Integrative analysis of gene expression profiles of substantia nigra identifies potential diagnosis biomarkers in Parkinson's disease

• Published in: Scientific reports Vol. 14; no. 1; p. 2167
• Main Authors: Huang, Junming, Li, Bowen, Wei, Huangwei, Li, Chengxin, Liu, Chao, Mi, Hua, Chen, Shaohua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208; 631/250; 631/378; Biomarkers; Biosynthesis; Diagnosis; Dopamine receptors; Gene expression; Humanities and Social Sciences; Infiltration; Lewy bodies; Movement disorders; multidisciplinary; Nerve conduction; Neurodegeneration; Neurodegenerative diseases; Parkinson's disease; Peripheral blood; Plasma cells; Regression analysis; Science; Science (multidisciplinary); Substantia nigra

Parkinson's disease (PD) is a progressive neurodegenerative disease whose etiology is attributed to development of Lewy bodies and degeneration of dopaminergic neurons in the substantia nigra (SN). Currently, there are no definitive diagnostic indicators for PD. In this study, we aimed to ident...