The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors

• Published in: Molecular biology of the cell Vol. 8; no. 7; pp. 1317 - 1327
• Main Authors: Givan, S A, Sprague, G F
• Format: Journal Article
• Language: English
• Published: United States 01.07.1997
• Subjects: Acyltransferases; Ankyrin Repeat - genetics; Ankyrins - genetics; Ankyrins - physiology; Chemoreceptor Cells - metabolism; Chemoreceptor Cells - physiology; Chemotactic Factors - metabolism; Endocytosis - genetics; Endocytosis - physiology; Fungal Proteins - genetics; Fungal Proteins - physiology; Membrane Proteins - metabolism; Mutation; Pheromones - physiology; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Receptors, Cell Surface - physiology; Receptors, G-Protein-Coupled; Receptors, Mating Factor; Receptors, Peptide - metabolism; Receptors, Peptide - physiology; Receptors, Pheromone; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors

The Saccharomyces cerevisiae a-factor receptor (Ste3p) requires its C-terminal cytoplasmic tail for endocytosis. Wild-type receptor is delivered to the cell surface via the secretory pathway but remains there only briefly before being internalized and delivered to the vacuole for degradation. Recept...