Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26

• Published in: Emerging microbes & infections Vol. 9; no. 1; pp. 601 - 604
• Main Authors: Vankadari, Naveen, Wilce, Jacqueline A.
• Format: Journal Article
• Language: English
• Published: London Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: CD26; Coronavirus; Coronaviruses; COVID-19; docking; DPP4; Glycoproteins; glycosylation; Letter; Ligands; spike glycoprotein

The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is...