Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study

• Published in: Critical care (London, England) Vol. 18; no. 4; p. R156
• Main Authors: Tanaka, Lilian Maria Sobreira, Azevedo, Luciano Cesar Pontes, Park, Marcelo, Schettino, Guilherme, Nassar, Antonio Paulo, Réa-Neto, Alvaro, Tannous, Luana, de Souza-Dantas, Vicente Ces, Torelly, André, Lisboa, Thiago, Piras, Claudio, Carvalho, Frederico Bruzzi, Maia, Marcelo de Oliveira, Giannini, Fabio Poianas, Machado, Flavia Ribeiro, Dal-Pizzol, Felipe, de Carvalho, Alexandre Guilherme Ribeiro, dos Santos, Ronaldo Batista, Tierno, Paulo Fernando Guimarães Morando Marzocchi, Soares, Marcio, Salluh, Jorge Ibrain Figueira
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.07.2014; BioMed Central
• Subjects: Acute respiratory distress syndrome; Adult; Aged; Cohort Studies; Comorbidity; Complications and side effects; Deep Sedation - methods; Deep Sedation - mortality; Deep Sedation - trends; Development and progression; Female; Hospital Mortality - trends; Hospital patients; Humans; Intensive Care Units - trends; Male; Middle Aged; Patient outcomes; Prospective Studies; Respiration, Artificial - mortality; Respiration, Artificial - trends; Risk factors; Time Factors; Treatment Outcome; Brazil; United Kingdom

Sedation overuse is frequent and possibly associated with poor outcomes in the intensive care unit (ICU) patients. However, the association of early oversedation with clinical outcomes has not been thoroughly evaluated. The aim of this study was to assess the association of early sedation strategies...