SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma - Choe, Joseph H; Watchmaker, Payal B; Simic, Milos S; Gilbert, Ryan D; Li, Aileen W; Krasnow, Nira A; Downey, Kira M; Yu, Wei; Carrera, Diego A; Celli, Anna; Cho, Juhyun; Briones, Jessica D; et al. (Science translational medicine, 2021)
Keywords: Animals; Brain - metabolism; Brain Neoplasms - therapy; Cell Line, Tumor; Glioblastoma - therapy; Immunotherapy, Adoptive; Mice; Receptors, Antigen, T-Cell - metabolism; T-Lymphocytes - metabolism; Xenograft Model Antitumor Assays