Transforming Growth Factor-β Signaling in Immunity and Cancer

• Published in: Immunity (Cambridge, Mass.) Vol. 50; no. 4; pp. 924 - 940
• Main Authors: Batlle, Eduard, Massagué, Joan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.04.2019; Elsevier Limited
• Subjects: Adaptive Immunity; Animals; Antigens; Apoptosis; Breast cancer; Cancer; Cancer immunotherapy; Colorectal cancer; Cytokines; Dendritic Cells - immunology; Disease Progression; Epithelial-Mesenchymal Transition; Fibroblasts - immunology; Gastric cancer; Growth factors; Homeostasis; Humans; Immune system; Immunity; Immunity, Innate; Immunoglobulins; Immunological tolerance; Immunotherapy; Inflammation; Inflammatory diseases; Kidney cancer; Kinases; Laboratories; Ligands; Macrophages - immunology; Medical research; Melanoma; Metastasis; Mice, Knockout; Mutation; Neoplasms - immunology; Neutrophils - immunology; Pancreatic cancer; Prostate cancer; Proteins; Radiation therapy; Receptors, Transforming Growth Factor beta - physiology; Signal transduction; Signal Transduction - immunology; Signaling; T-Lymphocyte Subsets - immunology; Transforming Growth Factor beta - immunology; Transforming Growth Factor beta - physiology; Transforming growth factor-b; Tumor Escape; Tumor Microenvironment; Tumors; United States > US

Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune su...