Endosomal pH is an evolutionarily conserved driver of phenotypic plasticity in colorectal cancer

• Published in: NPJ systems biology and applications Vol. 10; no. 1; pp. 149 - 12
• Main Authors: Prasad, Hari, BV, Harshavardhan, Subbalakshmi, Ayalur Raghu, Mandal, Susmita, Jolly, Mohit Kumar, Visweswariah, Sandhya S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.12.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/67; Bioinformatics; Biomedical and Life Sciences; Calcium signalling; Cancer; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell Movement - physiology; Cell proliferation; Cell survival; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Ectopic expression; Endosomes - metabolism; Epithelial-Mesenchymal Transition - genetics; Gene Expression Regulation, Neoplastic - genetics; Humans; Hydrogen-Ion Concentration; Hypoxia; Life Sciences; Metastases; Metastasis; Na+/H+-exchanging ATPase; pH effects; Phenotype; Phenotypes; Phenotypic plasticity; Sequence analysis; Sodium-Hydrogen Exchangers - genetics; Sodium-Hydrogen Exchangers - metabolism; Systems Biology; Therapeutic targets

Dysregulated pH is now recognised as a hallmark of cancer. Recent evidence has revealed that the endosomal pH regulator Na + /H + exchanger NHE9 is upregulated in colorectal cancer to impose a pseudo-starvation state associated with invasion, highlighting an underexplored mechanistic link between ad...