 start-page: 230 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib73 article-title: Pathophysiology and treatment of cerebral edema in traumatic brain injury publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2018.08.004 contributor: fullname: Jha – volume: 313 start-page: 37 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib46 article-title: Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2018.12.003 contributor: fullname: Chen – volume: 26 start-page: 136 year: 2010 ident: 10.1016/j.freeradbiomed.2021.12.007_bib31 article-title: DEGseq: an R package for identifying differentially expressed genes from RNA-seq data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp612 contributor: fullname: Wang – volume: 266 start-page: 2878 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib1 article-title: Recent advances in traumatic brain injury publication-title: J. Neurol. doi: 10.1007/s00415-019-09541-4 contributor: fullname: Khellaf – volume: 3 start-page: 186 year: 2012 ident: 10.1016/j.freeradbiomed.2021.12.007_bib96 article-title: Repetitive traumatic brain injury and development of chronic traumatic encephalopathy: a potential role for biomarkers in diagnosis, prognosis, and treatment publication-title: Front. Neurol. contributor: fullname: Turner – volume: 37 start-page: 1349 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib64 article-title: Potential roles of mitochondria-associated ER membranes (MAMs) in traumatic brain injury publication-title: Cell. Mol. Neurobiol. doi: 10.1007/s10571-017-0484-2 contributor: fullname: Sun – volume: 31 start-page: 211 year: 2021 ident: 10.1016/j.freeradbiomed.2021.12.007_bib87 article-title: Increased short- and long-term risk of sleep disorders in people with traumatic brain injury publication-title: Neuropsychol. Rehabil. doi: 10.1080/09602011.2019.1682622 contributor: fullname: Wang – volume: 44 start-page: 251 year: 2013 ident: 10.1016/j.freeradbiomed.2021.12.007_bib78 article-title: Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses publication-title: Arch. Med. Res. doi: 10.1016/j.arcmed.2013.04.002 contributor: fullname: Dehghan – volume: 12 start-page: 323 year: 2011 ident: 10.1016/j.freeradbiomed.2021.12.007_bib30 article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome publication-title: BMC Bioinf. doi: 10.1186/1471-2105-12-323 contributor: fullname: Li – volume: 24 start-page: 713 year: 2008 ident: 10.1016/j.freeradbiomed.2021.12.007_bib27 article-title: SOAP: short oligonucleotide alignment program publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn025 contributor: fullname: Li – volume: 408 start-page: 105 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib17 article-title: LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats publication-title: Neuroscience doi: 10.1016/j.neuroscience.2019.03.038 contributor: fullname: Liu – volume: 38 start-page: 9618 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib82 article-title: Angiopoietin/Tie2 Axis regulates the age-at-injury cerebrovascular response to traumatic brain injury publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0914-18.2018 contributor: fullname: Brickler – volume: 25 start-page: 59 year: 2005 ident: 10.1016/j.freeradbiomed.2021.12.007_bib40 article-title: Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology publication-title: Cell. Mol. Neurobiol. doi: 10.1007/s10571-004-1377-8 contributor: fullname: Deli – volume: 156 start-page: 317 year: 2014 ident: 10.1016/j.freeradbiomed.2021.12.007_bib68 article-title: Regulation of ferroptotic cancer cell death by GPX4 publication-title: Cell doi: 10.1016/j.cell.2013.12.010 contributor: fullname: Yang – volume: 25 start-page: 465 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib52 article-title: Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice publication-title: CNS Neurosci. Ther. doi: 10.1111/cns.13069 contributor: fullname: Xie – volume: 35 start-page: 1659 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib48 article-title: Circular RNA expression profiles alter significantly after traumatic brain injury in rats publication-title: J. Neurotrauma doi: 10.1089/neu.2017.5468 contributor: fullname: Xie – volume: 128 start-page: 110251 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib50 article-title: CircRNAs: A new perspective of biomarkers in the nervous system publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2020.110251 contributor: fullname: Ma – volume: 9 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib41 article-title: Effects of early postnatal exposure to fine particulate matter on emotional and cognitive development and structural synaptic plasticity in immature and mature rats publication-title: Brain Behav doi: 10.1002/brb3.1453 contributor: fullname: Liu – volume: 19 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib24 article-title: Melatonin as a therapy for traumatic brain injury: a review of published evidence publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19051539 contributor: fullname: Osier – volume: 5 start-page: 1147 year: 2015 ident: 10.1016/j.freeradbiomed.2021.12.007_bib85 article-title: Role of microvascular disruption in brain damage from traumatic brain injury publication-title: Comp. Physiol. doi: 10.1002/cphy.c140057 contributor: fullname: Logsdon – volume: 12 start-page: 12380 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib71 article-title: Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics publication-title: ACS Nano doi: 10.1021/acsnano.8b06399 contributor: fullname: Wang – volume: 54 start-page: 253 year: 2009 ident: 10.1016/j.freeradbiomed.2021.12.007_bib38 article-title: A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2008.12.002 contributor: fullname: Nakagawa – volume: 302 start-page: 22 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib16 article-title: CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2017.12.015 contributor: fullname: Zhao – volume: 23 start-page: 4900 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib56 article-title: Molecular mechanisms of ferroptosis and its role in cancer therapy publication-title: J. Cell Mol. Med. doi: 10.1111/jcmm.14511 contributor: fullname: Xu – volume: 1 start-page: 210 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib62 article-title: Golgi stress mediates redox imbalance and ferroptosis in human cells publication-title: Commun Biol doi: 10.1038/s42003-018-0212-6 contributor: fullname: Alborzinia – volume: 132 start-page: 111 year: 1987 ident: 10.1016/j.freeradbiomed.2021.12.007_bib39 article-title: Molecular sieving characteristics of the cultured endothelial monolayer publication-title: J. Cell. Physiol. doi: 10.1002/jcp.1041320115 contributor: fullname: Siflinger-Birnboim – volume: 17 start-page: 689 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib15 article-title: Oxidative stress: major threat in traumatic brain injury publication-title: CNS Neurol. Disord. - Drug Targets doi: 10.2174/1871527317666180627120501 contributor: fullname: Khatri – volume: 20 start-page: 675 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib20 article-title: The biogenesis, biology and characterization of circular RNAs publication-title: Nat. Rev. Genet. doi: 10.1038/s41576-019-0158-7 contributor: fullname: Kristensen – volume: 7 start-page: 6649 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib43 article-title: ApoE influences the blood-brain barrier through the NF-κB/MMP-9 pathway after traumatic brain injury publication-title: Sci. Rep. doi: 10.1038/s41598-017-06932-3 contributor: fullname: Teng – volume: 4 start-page: 461 year: 2009 ident: 10.1016/j.freeradbiomed.2021.12.007_bib81 article-title: Oxidative stress and its role in the pathogenesis of ischaemic stroke publication-title: Int. J. Stroke doi: 10.1111/j.1747-4949.2009.00387.x contributor: fullname: Allen – volume: 503 start-page: 110687 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib23 article-title: Temporal organization of pineal melatonin signaling in mammals publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2019.110687 contributor: fullname: Gorman – volume: 1173 start-page: 1 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib6 article-title: Brain iron metabolism and CNS diseases publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-981-13-9589-5_1 contributor: fullname: Thirupathi – volume: 53 start-page: 173 year: 2015 ident: 10.1016/j.freeradbiomed.2021.12.007_bib65 article-title: Biopathology of astrocytes in human traumatic and complicated brain injuries. Review and hypothesis publication-title: Folia Neuropathol. doi: 10.5114/fn.2015.54419 contributor: fullname: Castejón – volume: 93 start-page: 681 year: 2013 ident: 10.1016/j.freeradbiomed.2021.12.007_bib94 article-title: About sleep's role in memory publication-title: Physiol. Rev. doi: 10.1152/physrev.00032.2012 contributor: fullname: Rasch – volume: 9 start-page: 357 year: 2012 ident: 10.1016/j.freeradbiomed.2021.12.007_bib29 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 contributor: fullname: Langmead – volume: 19 start-page: 39 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib58 article-title: The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression publication-title: Mol. Cancer doi: 10.1186/s12943-020-01157-x contributor: fullname: Wu – volume: 12 start-page: 357 year: 2015 ident: 10.1016/j.freeradbiomed.2021.12.007_bib28 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods doi: 10.1038/nmeth.3317 contributor: fullname: Kim – volume: 73 start-page: 354 year: 2019 ident: 10.1016/j.freeradbiomed.2021.12.007_bib61 article-title: Role of mitochondria in ferroptosis publication-title: Mol. Cell doi: 10.1016/j.molcel.2018.10.042 contributor: fullname: Gao – volume: 11 year: 2016 ident: 10.1016/j.freeradbiomed.2021.12.007_bib80 article-title: Melatonin preserves blood-brain barrier integrity and permeability via matrix metalloproteinase-9 inhibition publication-title: PLoS One doi: 10.1371/journal.pone.0154427 contributor: fullname: Alluri – volume: 23 start-page: 270 year: 2016 ident: 10.1016/j.freeradbiomed.2021.12.007_bib63 article-title: Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation publication-title: Cell Death Differ. doi: 10.1038/cdd.2015.93 contributor: fullname: Hayano – volume: 12 start-page: 21687 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib47 article-title: Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury publication-title: Aging (Albany NY) doi: 10.18632/aging.103975 contributor: fullname: Li – volume: 14 start-page: 1028 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib21 article-title: CircRNAs in the brain publication-title: RNA Biol. doi: 10.1080/15476286.2016.1255398 contributor: fullname: Hanan – volume: 32 start-page: 101518 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib69 article-title: Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments publication-title: Redox Biol doi: 10.1016/j.redox.2020.101518 contributor: fullname: Stolwijk – volume: 38 start-page: 1255 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib76 article-title: Brain endothelial cell junctions after cerebral hemorrhage: changes, mechanisms and therapeutic targets publication-title: J. Cerebr. Blood Flow Metabol. doi: 10.1177/0271678X18774666 contributor: fullname: Keep – volume: 66 start-page: 108 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib74 article-title: SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling publication-title: Glia doi: 10.1002/glia.23231 contributor: fullname: Stokum – start-page: 9067610 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib26 article-title: Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in type 2 diabetic osteoporosis publication-title: Oxid Med Cell Longev contributor: fullname: Ma – start-page: 209596 year: 2009 ident: 10.1016/j.freeradbiomed.2021.12.007_bib13 article-title: 5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice publication-title: Neural Plast. contributor: fullname: Dzitoyeva – volume: 37 start-page: 2424 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib54 article-title: Multi-dimensional mapping of brain-derived extracellular vesicle MicroRNA biomarker for traumatic brain injury diagnostics publication-title: J. Neurotrauma doi: 10.1089/neu.2018.6220 contributor: fullname: Ko – volume: 95 start-page: 1246 year: 2017 ident: 10.1016/j.freeradbiomed.2021.12.007_bib3 article-title: Neuroimmunology of traumatic brain injury: time for a paradigm shift publication-title: Neuron doi: 10.1016/j.neuron.2017.07.010 contributor: fullname: Jassam – volume: 124 start-page: 493 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib49 article-title: Oxidized phospholipid signaling in traumatic brain injury publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2018.06.031 contributor: fullname: Anthonymuthu – volume: 153 start-page: 710 year: 2020 ident: 10.1016/j.freeradbiomed.2021.12.007_bib44 article-title: microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury publication-title: J. Neurochem. doi: 10.1111/jnc.14963 contributor: fullname: Wu – volume: 42 start-page: D92 year: 2014 ident: 10.1016/j.freeradbiomed.2021.12.007_bib33 article-title: starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt1248 contributor: fullname: Li – volume: 40 start-page: 382 year: 2018 ident: 10.1016/j.freeradbiomed.2021.12.007_bib11 article-title: Ferroptosis and brain injury publication-title: Dev. Neurosci. doi: 10.1159/000496922 contributor: fullname: Magtanong |
SSID | ssj0004538 |
Score | 2.624149 |
Snippet | Traumatic brain injury (TBI) can lead to disability or devastating consequences with few established treatments. Although ferroptosis has been shown to be... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 271 |
SubjectTerms | Animals Arachidonate 5-Lipoxygenase - metabolism Blood-brain barrier Brain Injuries, Traumatic - drug therapy Brain Injuries, Traumatic - genetics circRNA Endoplasmic Reticulum Stress Ferroptosis Melatonin Melatonin - pharmacology Mice microRNA MicroRNAs - metabolism RNA, Circular - metabolism Traumatic brain injury |
Title | A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury |
URI | https://dx.doi.org/10.1016/j.freeradbiomed.2021.12.007 https://www.ncbi.nlm.nih.gov/pubmed/34883251 https://search.proquest.com/docview/2608535179 |
Volume | 178 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELbarUBcELQ8lkdlBOJm8rDjZC9Iq4pqeRUEVNqbFTsTKVXjRNlspV74SfxGxk5SqAQSEsdEcWJlxjOfx_PNEPICdSAWXEgWpxqYgCRjmc6BmRTQ-5SABtIRhT-eyNWpeLdO1jvkaOLCuLTK0fYPNt1b6_FOMP7NoK2q4GuYLSJ0n4vY1adJMr5L9tAdCTEje8u371cnvxUN9w2t3fPMDbhJnv9K8yo7AHdq7cnuuF-MIx8edO1l_-yo_gZEvUM6vkNuj0iSLofJ3iU7YPfJwdLiLrq-pC-pz-30QfN9cmNoOXl5QH4sqW0u4JzW4Di_1aamY_sEWkLXNW3fbKoNzW1BwRZNi-C6rgz1XEcXKKQDuYReVDlF7EhN1ZnPfWsjEdTVF5exz5I2SNiHT2vqckNyR3enlcXvnePMbGWZJ6sg0KVXSe60KfEi3_rysVS7rhU45AzFfY-cHr_5drRiY88GZgSXPTOFRsADSYmLHdEBN2mYotglDzMjQ1ftKC2NASlNsUBoJriOpIRUQhYWgK6S3ycz21h4SKiWkdZliUZF4y4wRkuTQYwIBmJe8izncyImAal2KM2hppy1M3VNrsrJVUWxQrnOyetJmOqapil0Iv_2gmeTCihci-6AJbfQbDcK94aIflzRszl5MOjG1cw4zp8jmHz0v59_TG7FjoLhw0BPyKzvtvAUgVGvD8nuq-_R4aj-PwGLlQ-x |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEF_qFT9eRFur5-eK4tuSZDfZ5F6Eo1iu9nqKtnBvS7KZQEqzCblcof-Uf6Ozm6RaUBB8TMgmQ2Z35je785sh5D3OAR6KUDIeZ8BCiBKWZCkwHQN6nwLQQFqi8OlKLs7Dz-tovUMORy6MTascbH9v0521Hu54w9_0mrL0vvvJLED3OeO2Pk2UiDtkN4zigE_I7vz4ZLH6rWi4a2htn2d2wD3y7leaV9EC2FNrR3bHeJEHbnvQtpf9s6P6GxB1DunoEXk4IEk674V9THbA7JH9ucEourqmH6jL7XSb5nvkbt9y8nqf_JhTU1_BJa3Acn7LTUWH9gm0gLatm67elBuampyCyesGwXVVauq4jnajkPbkEnpVphSxI9Vlq792jQlCryq_2Yx9FjVexJZf1tTmhqSW7k5Lg9-7RMlMaZgjqyDQpTdJ7rQu8CLduvKxNLNdK3DIBar7CTk_-nR2uGBDzwamQyE7pvMMAQ9EBS52RAdCx36MapfCT7T0bbWjuNAapNT5DKFZKLJASoglJH4O6CrFAZmY2sAzQjMZZFlRoFHJMArkaGkS4IhggItCJKmYknBUkGr60hxqzFm7ULf0qqxeVcAV6nVKPo7KVLdmmkIn8m8veDtOAYVr0R6wpAbq7UZhbIjoxxY9m5Kn_dy4kUyg_ALB5PP__fwbcn9xdrpUy-PVyQvygFs6htsSekkmXbuFVwiSuuz1sAh-Ag9JEaE |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+novel+mechanism+linking+ferroptosis+and+endoplasmic+reticulum+stress+via+the+circPtpn14%2FmiR-351-5p%2F5-LOX+signaling+in+melatonin-mediated+treatment+of+traumatic+brain+injury&rft.jtitle=Free+radical+biology+%26+medicine&rft.au=Wu%2C+Chenrui&rft.au=Du%2C+Mengran&rft.au=Yu%2C+Renqiang&rft.au=Cheng%2C+Yuqi&rft.date=2022-01-01&rft.pub=Elsevier+Inc&rft.issn=0891-5849&rft.eissn=1873-4596&rft.volume=178&rft.spage=271&rft.epage=294&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2021.12.007&rft.externalDocID=S0891584921008583 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0891-5849&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0891-5849&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0891-5849&client=summon |