Transforming Growth Factor-β Signaling in Immunity and Cancer

Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune su...

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Published in	Immunity (Cambridge, Mass.) Vol. 50; no. 4; pp. 924 - 940
Main Authors	Batlle, Eduard, Massagué, Joan
Format	Journal Article
Language	English
Published	United States Elsevier Inc 16.04.2019 Elsevier Limited
Subjects	Adaptive Immunity Animals Antigens Apoptosis Breast cancer Cancer Cancer immunotherapy Colorectal cancer Cytokines Dendritic Cells - immunology Disease Progression Epithelial-Mesenchymal Transition Fibroblasts - immunology Gastric cancer Growth factors Homeostasis Humans Immune system Immunity Immunity, Innate Immunoglobulins Immunological tolerance Immunotherapy Inflammation Inflammatory diseases Kidney cancer Kinases Laboratories Ligands Macrophages - immunology Medical research Melanoma Metastasis Mice, Knockout Mutation Neoplasms - immunology Neutrophils - immunology Pancreatic cancer Prostate cancer Proteins Radiation therapy Receptors, Transforming Growth Factor beta - physiology Signal transduction Signal Transduction - immunology Signaling T-Lymphocyte Subsets - immunology Transforming Growth Factor beta - immunology Transforming Growth Factor beta - physiology Transforming growth factor-b Tumor Escape Tumor Microenvironment Tumors United States > US
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Abstract	Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here, we present an overview of the complex biology of the TGF-β family and its context-dependent nature. Then, focusing on cancer, we discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor. Massagué and Batlle present an overview of the complex biology of the TGF-β family and, focusing on cancer, discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged in the clinic.
AbstractList	Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here, we present an overview of the complex biology of the TGF-β family and its context-dependent nature. Then, focusing on cancer, we discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor. Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here, we present an overview of the complex biology of the TGF-β family and its context-dependent nature. Then, focusing on cancer, we discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor. Massagué and Batlle present an overview of the complex biology of the TGF-β family and, focusing on cancer, discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged in the clinic. Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here, we present an overview of the complex biology of the TGF-β family and its context-dependent nature. Then, focusing on cancer, we discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor.Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here, we present an overview of the complex biology of the TGF-β family and its context-dependent nature. Then, focusing on cancer, we discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor. Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here, we present an overview of the complex biology of the TGF-β family and its context-dependent nature. Then, focusing on cancer, we discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor.
Author	Massagué, Joan Batlle, Eduard
Author_xml	– sequence: 1 givenname: Eduard surname: Batlle fullname: Batlle, Eduard email: eduard.batlle@irbbarcelona.org organization: Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain – sequence: 2 givenname: Joan surname: Massagué fullname: Massagué, Joan email: j-massague@ski.mskcc.org organization: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30995507$$D View this record in MEDLINE/PubMed
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SubjectTerms	Adaptive Immunity Animals Antigens Apoptosis Breast cancer Cancer Cancer immunotherapy Colorectal cancer Cytokines Dendritic Cells - immunology Disease Progression Epithelial-Mesenchymal Transition Fibroblasts - immunology Gastric cancer Growth factors Homeostasis Humans Immune system Immunity Immunity, Innate Immunoglobulins Immunological tolerance Immunotherapy Inflammation Inflammatory diseases Kidney cancer Kinases Laboratories Ligands Macrophages - immunology Medical research Melanoma Metastasis Mice, Knockout Mutation Neoplasms - immunology Neutrophils - immunology Pancreatic cancer Prostate cancer Proteins Radiation therapy Receptors, Transforming Growth Factor beta - physiology Signal transduction Signal Transduction - immunology Signaling T-Lymphocyte Subsets - immunology Transforming Growth Factor beta - immunology Transforming Growth Factor beta - physiology Transforming growth factor-b Tumor Escape Tumor Microenvironment Tumors
Title	Transforming Growth Factor-β Signaling in Immunity and Cancer
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