Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats
It is unknown whether androstenedione, a steroidal dietary supplement taken to enhance athletic performance, can affect physiological hormone levels by altering liver enzyme activities that metabolize steroid hormones. Altered hormone levels could be especially devastating during pregnancy. Mature f...
Saved in:
| Published in | Food and chemical toxicology Vol. 43; no. 4; pp. 537 - 542 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Ltd
01.04.2005
New York, NY Elsevier Science |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | It is unknown whether androstenedione, a steroidal dietary supplement taken to enhance athletic performance, can affect physiological hormone levels by altering liver enzyme activities that metabolize steroid hormones. Altered hormone levels could be especially devastating during pregnancy. Mature female rats were gavaged with 0, 5, 30 or 60
mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60
mg/kg/day androstenedione. Livers were removed from dams on gestation day 20 and from non-pregnant rats after five weeks’ treatment. Liver microsomes were incubated with 200
μM testosterone, and the reaction products were isolated and analyzed by HPLC. In pregnant rats, formation of 6α-, 15β-, 7α-, 16β-, and 2β-hydroxytestosterone was increased significantly vs. control at the highest dose level only. Formation of 6β-hydroxytestosterone increased significantly at both the 30 and 60
mg/kg/day dose levels. In non-pregnant rats, 60
mg/kg/day androstenedione significantly increased formation of 15β-, 6β-, 16β-, and 2β-hydroxytestosterone. The data suggest that high oral doses of androstenedione can induce some female rat liver cytochromes P450 that metabolize steroid hormones and that the response to androstenedione does not differ between pregnant and non-pregnant female rats. |
|---|---|
| AbstractList | It is unknown whether androstenedione, a steroidal dietary supplement taken to enhance athletic performance, can affect physiological hormone levels by altering liver enzyme activities that metabolize steroid hormones. Altered hormone levels could be especially devastating during pregnancy. Mature female rats were gavaged with 0, 5, 30 or 60
mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60
mg/kg/day androstenedione. Livers were removed from dams on gestation day 20 and from non-pregnant rats after five weeks’ treatment. Liver microsomes were incubated with 200
μM testosterone, and the reaction products were isolated and analyzed by HPLC. In pregnant rats, formation of 6α-, 15β-, 7α-, 16β-, and 2β-hydroxytestosterone was increased significantly vs. control at the highest dose level only. Formation of 6β-hydroxytestosterone increased significantly at both the 30 and 60
mg/kg/day dose levels. In non-pregnant rats, 60
mg/kg/day androstenedione significantly increased formation of 15β-, 6β-, 16β-, and 2β-hydroxytestosterone. The data suggest that high oral doses of androstenedione can induce some female rat liver cytochromes P450 that metabolize steroid hormones and that the response to androstenedione does not differ between pregnant and non-pregnant female rats. It is unknown whether androstenedione, a steroidal dietary supplement taken to enhance athletic performance, can affect physiological hormone levels by altering liver enzyme activities that metabolize steroid hormones. Altered hormone levels could be especially devastating during pregnancy. Mature female rats were gavaged with 0, 5, 30 or 60 mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60 mg/kg/day androstenedione. Livers were removed from dams on gestation day 20 and from non- pregnant rats after five weeks' treatment. Liver microsomes were incubated with 200 mu M testosterone, and the reaction products were isolated and analyzed by HPLC. In pregnant rats, formation of 6 alpha -, 15 beta -, 7 alpha -, 16 beta -, and 2 beta -hydroxytestosterone was increased significantly vs. control at the highest dose level only. Formation of 6 beta -hydroxytestosterone increased significantly at both the 30 and 60 mg/kg/day dose levels. In non-pregnant rats, 60 mg/kg/day androstenedione significantly increased formation of 15 beta -, 6 beta -, 16 beta -, and 2 beta -hydroxytestosterone. The data suggest that high oral doses of androstenedione can induce some female rat liver cytochromes P450 that metabolize steroid hormones and that the response to androstenedione does not differ between pregnant and non-pregnant female rats. It is unknown whether androstenedione, a steroidal dietary supplement taken to enhance athletic performance, can affect physiological hormone levels by altering liver enzyme activities that metabolize steroid hormones. Altered hormone levels could be especially devastating during pregnancy. Mature female rats were gavaged with 0, 5, 30 or 60 mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60 mg/kg/day androstenedione. Livers were removed from dams on gestation day 20 and from non-pregnant rats after five weeks' treatment. Liver microsomes were incubated with 200 microM testosterone, and the reaction products were isolated and analyzed by HPLC. In pregnant rats, formation of 6alpha-, 15beta-, 7alpha-, 16beta-, and 2beta-hydroxytestosterone was increased significantly vs. control at the highest dose level only. Formation of 6beta-hydroxytestosterone increased significantly at both the 30 and 60 mg/kg/day dose levels. In non-pregnant rats, 60 mg/kg/day androstenedione significantly increased formation of 15beta-, 6beta-, 16beta-, and 2beta-hydroxytestosterone. The data suggest that high oral doses of androstenedione can induce some female rat liver cytochromes P450 that metabolize steroid hormones and that the response to androstenedione does not differ between pregnant and non-pregnant female rats. |
| Author | Sahu, S. Sprando, R.L. Ross, I.A. O’Donnell, M.W. Sapienza, P.P. Collins, T.F.X. Flynn, T.J. Wiesenfeld, P.W. Kim, C.S. |
| Author_xml | – sequence: 1 givenname: T.J. surname: Flynn fullname: Flynn, T.J. email: tflynn@cfsan.fda.gov organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA – sequence: 2 givenname: P.P. surname: Sapienza fullname: Sapienza, P.P. organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA – sequence: 3 givenname: P.W. surname: Wiesenfeld fullname: Wiesenfeld, P.W. organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA – sequence: 4 givenname: I.A. surname: Ross fullname: Ross, I.A. organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA – sequence: 5 givenname: S. surname: Sahu fullname: Sahu, S. organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA – sequence: 6 givenname: C.S. surname: Kim fullname: Kim, C.S. organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA – sequence: 7 givenname: M.W. surname: O’Donnell fullname: O’Donnell, M.W. organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, 8301 Muirkirk Road, Laurel, MD 20708, USA – sequence: 8 givenname: T.F.X. surname: Collins fullname: Collins, T.F.X. organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA – sequence: 9 givenname: R.L. surname: Sprando fullname: Sprando, R.L. organization: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16541680$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15721200$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkcFu1DAQhi1URLeFB-ACvtBblpk4dhJxQlULSJU4QM-W44xXXiX2Ymcr8fY42hW9wcmy9f3j0f9dsYsQAzH2FmGLgOrjfuvssq0Bmi3WW4D2Bdtg14pKCYkXbAN121WqR3nJrnLeQyGwVa_YJcq2xpLbsN2dc2SXzKPjMZmJmzCmmBcKNPryG4-Bl1uKfuQzLWaIk88z94FP_onSGjsk2gUTljXKy4bV3wdHs5mIJ7Pk1-ylM1OmN-fzmj3e3_28_Vo9fP_y7fbzQ2UboZZqUCRdL6TtobOqQTN2gwJCshJGSwZHa5UA5ahF0QgcO4HQDEMNQ29kDeKa3ZzmHlL8daS86NlnS9NkAsVj1qptGtlB_18Q2w5q2a8T8QTa0ktO5PQh-dmk3xpBrxr0XhcNetWgsdal5JJ5dx5-HGYanxPn3gvw4QyYbM3kkgnW52dOyQZVt3LvT5wzUZtdKszjjxpQAPQdFs2F-HQiqLT65CnpbD0FW_SlIlaP0f9j0T8p8bCE |
| CODEN | FCTOD7 |
| CitedBy_id | crossref_primary_10_1002_jat_1325 crossref_primary_10_3390_molecules26206210 crossref_primary_10_1016_j_steroids_2015_03_001 crossref_primary_10_5812_jjcdc_106517 crossref_primary_10_1016_j_fct_2005_09_005 |
| Cites_doi | 10.1093/toxsci/65.1.71 10.18388/abp.2000_3964 10.1006/abio.2001.5223 10.1016/0006-2952(93)90344-V 10.1124/dmd.104.000208 10.1055/s-2008-1040579 10.1016/j.fct.2004.01.015 10.1021/bi00337a023 10.1016/S0091-3057(96)00249-3 10.1055/s-2004-814201 10.1016/0006-2952(95)02041-1 10.1016/j.fct.2004.11.005 10.1016/1056-8719(94)00073-D 10.1590/S0100-879X2000000100014 10.1096/fj.02-0138com 10.1210/jc.2002-021035 10.1016/j.fct.2004.11.020 10.1016/j.cbi.2004.01.006 10.1016/S1056-8719(97)00013-0 10.1016/S0165-6147(03)00049-X 10.2165/00002018-200427110-00003 10.1007/s002040050636 10.1001/jama.281.21.2043 10.1373/49.1.167 |
| ContentType | Journal Article |
| Copyright | 2005 2005 INIST-CNRS |
| Copyright_xml | – notice: 2005 – notice: 2005 INIST-CNRS |
| DBID | FBQ IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TS 7U7 C1K 7X8 |
| DOI | 10.1016/j.fct.2004.12.007 |
| DatabaseName | AGRIS Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Physical Education Index Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Toxicology Abstracts Physical Education Index Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | Toxicology Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Economics Chemistry Public Health |
| EISSN | 1873-6351 |
| EndPage | 542 |
| ExternalDocumentID | 10_1016_j_fct_2004_12_007 15721200 16541680 US201300981635 S0278691505000050 |
| Genre | Research Support, U.S. Gov't, P.H.S Journal Article |
| GroupedDBID | --- --K --M .55 .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29H 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AABVA AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALCJ AALRI AAOAW AAQFI AAQXK AATCM AATLK AAXUO ABFNM ABFRF ABFYP ABGRD ABJNI ABLST ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADQTV AEBSH AEFWE AEKER AENEX AEQOU AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AHPSJ AI. AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC CBWCG CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLV HMT HVGLF HZ~ IHE J1W K-O KCYFY KOM LW9 M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAB SCC SDF SDG SDP SES SEW SPCBC SPT SSA SSJ SSP SSZ T5K VH1 WUQ X7M ZXP ~G- ~KM ABPIF ABPTK AEQTP FBQ 08R AAUGY IQODW AAHBH AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TS 7U7 C1K 7X8 |
| ID | FETCH-LOGICAL-c436t-b6e5f935c908c641ad8b60e1ec50dcea1dcc6306fe713431d83104bb20b9a5203 |
| IEDL.DBID | .~1 |
| ISSN | 0278-6915 |
| IngestDate | Fri Oct 25 01:45:20 EDT 2024 Fri Oct 25 00:17:58 EDT 2024 Thu Sep 26 16:48:33 EDT 2024 Sat Sep 28 07:53:00 EDT 2024 Sun Oct 22 16:04:34 EDT 2023 Wed Dec 27 19:43:37 EST 2023 Fri Feb 23 02:35:09 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Endocrine disruption Androstenedione Liver Steroids Cytochromes P450 Steroid Rat Digestive system Enzyme Cytochrome P450 Rodentia Endocrine disruptor Metabolism Pregnancy Vertebrata Mammalia Animal Female |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c436t-b6e5f935c908c641ad8b60e1ec50dcea1dcc6306fe713431d83104bb20b9a5203 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| PMID | 15721200 |
| PQID | 17802590 |
| PQPubID | 23462 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_67445809 proquest_miscellaneous_17802590 crossref_primary_10_1016_j_fct_2004_12_007 pubmed_primary_15721200 pascalfrancis_primary_16541680 fao_agris_US201300981635 elsevier_sciencedirect_doi_10_1016_j_fct_2004_12_007 |
| PublicationCentury | 2000 |
| PublicationDate | 2005-04-01 |
| PublicationDateYYYYMMDD | 2005-04-01 |
| PublicationDate_xml | – month: 04 year: 2005 text: 2005-04-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford New York, NY |
| PublicationPlace_xml | – name: Oxford – name: New York, NY – name: England |
| PublicationTitle | Food and chemical toxicology |
| PublicationTitleAlternate | Food Chem Toxicol |
| PublicationYear | 2005 |
| Publisher | Elsevier Ltd Elsevier Science |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier Science |
| References | Ishak, Zimmerman (bib8) 1987; 7 Sahu, Sapienza, Sprando, Collins, Ross, Flynn, Wiesenfeld, O’Donnell, Kim (bib17) 2005; 43 FDA, 2004. Health effects of androstenedione. FDA White Paper, March 11, 2004. Available from (bib7) 1996 You (bib27) 2004; 147 Thum, Borlak (bib22) 2002; 16 Sprando, R.L., Collins, T.F.X., Black, T.N., Olejnik, N., Ramos-Valle, M., Sapienza, P., Rorie, J., Ruggles, D.I., in press. Maternal exposure to androstenedione does not induce developmental toxicity in the rat. Food and Chemical Toxicology Waxman, Dannan, Guengerich (bib23) 1985; 24 Czekaj, Wiaderkiewicz, Florek, Wiaderkiewicz (bib4) 2000; 47 Sahi, Stern, Milad, Rose, Gibson, Zheng, Stilgenbauer, Sadagopan, Jolley, Gilbert, LeCluyse (bib16) 2004; 32 Purdon, Lehman-McKeeman (bib15) 1997; 37 Kicman, Bassindale, Cowan, Dale, Hutt, Leeds (bib9) 2003; 49 Yesalis (bib26) 1999; 281 Brown, Dewey, Brunkhorst, Vukovich, King (bib3) 2004; 36 Kim (bib10) 1995; 50 Mannel (bib13) 2004; 27 Shrier, Harvey, Sell, Filmardirossian, Erickson, Gay, Berry, Harvey (bib18) 2001; 64 Welder, Robertson, Melchert (bib24) 1995; 33 Kuriyama, De-Oliveira, Fidalgo-Neto, Paumgartten (bib11) 2000; 33 Leder, Leblanc, Longcope, Lee, Catlin, Finkelstein (bib12) 2002; 87 Boada, Zumbado, Torres, López, Díaz-Chico, Cabrera, Luzardo (bib1) 1999; 73 Sprando, Collins, Black, Olejnik, Grundel, Ruggles (bib19) 2004; 42 Borlakoglu, Scott, Henderson, Wolf (bib2) 1993; 46 Tachibana, Tanaka (bib21) 2001; 295 Ekins, Stresser, Williams (bib5) 2003; 24 Wolf, Hotchkiss, Ostby, LeBlanc, Gray (bib25) 2002; 65 McGivern, Fatayerji, Handa (bib14) 1996; 55 > McGivern (10.1016/j.fct.2004.12.007_bib14) 1996; 55 Welder (10.1016/j.fct.2004.12.007_bib24) 1995; 33 Sahi (10.1016/j.fct.2004.12.007_bib16) 2004; 32 Kim (10.1016/j.fct.2004.12.007_bib10) 1995; 50 Brown (10.1016/j.fct.2004.12.007_bib3) 2004; 36 10.1016/j.fct.2004.12.007_bib6 Purdon (10.1016/j.fct.2004.12.007_bib15) 1997; 37 Sahu (10.1016/j.fct.2004.12.007_bib17) 2005; 43 Boada (10.1016/j.fct.2004.12.007_bib1) 1999; 73 Thum (10.1016/j.fct.2004.12.007_bib22) 2002; 16 Yesalis (10.1016/j.fct.2004.12.007_bib26) 1999; 281 Borlakoglu (10.1016/j.fct.2004.12.007_bib2) 1993; 46 Waxman (10.1016/j.fct.2004.12.007_bib23) 1985; 24 Czekaj (10.1016/j.fct.2004.12.007_bib4) 2000; 47 (10.1016/j.fct.2004.12.007_bib7) 1996 Mannel (10.1016/j.fct.2004.12.007_bib13) 2004; 27 Sprando (10.1016/j.fct.2004.12.007_bib19) 2004; 42 Kicman (10.1016/j.fct.2004.12.007_bib9) 2003; 49 Kuriyama (10.1016/j.fct.2004.12.007_bib11) 2000; 33 Leder (10.1016/j.fct.2004.12.007_bib12) 2002; 87 10.1016/j.fct.2004.12.007_bib20 Ishak (10.1016/j.fct.2004.12.007_bib8) 1987; 7 Ekins (10.1016/j.fct.2004.12.007_bib5) 2003; 24 Shrier (10.1016/j.fct.2004.12.007_bib18) 2001; 64 Tachibana (10.1016/j.fct.2004.12.007_bib21) 2001; 295 You (10.1016/j.fct.2004.12.007_bib27) 2004; 147 Wolf (10.1016/j.fct.2004.12.007_bib25) 2002; 65 |
| References_xml | – volume: 36 start-page: 62 year: 2004 end-page: 66 ident: bib3 article-title: Changes in serum testosterone and estradiol concentrations following acute androstenedione ingestion in young women publication-title: Hormones and Metabolic Research contributor: fullname: King – volume: 87 start-page: 5449 year: 2002 end-page: 5454 ident: bib12 article-title: Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women publication-title: Journal of Clinical Endocrinology and Metabolism contributor: fullname: Finkelstein – volume: 33 start-page: 187 year: 1995 end-page: 195 ident: bib24 article-title: Toxic effects of anabolic–androgenic steroids in primary rat hepatic cell cultures publication-title: Journal of Pharmacological and Toxicological Methods contributor: fullname: Melchert – volume: 64 start-page: 331 year: 2001 end-page: 332 ident: bib18 article-title: Maternal and fetal estrogen levels after administration of androstenedione to pregnant rats publication-title: Biology of Reproduction contributor: fullname: Harvey – volume: 33 start-page: 103 year: 2000 end-page: 109 ident: bib11 article-title: Effects of pregnancy and protein-energy malnutrition on monooxygenase O-dealkylation activity in rat liver microsomes publication-title: Brazilian Journal of Medical and Biological Research contributor: fullname: Paumgartten – volume: 281 start-page: 2043 year: 1999 end-page: 2044 ident: bib26 article-title: Medical, legal and societal implications of androstenedione use publication-title: Journal of the American Medical Association contributor: fullname: Yesalis – volume: 49 start-page: 167 year: 2003 end-page: 169 ident: bib9 article-title: Effect of androstenedione ingestion on plasma testosterone in young women; a dietary supplement with potential health risks publication-title: Clinical Chemistry contributor: fullname: Leeds – volume: 7 start-page: 230 year: 1987 end-page: 236 ident: bib8 article-title: Hepatotoxic effects of the anabolic/androgenic steroids publication-title: Seminars in Liver Disease contributor: fullname: Zimmerman – volume: 43 start-page: 341 year: 2005 end-page: 344 ident: bib17 article-title: Hepatotoxicity of androstenedione in pregnant rats publication-title: Food and Chemical Toxicology contributor: fullname: Kim – year: 1996 ident: bib7 publication-title: Cytochromes P450—Metabolic and Toxicological Aspects – volume: 47 start-page: 1115 year: 2000 end-page: 1127 ident: bib4 article-title: Expression of cytochrome CYP2B1/2 in nonpregnant, pregnant and fetal rats exposed to tobacco smoke publication-title: Acta Biochimica Polonica contributor: fullname: Wiaderkiewicz – volume: 32 start-page: 1370 year: 2004 end-page: 1376 ident: bib16 article-title: Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo publication-title: Drug Metabolism and Disposition contributor: fullname: LeCluyse – volume: 42 start-page: 917 year: 2004 end-page: 924 ident: bib19 article-title: Effects of androstenedione on in utero development in rats publication-title: Food and Chemical Toxicology contributor: fullname: Ruggles – volume: 55 start-page: 549 year: 1996 end-page: 557 ident: bib14 article-title: Androstenedione synergizes with stress or prenatal drug exposure to retard fetal growth: role of IGF publication-title: Pharmacology Biochemistry and Behavior contributor: fullname: Handa – volume: 16 start-page: 1537 year: 2002 end-page: 1549 ident: bib22 article-title: Testosterone, cytochrome P450, and cardiac hypertrophy publication-title: FASEB Journal contributor: fullname: Borlak – volume: 65 start-page: 71 year: 2002 end-page: 86 ident: bib25 article-title: Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study publication-title: Toxicological Sciences contributor: fullname: Gray – volume: 147 start-page: 233 year: 2004 end-page: 246 ident: bib27 article-title: Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes publication-title: Chemico-Biological Interactions contributor: fullname: You – volume: 295 start-page: 248 year: 2001 end-page: 256 ident: bib21 article-title: Simultaneous determination of testosterone metabolites in liver microsomes using column-switching semi-microcolumn high-performance liquid chromatography publication-title: Analytical Biochemistry contributor: fullname: Tanaka – volume: 24 start-page: 4409 year: 1985 end-page: 4417 ident: bib23 article-title: Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes publication-title: Biochemistry contributor: fullname: Guengerich – volume: 50 start-page: 1593 year: 1995 end-page: 1597 ident: bib10 article-title: Expression of rat microsomal epoxide hydrolase during pregnancy publication-title: Biochemical Pharmacology contributor: fullname: Kim – volume: 37 start-page: 67 year: 1997 end-page: 73 ident: bib15 article-title: Improved high-performance liquid chromatographic procedure for the separation and quantification of hydroxytestosterone metabolites publication-title: Journal of Pharmacological Methods contributor: fullname: Lehman-McKeeman – volume: 73 start-page: 465 year: 1999 end-page: 472 ident: bib1 article-title: Evaluation of acute and chronic hepatotoxic effects exerted by anabolic–androgenic steroid stanozolol in adult male rats publication-title: Archives of Toxicology contributor: fullname: Luzardo – volume: 46 start-page: 29 year: 1993 end-page: 36 ident: bib2 article-title: Alterations in rat hepatic drug metabolism during pregnancy and lactation publication-title: Biochemical Pharmacology contributor: fullname: Wolf – volume: 27 start-page: 773 year: 2004 end-page: 797 ident: bib13 article-title: Drug interactions with St John’s wort: mechanisms and clinical implications publication-title: Drug Safety contributor: fullname: Mannel – volume: 24 start-page: 161 year: 2003 end-page: 166 ident: bib5 article-title: In vitro and pharmacophore insights into CYP3A enzymes publication-title: Trends in Pharmacological Sciences contributor: fullname: Williams – volume: 65 start-page: 71 year: 2002 ident: 10.1016/j.fct.2004.12.007_bib25 article-title: Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study publication-title: Toxicological Sciences doi: 10.1093/toxsci/65.1.71 contributor: fullname: Wolf – ident: 10.1016/j.fct.2004.12.007_bib6 – volume: 47 start-page: 1115 year: 2000 ident: 10.1016/j.fct.2004.12.007_bib4 article-title: Expression of cytochrome CYP2B1/2 in nonpregnant, pregnant and fetal rats exposed to tobacco smoke publication-title: Acta Biochimica Polonica doi: 10.18388/abp.2000_3964 contributor: fullname: Czekaj – volume: 295 start-page: 248 year: 2001 ident: 10.1016/j.fct.2004.12.007_bib21 article-title: Simultaneous determination of testosterone metabolites in liver microsomes using column-switching semi-microcolumn high-performance liquid chromatography publication-title: Analytical Biochemistry doi: 10.1006/abio.2001.5223 contributor: fullname: Tachibana – volume: 46 start-page: 29 year: 1993 ident: 10.1016/j.fct.2004.12.007_bib2 article-title: Alterations in rat hepatic drug metabolism during pregnancy and lactation publication-title: Biochemical Pharmacology doi: 10.1016/0006-2952(93)90344-V contributor: fullname: Borlakoglu – volume: 32 start-page: 1370 year: 2004 ident: 10.1016/j.fct.2004.12.007_bib16 article-title: Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo publication-title: Drug Metabolism and Disposition doi: 10.1124/dmd.104.000208 contributor: fullname: Sahi – volume: 7 start-page: 230 year: 1987 ident: 10.1016/j.fct.2004.12.007_bib8 article-title: Hepatotoxic effects of the anabolic/androgenic steroids publication-title: Seminars in Liver Disease doi: 10.1055/s-2008-1040579 contributor: fullname: Ishak – volume: 42 start-page: 917 year: 2004 ident: 10.1016/j.fct.2004.12.007_bib19 article-title: Effects of androstenedione on in utero development in rats publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2004.01.015 contributor: fullname: Sprando – volume: 24 start-page: 4409 year: 1985 ident: 10.1016/j.fct.2004.12.007_bib23 article-title: Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes publication-title: Biochemistry doi: 10.1021/bi00337a023 contributor: fullname: Waxman – volume: 55 start-page: 549 year: 1996 ident: 10.1016/j.fct.2004.12.007_bib14 article-title: Androstenedione synergizes with stress or prenatal drug exposure to retard fetal growth: role of IGF publication-title: Pharmacology Biochemistry and Behavior doi: 10.1016/S0091-3057(96)00249-3 contributor: fullname: McGivern – volume: 36 start-page: 62 year: 2004 ident: 10.1016/j.fct.2004.12.007_bib3 article-title: Changes in serum testosterone and estradiol concentrations following acute androstenedione ingestion in young women publication-title: Hormones and Metabolic Research doi: 10.1055/s-2004-814201 contributor: fullname: Brown – volume: 50 start-page: 1593 year: 1995 ident: 10.1016/j.fct.2004.12.007_bib10 article-title: Expression of rat microsomal epoxide hydrolase during pregnancy publication-title: Biochemical Pharmacology doi: 10.1016/0006-2952(95)02041-1 contributor: fullname: Kim – year: 1996 ident: 10.1016/j.fct.2004.12.007_bib7 – volume: 43 start-page: 341 year: 2005 ident: 10.1016/j.fct.2004.12.007_bib17 article-title: Hepatotoxicity of androstenedione in pregnant rats publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2004.11.005 contributor: fullname: Sahu – volume: 33 start-page: 187 year: 1995 ident: 10.1016/j.fct.2004.12.007_bib24 article-title: Toxic effects of anabolic–androgenic steroids in primary rat hepatic cell cultures publication-title: Journal of Pharmacological and Toxicological Methods doi: 10.1016/1056-8719(94)00073-D contributor: fullname: Welder – volume: 33 start-page: 103 year: 2000 ident: 10.1016/j.fct.2004.12.007_bib11 article-title: Effects of pregnancy and protein-energy malnutrition on monooxygenase O-dealkylation activity in rat liver microsomes publication-title: Brazilian Journal of Medical and Biological Research doi: 10.1590/S0100-879X2000000100014 contributor: fullname: Kuriyama – volume: 16 start-page: 1537 year: 2002 ident: 10.1016/j.fct.2004.12.007_bib22 article-title: Testosterone, cytochrome P450, and cardiac hypertrophy publication-title: FASEB Journal doi: 10.1096/fj.02-0138com contributor: fullname: Thum – volume: 87 start-page: 5449 year: 2002 ident: 10.1016/j.fct.2004.12.007_bib12 article-title: Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women publication-title: Journal of Clinical Endocrinology and Metabolism doi: 10.1210/jc.2002-021035 contributor: fullname: Leder – ident: 10.1016/j.fct.2004.12.007_bib20 doi: 10.1016/j.fct.2004.11.020 – volume: 147 start-page: 233 year: 2004 ident: 10.1016/j.fct.2004.12.007_bib27 article-title: Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes publication-title: Chemico-Biological Interactions doi: 10.1016/j.cbi.2004.01.006 contributor: fullname: You – volume: 64 start-page: 331 issue: Suppl. 1 year: 2001 ident: 10.1016/j.fct.2004.12.007_bib18 article-title: Maternal and fetal estrogen levels after administration of androstenedione to pregnant rats publication-title: Biology of Reproduction contributor: fullname: Shrier – volume: 37 start-page: 67 year: 1997 ident: 10.1016/j.fct.2004.12.007_bib15 article-title: Improved high-performance liquid chromatographic procedure for the separation and quantification of hydroxytestosterone metabolites publication-title: Journal of Pharmacological Methods doi: 10.1016/S1056-8719(97)00013-0 contributor: fullname: Purdon – volume: 24 start-page: 161 year: 2003 ident: 10.1016/j.fct.2004.12.007_bib5 article-title: In vitro and pharmacophore insights into CYP3A enzymes publication-title: Trends in Pharmacological Sciences doi: 10.1016/S0165-6147(03)00049-X contributor: fullname: Ekins – volume: 27 start-page: 773 year: 2004 ident: 10.1016/j.fct.2004.12.007_bib13 article-title: Drug interactions with St John’s wort: mechanisms and clinical implications publication-title: Drug Safety doi: 10.2165/00002018-200427110-00003 contributor: fullname: Mannel – volume: 73 start-page: 465 year: 1999 ident: 10.1016/j.fct.2004.12.007_bib1 article-title: Evaluation of acute and chronic hepatotoxic effects exerted by anabolic–androgenic steroid stanozolol in adult male rats publication-title: Archives of Toxicology doi: 10.1007/s002040050636 contributor: fullname: Boada – volume: 281 start-page: 2043 year: 1999 ident: 10.1016/j.fct.2004.12.007_bib26 article-title: Medical, legal and societal implications of androstenedione use publication-title: Journal of the American Medical Association doi: 10.1001/jama.281.21.2043 contributor: fullname: Yesalis – volume: 49 start-page: 167 year: 2003 ident: 10.1016/j.fct.2004.12.007_bib9 article-title: Effect of androstenedione ingestion on plasma testosterone in young women; a dietary supplement with potential health risks publication-title: Clinical Chemistry doi: 10.1373/49.1.167 contributor: fullname: Kicman |
| SSID | ssj0007176 |
| Score | 1.8201554 |
| Snippet | It is unknown whether androstenedione, a steroidal dietary supplement taken to enhance athletic performance, can affect physiological hormone levels by... |
| SourceID | proquest crossref pubmed pascalfrancis fao elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 537 |
| SubjectTerms | Administration, Oral adverse effects Androstenedione Androstenedione - administration & dosage Androstenedione - pharmacology Animals Biological and medical sciences cytochrome P-450 Cytochrome P-450 Enzyme System - pharmacology Cytochromes P450 dosage Endocrine disruption endocrine-disrupting chemicals ergogenic aids Female gestational age hepatotoxicity hormone metabolism hormone supplements Liver Liver - drug effects Liver - physiology liver microsomes maternal nutrition Medical sciences nutrient-drug interactions Pregnancy pregnancy outcome pregnant women Rats Steroids Steroids - metabolism Toxicology |
| Title | Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats |
| URI | https://dx.doi.org/10.1016/j.fct.2004.12.007 https://www.ncbi.nlm.nih.gov/pubmed/15721200 https://search.proquest.com/docview/17802590 https://search.proquest.com/docview/67445809 |
| Volume | 43 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VcgAJVVAeTYHFB05IYZ3E9jrHakW1gOilrNSb5Tj2aqtusmq2V347M07CqhL0wC2K7MTxTObh-WYG4KMMAbVeOUsrXfBUBFvjFQHXvLOl5TaznnKHf1yoxVJ8u5JXBzAfc2EIVjnI_l6mR2k93JkOuzndrtfTS4qZqRINGqrpz6PfLlD9IU9__rWHeaC7EuOVODil0WNkM2K8gotwShFPBKmj7N9106NgWwJN2g73LfQNL_5tkUbNdP4cjgaTkp31q34BB745hifzsZMbXo_Zx90xPOvP6ViffvQSVn354o61gVGyPrNUwQBJj-KXihixtmFUS6Fd12zjd8gyN-tuw9YNuyFEB03b3voVwWloKmvaJv1zI_gN6h-GTNa9guX5l5_zRTo0X0idKNQurZSXoSykK7l2SmS21pXiPvNO8tp5m9XOKfQ3gqds1CKrqWOZqKqcV6WVOS9ewyG-0p8AywJ6aVo4bRXaD9bquipkXUvrQ55ZpxL4NG672fY1NswIPrs2SCPqlSlMlhukUQJiJIy5xygGdcBD006QiMauUHSa5WVOAVtearRGZQKTe5Tdr4F6pCvNE_gwktog5SiiYhvf3nUmm2m0GcsHRqiZEFLzMoE3PY_sny7R-cYVnv7fB72Fp7GKbAQRvYPD3e2df4_20a6axB9gAo_Pvn5fXPwGAEYNVg |
| link.rule.ids | 315,783,787,4509,24128,27936,27937,45597,45691 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYoHKhUVS19kD7Ah54qReskttc-olXRUmAvsBI3y_FjFcQmK7L8_87kAUJqOfQWWXbieOx5eL6ZIeSHiBGknp6mpSpYyqP18ITAteCstsxmNmDs8OVCzpf894242SGzMRYGYZUD7-95eseth5bJsJqTTVVNrtBnJjUoNJjTn6HdvgfagIbTuXdydj5fPDJksFg6lyX0T3HA6NzsYF7RdYhK3l0KYlHZv4unV9E2iJu0LSxd7Gte_Fsp7YTT6TvydtAq6Uk_8fdkJ9QHZH82FnOD5zEAuT0gb_qrOtpHIH0gqz6DcUubSDFen1pMYgDUBw6MeYxoU1NMp9BUnq7DFnbNXdWuaVXTOwR14LDNfVghogaH0rqp08eGGNYggijss_YjWZ7-up7N06H-Qup4IbdpKYOIuhBOM-Ukz6xXpWQhC04w74LNvHMSTI4YMCC1yDwWLeNlmbNSW5Gz4hPZhU-GQ0KzCIaa4k5ZCSqEtcqXhfBe2BDzzDqZkJ_jsptNn2bDjPizWwM0wnKZ3GS5ARolhI-EMc_2igEx8NKwQyCisSvgnmZ5laPPlmkFCqlIyNEzyj7NAcukS8UScjyS2gDl0Kli69A8tCabKlAb9Qs95JRzoZhOyOd-jzy9XYD9DTP88n8_dEz259eXF-bibHH-lbzuksp2mKJvZHd7_xC-g7q0LY-G4_AHP1UQCg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+oral+androstenedione+on+steroid+metabolism+in+liver+of+pregnant+and+non-pregnant+female+rats&rft.jtitle=Food+and+chemical+toxicology&rft.au=Flynn%2C+T+J&rft.au=Sapienza%2C+P+P&rft.au=Wiesenfeld%2C+P+W&rft.au=Ross%2C+IA&rft.date=2005-04-01&rft.issn=0278-6915&rft.volume=43&rft.issue=4&rft.spage=537&rft.epage=542&rft_id=info:doi/10.1016%2Fj.fct.2004.12.007&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0278-6915&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0278-6915&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0278-6915&client=summon |