Molecular mechanisms of the anti-obesity effect of bioactive ingredients in common spices: a review

• Published in: Food & function Vol. 9; no. 9; pp. 4569 - 4581
• Main Authors: Lu, Muwen, Cao, Yong, Xiao, Jie, Song, Mingyue, Ho, Chi-Tang
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 19.09.2018
• Subjects: acyl coenzyme A; Adipocytes; Adipocytes - drug effects; Adipocytes - metabolism; Adipose tissue; adverse effects; Animal models; Animals; Anti-Obesity Agents - administration & dosage; Anti-Obesity Agents - chemistry; Apoptosis; Bioactive compounds; Biological activity; Body weight; body weight changes; Body weight gain; Body weight loss; Cell culture; Cinnamon; Dietary supplements; Fatty-acid synthase; functional foods; Functional foods & nutraceuticals; Garlic; Ginger; Glycerol; Glycerol-3-phosphate; Glycerol-3-phosphate dehydrogenase; heat production; Humans; Ingredients; lipids; Lipogenesis; metabolic diseases; Metabolic disorders; Molecular modelling; Obesity; Obesity - genetics; Obesity - metabolism; Obesity - prevention & control; onions; oral administration; Overweight; pepper; peroxisome proliferator-activated receptor gamma; Plant Extracts - administration & dosage; Plant Extracts - chemistry; PPAR gamma - genetics; PPAR gamma - metabolism; Proteins; Rosemary; saffron; Side effects; Spices; Spices - analysis; Thermogenesis; Thermogenesis - drug effects; Transcription factors; turmeric; weight loss

Obesity is a health concern related to many metabolic disorders. In the prevention and treatment of overweight, medicines and bariatric surgeries are major strategies but there are side effects. A variety of naturally occurring bioactive ingredients derived from common spices, including cinnamon, ro...